Development of thermo/pH-responsive chitosan coated pectin-graft-poly(N,N-diethyl acrylamide) microcarriers

Işıklan, Nuran; Tokmak, Şeyma

doi:10.1016/j.carbpol.2019.04.068

Cited by 40 publications

(11 citation statements)

References 34 publications

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“…Specifically Voo et al have shown complete in vitro dissolution of 2% and 6% w/v alginate beads in 0.1 M phosphate-buffer solution (pH 7.4) at 37 • C after 80 and 240 min, respectively (162). Thermoand pH responsive degradable beads have also been developed in the context of drug delivery (163,164). Steinhilber et al have developed pH-degradable beads, composed of polyglycerol and PEG, which are stable for 2 weeks at 37 • C, pH 7.4 and 5% CO 2 and can be easily degraded in the course of 3 days by lowering the pH to 6.0 while releasing encapsulated NIH3T3 cells with high viability (165).…”

Section: Scenario 2: Non-edible Degradable Microcarriersmentioning

confidence: 99%

Microcarriers for Upscaling Cultured Meat Production

2020

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Section: Scenario 2: Non-edible Degradable Microcarriersmentioning

confidence: 99%

Microcarriers for Upscaling Cultured Meat Production

2020

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“…In the spectrum, C−N stretching at 1379 cm −1 and C−O stretching vibrations at 1072 cm −1 were observed [1b] . On the other hand, it was noted that the characteristic bands of CS and NaCMC in Figure 2 overlapped in the spectrum of the CS coated empty bead carrier and slightly shifted due to cross‐linking and complexation reactions [17] …”

Section: Resultsmentioning

confidence: 95%

“…[1b] On the other hand, it was noted that the characteristic bands of CS and NaCMC in Figure 2 overlapped in the spectrum of the CS coated empty bead carrier and slightly shifted due to crosslinking and complexation reactions. [17] To investigate the presence of AMX in CS-coated AMXloaded bead carriers, the spectra of AMX, CS-coated empty bead carriers, and CS-coated AMX-loaded bead carriers were compared (Figure 3). The most important characteristic peaks in the FTIR spectrum of AMX are listed as follows: CN band NH stretching combination band at 1485 cm À 1 , the C=C stretching (benzene ring) at 1520 cm À 1 , the C=O stretching (amide I) at 1680 cm À 1 , the C=O stretching (β-lactam ring) at 1770 cm À 1 , the amide NH and OH stretching (phenol) at 3440 cm À 1 , and CH stretching (benzene ring) at 3020 cm À 1 .…”

Section: Ftir Analysismentioning

confidence: 99%

Design and Optimization of pH‐Responsive Chitosan‐Coated Zn‐Carboxymethyl Cellulose Hydrogel Bead Carriers for Amoxicillin Trihydrate Delivery

Bulut

2022

ChemistrySelect

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In the study, chitosan (CS)‐coated carboxymethyl cellulose (CMC) bead carriers were developed via electrostatic interactions in the presence of chitosan and zinc ions, using amoxicillin trihydrate (AMX) as a model drug. The beads were produced by cross‐linking with Zn2+ ions by varying the drug/polymer ratio, concentration of chitosan and cross‐linker. Their structures were characterized with FTIR, XRD, TGA, DSC, and SEM. AMX release was investigated at two different pH mediums (1.2 and 7.4) at 37 °C. The release profiles of the carriers were highly affected by the degree of cross‐linking, the AMX/polymer ratio, pH, and especially the chitosan coating. As a result, the optimum AMX release was found as 77.4 % for chitosan‐coated beads (A3) with an AMX/polymer ratio of 1/5, ZnCl2 concentration of 1 %, CS concentration of 1 %. The entrapment efficiency for these carriers (A3) was found to be 57.61 % with high efficiency. It was also determined that AMX release was Fick diffusion and anomalous transport mechanism.

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“…The effect of the use of various origins pectin on the structural and mechanical properties of the obtained polycomposite frameworks has been studied [46]. Various approaches involving the use of scaffolds made of a wide variety of materials, including synthetic and natural polymers, as well as their copolymers, have been experimentally studied to reconstruct skeletal muscle injuries [39,41,[47][48][49][50].…”

Section: Resultsmentioning

confidence: 99%

Features of Polymerization of Methyl Methacrylate using a Photocatalyst—the Complex Oxide RbTe1.5W0.5O6

Семенычева

Chasova

Matkivskaya

et al. 2021

J Inorg Organomet Polym

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Radical polymerization of methylmethacrylate in an aqueous emulsion was carried out using the complex oxide RbTe1.5W0.5O6 as a photoinitiator under visible light irradiation with λ= 400-700 nm. Studies of the process and reaction products using modern methods of physical and chemical analysis (GPC, IR, NMR, etc.) have shown that several directions of monomer transformations occur simultaneously in the reaction mixture. Polymethylmethacrylate, produced in the organic phase and characterized by Mn ~ 140-145 kDa, is a result of polymerization initiation by a hydroxyl radical formed due to complex transformations of electron-hole pairs during irradiation of the photocatalyst. Moreover, the interaction of the hydroxyl radical with OH groups on the complex oxide RbTe1.5W0.5O6 surface and the subsequent formation of oxygen-centered radicals lead to grafting polymer macromolecules onto the photocatalyst surface. In addition, methylmethacrylate is able to oxidize to a cyclic dimer with terminal double bonds and then form a polymer with cyclic dimer links due to coordination by double bonds on the complex oxide RbTe1.5W0.5O6 surface. The high activity of the hydroxyl radical made it possible to obtain the graft copolymer PMMA-pectin by grafting the polymer product onto the surface of the natural polymer-pectin. Comparison of the sponge morphology of the graft copolymer PMMA-pectin and the initial pectin samples using the scanning electron microscopy method showed a noticeable difference in their structural and topological organization. This fact is especially interesting in terms of studying the properties of the graft copolymer as a material for the scaffolds.

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Development of thermo/pH-responsive chitosan coated pectin-graft-poly(N,N-diethyl acrylamide) microcarriers

Cited by 40 publications

References 34 publications

Microcarriers for Upscaling Cultured Meat Production

Microcarriers for Upscaling Cultured Meat Production

Design and Optimization of pH‐Responsive Chitosan‐Coated Zn‐Carboxymethyl Cellulose Hydrogel Bead Carriers for Amoxicillin Trihydrate Delivery

Features of Polymerization of Methyl Methacrylate using a Photocatalyst—the Complex Oxide RbTe1.5W0.5O6

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