Development of the ventriculoarterial segment of the human embryonic heart: A morphometrics study

Thurkow, Erik W.; Wenink, Arnold C. G.

doi:10.1002/ar.1092360410

Cited by 7 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From that time onwards the formation of valves at the atrio-ventricular and ventriculo-arterial junctions becomes more important in avoiding backward flow of the blood when the pressures in both ventricles start to increase (Van Mierop and Bertuch, 1967;Clark et al, 1986). In the human embryo, the atrioventricular cushion tissue has been reported to grow only for a limited period (Mandarim-de-Lacerda, 1991;Wenink, 1992), whereas the distal outlet segment may become thicker, but without changing its length (Thurkow and Wenink, 1993). All these data point at a diminishing role of the atrio-ventricular canal and the distal outlet segment as temporary sphincters.…”

Section: Atrio-ventricular Canal and Distal Outlet Segmentmentioning

confidence: 99%

Growth of the myocardial volumes of the individual cardiac segments in the rat embryo

1995

View full text Add to dashboard Cite

The timing of the septal volume increase fits with qualitative descriptions of ventricular septation. The atrio-ventricular canal and distal outlet segment have an important constrictive function in early stages, when valves are not yet present. Slow conduction and contraction patterns have been reported to be a characteristic feature of these portions of the embryonic heart. With development of valves these segments are loosing their mechanical function and, thus, their proportional volume declines.

show abstract

Section: Atrio-ventricular Canal and Distal Outlet Segmentmentioning

confidence: 99%

Growth of the myocardial volumes of the individual cardiac segments in the rat embryo

1995

View full text Add to dashboard Cite

show abstract

“…The intersegmental junctions, which contain endocardia1 cushion tissue, are described to have a sphincterlike function before valves have developed (Goerttler, 1955;Jaffee, 1965). The atrio-ventricular cushion tissue grows only for a limited period (Mandarim-de-Lacerda, 1991;Wenink, 1992), whereas the distal outlet segment becomes thicker without changing its length (Thurkow and Wenink, 1993). In a previous report, the growth rates of the individual cardiac segments were studied .…”

mentioning

confidence: 99%

Nuclear and cellular size of myocytes in different segments of the developing rat heart

1996

View full text Add to dashboard Cite

Background In the embryonic heart, the individual cardiac segments show different growth rates. For the analysis of changing form in relation with changing function, data on number and shape of cardiomyocytes are necessary. Such data will give insight into the process of hypertrophy and/or hyperplasia as they may take place in the myocardium in the embryonic period. Methods We have measured the volumes of the nuclei and myocytes as well as the surface areas of the nuclear envelope and cellular membrane using stereological tools in rat embryos from 11 days postcoitum to 17 days postcoitum. From the data of the cellular volume of the myocytes and the myocardial volume of the individual segments, we have calculated the total number of myocytes during the developmental period. Results It is shown that the sinus venosus, sinu‐atrial junction, and atrium increase their cellular volume during development, whereas the other cardiac segments show no difference in cellular volume. Similarly, the surface area of the cell membrane of the sinus venosus and sinu‐atrial junction had increased during development. The nuclear volume and the surface area of the nuclear envelope did not differ during the period studied. The total number of myocytes showed a conspicuously smaller increase in the atrio‐ventricular canal and distal outlet segment than in the other segments. Conclusions The increase of the cellular volume in the segments sinus venosus and sinu‐atrial junction seems to be due to a late differentiation process. In general, however, the increase of the myocardial volume in the individual cardiac segments is caused by hyperplasia of the cardiomyocytes in these segments and not by hypertrophy. The surface area of cells has a fixed relationship with cell volume, indicating that no important changes take place in the developmental period studied. © 1996 Wiley‐Liss, Inc.

show abstract

“…2,6B), very extensive remodelling might not be necessary in this area. Moreover, the final position of the aorta has been described to be established in rather early stages (Bartelings andGittenberger-de Groot, 1988, 1989) and any significant change of the length of the distal outlet segment, in the sense of "conal absorption" (Goor et al, 1972) was not found in a recent study (Thurkow and Wenink, 1993).…”

Section: Discussionmentioning

confidence: 92%

Development of the inlet portion of the right ventricle in the embryonic rat heart: The basis for tricuspid valve development

Wenink¹,

Wisse²,

Groenendijk³

1994

Anat. Rec.

Self Cite

View full text Add to dashboard Cite

show abstract

Development of the ventriculoarterial segment of the human embryonic heart: A morphometrics study

Cited by 7 publications

References 25 publications

Growth of the myocardial volumes of the individual cardiac segments in the rat embryo

Growth of the myocardial volumes of the individual cardiac segments in the rat embryo

Nuclear and cellular size of myocytes in different segments of the developing rat heart

Development of the inlet portion of the right ventricle in the embryonic rat heart: The basis for tricuspid valve development

Contact Info

Product

Resources

About