Development of the technology for producing water-soluble melanin from waste of vinary production and the study of its physicochemical properties

Aghajanyan, A.E.; Hambardzumyan, A. A.; Minasyan, Ella V.; Tsaturyan, Avetis H.; Paloyan, Ani M.; Avetisyan, Sona; Hovsepyan, A. S.; Saghyan, Ashot S.

doi:10.1007/s00217-021-03894-9

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…At least four peaks were detected with the last one eluting as a broad peak. The date fruit melanin peaks eluted close to the solvent peak, which agrees with previous findings showing that melanin is not retained on C18 reversed phase columns and elute as multi-peaks together with the solvent 27 , 28 . This result indicates a heterogenic character of the date fruit melanin in agreement with findings on melanin from other sources 29 , 30 .…”

Section: Resultssupporting

confidence: 91%

Melanin is a plenteous bioactive phenolic compound in date fruits (Phoenix dactylifera L.)

Alam

Ramachandran

Antony

et al. 2022

Sci Rep

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Date palm fruits (Phoenix dactylifera L.) were found to contain high levels of allomelanin (1.2–5.1%). The melanin is localized in the tanniferous cells between the inner and outer mesocarp tissues of the fruit. The melanin, extracted with 2 M sodium hydroxide, consisted of amorphous graphene-like granular structures of irregular shape and variable size. The date fruit melanin mainly comprises carbon (64.6%) and oxygen (30.6) but no nitrogen, and was thermally stable. It has radical scavenging (63.6–75.1 IC50, µg/mL), antimicrobial (250–1000 µg/mL), hypoglycemic (51.8–58.2%), and angiotensin-converting-enzyme inhibitory (65.8%) effects. The high level of melanin in date fruits highlights the importance of investigating its dietary intake and its impact on nutrition. This study also suggests that date fruit melanin can be a functional ingredient in foods, food packages, pharmaceuticals, and cosmetics.

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Section: Resultssupporting

confidence: 91%

Melanin is a plenteous bioactive phenolic compound in date fruits (Phoenix dactylifera L.)

Alam

Ramachandran

Antony

et al. 2022

Sci Rep

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“…Thus, the technological novelty of our study lies in the fact that, in contrast to existing methods (Makordey et al ., 1994; Fogarty & Tobin, 1996; Zherebin et al ., 1982; Yao et al ., 2012; Aghajanyan et al ., 2021; Montes‐Avila et al ., 2018; Sava et al ., 2001) an affordable and cost‐effective method for obtaining pure melanin from various types of plant materials and chaga mushroom has been developed. It should be noted that the developed method is mild enough to isolate melanin from grape waste, which is important for protecting melanin from hydrolysis, which can lead to decarboxylation of the chemical structure of target molecules (Ito, 1986).…”

Section: Resultsmentioning

confidence: 99%

“…Soluble pigmented melanin isolated from the chestnut shell is characterised by three fractions of different sizes with fairly close chemical and biological properties (Yao et al 2012). Dark brown melanin has been also isolated as four fraction complexes with a total yield of 17.3% from grape skins (Aghajanyan et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…It was shown that melanin isolated from wine waste had an antibacterial activity against conditionally pathogenic Gram-negative and Gram-positive bacteria, belonging to different taxonomic groups (Minasyan et al, 2023). Water-soluble melanins from plant materials such as tea leaves, chestnut shells, fruit pulp of Vitex mollis and Randia echinocarpa, Auricularia polytricha, sunflower seeds and grape skins exhibit antioxidant activity (Zherebin et al, 1982;Sava et al, 2001;Li et al, 2018;Liu et al, 2019;Wang & Rhim, 2019;Aghajanyan et al, 2021). This ability of melanin has attracted great attention in the development of products for various purposes, including culinary, perfumery, cosmetics, tobacco and pharmaceuticals, as well as solar energy conversion (Davidenko & Gudelow, 2005;Cao et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…2012). Dark brown melanin has been also isolated as four fraction complexes with a total yield of 17.3% from grape skins (Aghajanyan et al ., 2021).…”

Section: Introductionmentioning

confidence: 99%

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Efficient isolation and characterization of functional melanin from various plant sources

Aghajanyan,

Hambardzumyan,

Minasyan

et al. 2024

Int J of Food Sci Tech

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SummaryIn recent years, natural pigments in living organisms have attracted increased interest as an excellent biological material for the development of new biotechnological approaches. Melanin, a large polymeric pigment, has important functions in cells, including free radical scavenging and radiation protection, making this molecule attractive for medical and nutritional purposes. The variety of forms of melanin in organisms requires the use of various approaches to its purification. In this study, we have developed a simple yet unique and effective method for extracting melanin from six plant sources. The melanin yield was in the range of 6.7–21.5% for the plant sources used. The advantage of using grape skin waste as a raw material is shown, which is of great importance for obtaining cheap and functional melanin. The activity of purified melanin in scavenging 2, 2‐diphenyl‐1‐picrylhydrazyl radical is IC50 3.2–99.0 mg L−1. This remarkable feature highlights the attractiveness of grape melanin for further use as a natural antioxidant in medicine. The ability of grape melanin to adsorb heavy metal ions highlights its attractiveness for the food industry and for the development of other biotechnological applications. Smoke, after passing through a cigarette filter charged with melanin, is significantly enriched with reducing agents, which is a phenomenon for the health of smokers.

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Antimicrobial Activity of Melanin Isolated from Wine Waste

Minasyan,

Aghajanyan,

Karapetyan

et al. 2023

Indian J Microbiol

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Development of the technology for producing water-soluble melanin from waste of vinary production and the study of its physicochemical properties

Cited by 5 publications

References 21 publications

Melanin is a plenteous bioactive phenolic compound in date fruits (Phoenix dactylifera L.)

Melanin is a plenteous bioactive phenolic compound in date fruits (Phoenix dactylifera L.)

Efficient isolation and characterization of functional melanin from various plant sources

Antimicrobial Activity of Melanin Isolated from Wine Waste

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