Development of the synthesis of the diamine complexes of covalent conjugates of platinum(II) with octacarboxy-substituted cobalt phthalocyanine

Abstract

Ethylenediamine-N,N′-diacetic acid complexes of the covalent conjugates of octacarboxy-substituted cobalt phthalocyanine with one, two and three platinum atoms (3a–c) were synthesized and characterized by elemental analysis, electronic absorption, infrared and mass spectra data.

Covalent Conjugates of Ammine and Diamine Platinum(II) with Zinc(II) Octacarboxyphthalocyanine

“…Spectra of compounds 2a-d (Figure 1) closely resemble the IR spectra of EDDA containing CCs of platinum(II) and octacarboxysubstituted PcCo II which have been reported previously [5] . It is known that the IR spectra of the compounds containing chelate rings with the metal atoms involved demonstrate two bands in the 1500-1560 cm -1 region [13] .…”

“…[4] Complexes with two and three ammine platinum fragments have been synthesized for the first time. New EDDA containing complexes of CCs of Pt II and octacarboxy-substituted PcZn 2a-d were synthesized using three-stage method analogous to [5] (Scheme 1). The number of platinum atoms in each case was controlled by the stoichiometry of starting materials and was confirmed by elemental analysis data.…”

“…[4] Synthesis of ethylenediamine-N,N′-diacetic acid complexes of the covalent conjugates of octacarboxy-substituted cobalt phthalocyanine with one, two and three platinum atoms was carried out in our laboratory. [5] Investigations of photophysical properties or medical tests were not reported for these compounds, however.…”

Targeted Cancer Phototherapy Using Phthalocyanine–Anticancer Drug Conjugates

“…[44] The solubility of the conjugate was attempted to be improved through using a modified amine ligand in place of the aqua-ligands but the compound was still insoluble and could not be biologically tested. [45] No emission data was recorded meaning it was difficult to determine if the radiative decay pathway had been quenched and how effective the compound would be as a photothermal agent.…”

Synthetic approaches to asymmetric phthalocyanines and their analogues

“…Kalya and co-workers have shown that analogues with partial platinum ions coordination to octacarboxyphthalocyanines lead to formation of asymmetric platinum-containing derivatives 97 potentially useful in combinational cancer therapy ( Figure 6). 276 …”