Development of the rabbit retina. V. The question of ‘columnar units’

Reichenbach, Andreas; Ziegert, M; Schnitzer, Jutta; Pritz-Hohmeier, S; Schaaf, P; Schober, W; Schneider, Hartmut

doi:10.1016/0165-3806(94)90050-7

Cited by 54 publications

(34 citation statements)

References 50 publications

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“…The cone, horizontal, amacrine, and ganglion cells account for only a small proportion (roughly 15%) of the total complement of retinal cells (3,8,11). The majority of the descendants of a single progenitor cell disperse only radially and form clear columns, a migratory pattern that may prove ubiquitous in the vertebrate central nervous system (7).…”

Section: Discussionmentioning

confidence: 99%

“…A variety of lineage-tracing studies report that such clones of cells are aligned in the radial axis, but it is not clear to what extent cells from adjacent clones can intermingle. One study using chimeric mice reports that the descendants of retinal progenitors are aligned in the radial axis (6), suggesting that the mature retina is composed of functional columnar units of cells that are clonally derived (7,8). According to this view, clonal boundaries are rarely transgressed.…”

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confidence: 99%

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Radial and tangential dispersion patterns in the mouse retina are cell-class specific.

Reese

Harvey

Tan

1995

Proc. Natl. Acad. Sci. U.S.A.

114

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The retina is derived from a pseudostratified germinal zone in which the relative position of a progenitor cell is believed to determine the position ofthe progeny aligned in the radial axis. Such a developmental mechanism would ensure that radial arrays of cells which comprise functional units in the mature central nervous system are also clonally related. The present study has tested this hypothesis by using X chromosome-inactivation transgenic mosaic mice. We report that the retina shows a conspicuous distinction for clonally related neuroblasts of different laminar and functional fates: the rod photoreceptor, Muller, and bipolar cells are aligned in the radial axis, whereas the cone photoreceptor, horizontal, amacrine, and ganglion cells are tangentially displaced with respect to them. These results indicate that the dispersion of cell classes across the retinal surface is differ-

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Radial and tangential dispersion patterns in the mouse retina are cell-class specific.

Reese

Harvey

Tan

1995

Proc. Natl. Acad. Sci. U.S.A.

114

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“…In chimeras comprising a mixture of wild-type and mutant cells, only the mutant cells show the mutant phenotypic effect if the gene acts cell autonomously (e.g. they may be Reichenbach et al, (1994), reproduced from Reese and Tan (1998) …”

Section: Chimeric Analysis Of Genetic Control Of Eye Developmentmentioning

confidence: 99%

Analysis of mouse eye development with chimeras and mosaics

Collinson

Hill²,

West³

2004

Int. J. Dev. Biol.

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Analysis of experimental mouse chimeras (chimaeras) and mosaics provides a means of investigating patterning and differentiation within the developing mammalian eye. Chimeric and mosaic mice carry two or more genetically distinct cell populations and extend the repertoire of analytical tools available to the geneticist. Here we review the impact these techniques have had on our understanding of eye organogenesis. Chimeras and mosaics are routinely used to investigate cell lineages, patterns of growth and gene function, and provide a means to clear analytical hurdles that otherwise limit standard genetic approaches. In particular, chimeras are used to investigate the roles of genes in tissues that do not develop in conventional mutant or knock-out mice, to test whether genes act cell autonomously or non-autonomously in different tissues and to dissect tissue-tissue interactions in less tractable, complex systems. Chimeras, in which cells of different genetic composition are mixed at a fine-scale cellular level, may provide qualitatively different data from mosaic mice with conditional knockouts. The uses of chimeras, Cre-loxP mosaics and in vitro tissue recombination for study of ocular organogenesis are compared. Wider use of mosaics and chimeras should provide further insights into eye development.

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“…The close relationship of these neurites with Müller cell fimbriae and mitochondria at regular intervals along the border suggests that neuron sprouting might be guided by these cells. This is comparable to normal retinal neuron development in which Müller cells are known to play an essential role [29, 32, 55]. …”

Section: Discussionmentioning

confidence: 72%

Full-Thickness Retinal Transplants: A Review

Ghosh

Ehinger²

2000

Ophthalmologica

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Embryonic full-thickness rabbit neuroretinal sheets were transplanted to the subretinal space of adult hosts. This was accomplished by using a new transplantation technique involving vitrectomy and retinotomy. The grafts were followed from 10 to 306 days after surgery and were then examined by different histological techniques. In the light microscope, the transplants were seen to develop the normal retinal lamination and fusion with the host retina, especially after long survival times. Ultrastructurally, normal photoreceptor outer segments, well integrated with the host retinal pigment epithelium, were found. Growth cones were present in the zone of fusion between graft and host retina. Immunohistochemical labeling revealed many of the normal retinal components not previously found in retinal transplants, and graft-host connections between neurons in the rod pathway were seen. The morphology of vibratome-sectioned neuroretinal sheets as well as adult full-thickness grafts was also examined. These transplantation types showed less of the normal morphology compared with embryonic full-thickness grafts. The immunogenicity of embryonic full-thickness and fragmented grafts was compared using major histocompatibility complex immunolabeling. Fragmented grafts elicited a response from the host immune system similar to a chronic transplant rejection. This reaction was absent in the full-thickness grafts which is in accordance with their good long-term survival.

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Development of the rabbit retina. V. The question of ‘columnar units’

Cited by 54 publications

References 50 publications

Radial and tangential dispersion patterns in the mouse retina are cell-class specific.

Radial and tangential dispersion patterns in the mouse retina are cell-class specific.

Analysis of mouse eye development with chimeras and mosaics

Full-Thickness Retinal Transplants: A Review

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