Development of the Pulmonary Vein

Moorman, Antoon F.M.; Anderson, Robert H.

doi:10.1002/ar.20572

Cited by 5 publications

(4 citation statements)

References 15 publications

(28 reference statements)

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“…Despite this obvious clinical relevance, the long-established morphological examination of the development of the inflow has yet to produce consensus, as illustrated by the ongoing discussion regarding the relation between development of the pulmonary vein and the systemic venous tributaries [12] , [13] . The reasons for such ongoing disputes lie in part in the lack of use of molecular markers to distinguish between cell types [14] , but also reflect the difficulty of communicating complex three-dimensional processes. Together, these ongoing problems prevent the emergence of a clear morphological concept of development of the venous inflows that could serve as a scaffold for further study.…”

Section: Introductionmentioning

confidence: 99%

Development of the Pulmonary Vein and the Systemic Venous Sinus: An Interactive 3D Overview

Berg

Moorman

2011

PLoS ONE

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Knowledge of the normal formation of the heart is crucial for the understanding of cardiac pathologies and congenital malformations. The understanding of early cardiac development, however, is complicated because it is inseparably associated with other developmental processes such as embryonic folding, formation of the coelomic cavity, and vascular development. Because of this, it is necessary to integrate morphological and experimental analyses. Morphological insights, however, are limited by the difficulty in communication of complex 3D-processes. Most controversies, in consequence, result from differences in interpretation, rather than observation. An example of such a continuing debate is the development of the pulmonary vein and the systemic venous sinus, or “sinus venosus”. To facilitate understanding, we present a 3D study of the developing venous pole in the chicken embryo, showing our results in a novel interactive fashion, which permits the reader to form an independent opinion. We clarify how the pulmonary vein separates from a greater vascular plexus within the splanchnic mesoderm. The systemic venous sinus, in contrast, develops at the junction between the splanchnic and somatic mesoderm. We discuss our model with respect to normal formation of the heart, congenital cardiac malformations, and the phylogeny of the venous tributaries.

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Section: Introductionmentioning

confidence: 99%

Development of the Pulmonary Vein and the Systemic Venous Sinus: An Interactive 3D Overview

Berg

Moorman

2011

PLoS ONE

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“…We only partly agree with the first sentence of the Letter to the Editor by Moorman and Anderson [2]. Disputation alone is not sufficient for progress in science and may even be harmful if combined with dogmatism, as is shown dramatically throughout the history of science.…”

mentioning

confidence: 65%

“…Moreover, we disagree with the alleged arguments for lack of balance in our Review [1], which in our opinion provides a careful balance of citations and opinions that are involved in the current controversy, whereas their criticism does not give full credit to the findings of our group. Here [2] and elsewhere [3][4][5] they either only antagonize our work based on misinterpretations of our concepts, or do not cite it at all. We attempt to cite objectively original basic scientific results but provide our own interpretation of those data without neglecting other views.…”

mentioning

confidence: 84%

“…Obesity and its related health risks including diabetes and coronary artery disease are remarkably increasing in middle income countries experiencing nutrition transition [1]. The prevalence of obesity and its related co-morbidities is rapidly increasing in Iran [2,3], especially among women [4] and adolescents [5]. While obesity is the cornerstone of metabolic syndrome [6] there is less information on management of obesity in these patients.…”

mentioning

confidence: 99%

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