2001
DOI: 10.1016/s0168-3659(01)00341-8
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Development of the polymer micelle carrier system for doxorubicin

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Cited by 531 publications
(358 citation statements)
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“…The hydrophobic inner core enables NK911 to entrap a sufficient amount of DXR. NK911 has a diameter of about 40 nm (Nakanishi et al, 2001). …”
Section: Methodsmentioning
confidence: 99%
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“…The hydrophobic inner core enables NK911 to entrap a sufficient amount of DXR. NK911 has a diameter of about 40 nm (Nakanishi et al, 2001). …”
Section: Methodsmentioning
confidence: 99%
“…The DXR dimers, on the other hand, were thought to stabilise the drug's conformation. Thus, NK911, which only contains DXR monomers, is less stable in aqueous media than the original form of micellar DXR (Nakanishi et al, 2001;Tsukioka et al, 2002).…”
mentioning
confidence: 98%
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“…Recently pharmaceutical applications of polymeric micelles [1][2][3] designed to enable spatial site-specific drug delivery [4] have burst onto a scene with challenging innovations. In tumor treatment the micelles system has proven effective in regression of tumor size while minimizing damage to the healthy tissues [4] and is being actively investigated in conjunction with hyperthermia [5], ultrasound [6], specific enzyme-induced cleavable bonds [7][8][9], and specific ligands or antibodies [10][11][12][13] for active targeting purposes.…”
Section: Introductionmentioning
confidence: 99%