Development of the olivocerebellar projection in the rat: I. Transient biochemical compartmentation of the inferior olive

Wassef, Marion; Chédotal, Alain; Cholley, Béatrice; Thomasset, M.; Heizmann, Claus W.; Sotelo, Constantino

doi:10.1002/cne.903230405

Cited by 83 publications

(69 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of PV immunoreactivity in neurons of the IO in any species is also consistent with previous results from rats (Celio, 1990;Wassef et al, 1992;Paxinos et al, 1999).…”

Section: Comparison Of Neurochemical Properties With Other Speciessupporting

confidence: 92%

“…Expression of CB in IO has been reported for rats and humans; we also saw CB in the IO of cats and macaque monkeys (Celio, 1990;Rogers and Résibois, 1992;Wassef et al, 1992;Paxinos et al, 1999;Nag and Wadhwa, 2004). The absence of PV immunoreactivity in neurons of the IO in any species is also consistent with previous results from rats (Celio, 1990;Wassef et al, 1992;Paxinos et al, 1999).…”

Section: Comparison Of Neurochemical Properties With Other Speciessupporting

confidence: 91%

See 1 more Smart Citation

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Baizer

Sherwood

Hof

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

The inferior olive (IO) is the sole source of the climbing fibers that innervate the Purkinje cells of the cerebellar cortex. The IO comprises several subdivisions, the dorsal accessory olive (DAO), medial accessory olive (MAO), and principal nuclei of the IO (IOpr); the relative sizes of these subnuclei vary among species. In human, there is an expansion of the cerebellar hemispheres and a corresponding expansion of the IOpr. We have examined the structural and neurochemical organization of the human IOpr, using sections stained with cresyl violet (CV) or immunostained for the calcium-binding proteins calbindin (CB), calretinin (CR), and parvalbumin (PV), the synthetic enzyme for nitric oxide (nNOS), and nonphosphorylated neurofilament protein (NPNFP). We found qualitative differences in the folding patterns of the IOpr among individuals and between the two sides of the brainstem. Quantification of IOpr volumes and indices of folding complexity, however, did not reveal consistent left-right differences in either parameter. Single-label immunohistochemistry showed that populations of neurons in the IOpr express CB, CR, NPNFP, and nNOS. Individual fibers labeled for PV, CB, CR, NPNFP, and nNOS were also found. There was individual variability in the numbers and density of stained neurons in the human IOpr; such variability was not seen in other brainstem nuclei. These data are consistent with, and complement, earlier studies showing a dramatic age-related increase in lipofuscin and decrease in RNA in the human IOpr. The impact of these changes in the IOpr on cerebellar function is, however, not known. Anat Rec, 294:1198Rec, 294: -1216Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

show abstract

“…The absence of PV immunoreactivity in neurons of the IO in any species is also consistent with previous results from rats (Celio, 1990;Wassef et al, 1992;Paxinos et al, 1999).…”

Section: Comparison Of Neurochemical Properties With Other Speciessupporting

confidence: 92%

Section: Comparison Of Neurochemical Properties With Other Speciessupporting

confidence: 91%

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Baizer

Sherwood

Hof

et al. 2011

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…10). The leading process of IO neurons transforms into an axon that approaches the cerebellum as the cell body reaches to the floor plate (Wassef et al, 1992). The floor plate was then proposed to attract ventrally migrating precerebellar neurons (Bourrat and Sotelo, 1990b), a process later shown to involve DCC/netrin-1 (Bloch-Gallego et al, 1999;Yee et al, 1999;Causeret et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…DAO neurons are born first and are also the ones that are the most affected in Slit/Robo mutants. Before IO subdivisions adopt their final morphology, they already express different combination of proteins (Wassef et al, 1992), including axon guidance molecules and receptors (Chedotal et al, 1996;Nishida et al, 2002;Backer et al, 2007). Interestingly, mice lacking the Rho-GEF (guanine exchange factor) Trio exhibit IO lamellation defects resembling those observed in Robo1/Robo2 and Slit1/Slit2 mutants (Backer et al, 2007).…”

Section: Slit/robo Signaling and Io Lamellationmentioning

confidence: 99%

Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Meglio¹,

Nguyen-Ba-Charvet²,

Tessier‐Lavigne³

et al. 2008

Journal of Neuroscience

View full text Add to dashboard Cite

Precerebellar neurons of the inferior olive (IO) and lateral reticular nucleus (LRN) migrate tangentially from the rhombic lip toward the floor plate following parallel pathways. This process is thought to involve netrin-1 attraction. However, whereas the cell bodies of LRN neurons cross the midline, IO neurons are unable to do so. In many systems and species, axon guidance and cell migration at the midline are controlled by Slits and their receptor Robos. We showed previously that precerebellar axons and neurons do not cross the midline in the absence of the Robo3 receptor. To determine whether this signaling by Slits and the two other Robo receptors, Robo1 and Robo2, also regulates precerebellar neuron behavior at the floor plate, we studied the phenotype of Slit1/2 and Robo1/2/3 compound mutants. Our results showed that many IO neurons can cross the midline in absence of Slit1/2 or Robo1/2, supporting a role for midline repellents in guiding precerebellar neurons. We also show that these molecules control the development of the lamellation of the inferior olivary complex. Last, the analysis of Robo1/2/3 triple mutants suggests that Robo3 inhibits Robo1/2 repulsion in precrossing LRN axons but not in IO axons in which it has a dominant and distinct function.

show abstract

“…In this mutation, the Purkinje cell is believed to be directly affected by the abnormal staggerer gene, suggesting that Purkinje cells play a role in the organization of this mossy fiber system. 3) Purkinje cells and olivary cells express biochemical heterogeneities during embryonic development (Wassef and Sotelo, 1984;Wassef et al, 1985Wassef et al, , 1992. These have been suggested to play a role in the matching of olivocerebellar and other fibers to these heterogeneous parasagittally arranged groups of Purkinje cells.…”

Section: Purkinje Cells As Organizersmentioning

confidence: 99%

Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Paradies

Eisenman

1993

Developmental Dynamics

View full text Add to dashboard Cite

Many projection systems within the peripheral and central nervous system are topographically organized, and it has become increasinging clear that interactions which occur during development determine the projection patterns these systems exhibit in the adult. The olivocerebellar system was chosen as a model system for this study of afferent pattern formation because it has several characteristics which lend themselves to a study of this type. Applications of horseradish peroxidase were made to both the cerebellar primordium and to the inferior olive of embryonic and neonatal mice using an in vitro perfusion system to support the tissue during the transport period. Fibers labeled after restricted olivary applications are limited to particular mediolateral regions of the cerebellum. Similarly, olivary cells retrogradely labeled after discrete cerebellar applications are restricted to particular olivary subdivisions. The results indicate that the olivocerebellar projection displays elements of topographic organization as early as El5 and that the pattern displayed is roughly comparable to that of the adult mammal. The observed trajectories of olivocerebellar fibers and their concomitant association with both Purkinje and cerebellar nuclear cells during embryonic development suggests a role for either or both cell types in the pattern formation process. 0 1993 Wiley-Liss, Inc.

show abstract

Development of the olivocerebellar projection in the rat: I. Transient biochemical compartmentation of the inferior olive

Cited by 83 publications

References 41 publications

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Neurochemical and Structural Organization of the Principal Nucleus of the Inferior Olive in the Human

Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Evidence of early topographic organization in the embryonic olivocerebellar projection: A model system for the study of pattern formation processes in the central nervous system

Contact Info

Product

Resources

About