Development of the NADPH-diaphorase-positive neurons in the sympathetic ganglia

Emanuilov, A. I.; Korzina, M. B.; Арчакова, Л. И.; Novakovskaya, S. A.; Nozdrachev, A. D.; Maslyukov, P. M.

doi:10.1016/j.aanat.2008.05.005

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…Previous data by our group have revealed that the changes in the number of NADPH‐d‐positive cells during development occur differently in the various sympathetic ganglia, which is now further substantiated by our current results about the development of nNOS‐IR neurons. The proportion of NADPH‐d‐positive and nNOS‐IR cells in the SG increased in first 20 days of life, whereas those in the CG and SCG did not change in number during development (Masliukov et al, 2003; Emanuilov et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…In cats, we previously found some changes in the number of sympathetic neurons expressing NADPH‐d. In the SG, the proportion of NADPH‐d‐positive cells increased in the first 20 days and then decreased again between the first and the second month of life (Emanuilov et al, 2008). NADPH‐d histochemistry is often used to label nNOS‐containing neurons in the nervous system (Hope et al, 1991; Santer and Symons, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Taking together, the purpose of this study was to gain further insight into the neuroplasticity of sympathetic neurons during early postnatal ontogenesis by comparing the development of non‐catecholaminergic neurons expressing different markers in para‐ and prevertebral sympathetic ganglia. In the current work, we performed our experiments on cats since NOS‐IR neurons are absent in rodents (Emanuilov et al, 2008; Masliukov et al, 2014) and because the highest numbers of nitrergic neurons are observed in the cat and human sympathetic ganglia (Klimaschewski et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Development of non‐catecholaminergic sympathetic neurons in para‐ and prevertebral ganglia of cats

Maslyukov

Emanuilov

Moiseev

et al. 2014

Intl J of Devlp Neuroscience

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Expression of vasoactive intestinal peptide (VIP), neuronal nitric oxide synthase (nNOS), choline acetyltransferase (ChAT) and calcitonin gene-related peptide (CGRP) in the sympathetic ganglia was investigated by immunohistochemistry in the superior cervical ganglion (SCG), stellate ganglion (SG) and celiac ganglion (CG) from cats of different ages (newborn, 10-day-old, 20-day-old, 30-day-old and 2-month-old). Non-catecholaminergic TH-negative VIP-immunoreactive (IR) and nNOS-IR sympathetic ganglionic neurons are present from the moment of birth. In all studied age groups, substantial populations of VIP-IR (up to 9.8%) and nNOS-IR cells (up to 8.3%) was found in the SG, with a much smaller population found in the SCG (<1%) and only few cells observed in the CG. The percentage of nNOS-IR and VIP-IR neurons in the CG and SCG did not significantly change during development. The proportion of nNOS-IR and VIP-IR neuron profiles in the SG increased in first 20 days of life from 2.3±0.15% to 8.3±0.56% and from 0.3±0.05% to 9.2±0.83%, respectively. In the SG, percentages of nNOS-IR sympathetic neurons colocalizing VIP increased in the first 20 days of life. ChAT-IR and CGRP-IR neurons were not observed in the sympathetic ganglia of newborn animals and did not appear until 10 days after birth. In the SG of newborn and 10-day-old kittens, the majority of NOS-IR neurons were calbindin (CB)-IR, whereas in the SCG and CG of cats of all age groups and in the SG of 30-day-old and older kittens, the vast majority of NOS-IR neurons lacked CB. We conclude that the development of various non-catecholaminergic neurons in different sympathetic ganglia has its own time dynamics and is concluded at the end of the second month of life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of non‐catecholaminergic sympathetic neurons in para‐ and prevertebral ganglia of cats

Maslyukov

Emanuilov

Moiseev

et al. 2014

Intl J of Devlp Neuroscience

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“…There are different changes in nNOS expression in the autonomic neurons during postnatal ontogenesis. In the sympathetic nervous system of rodents, nNOS‐IR neurons are absent in para‐ and prevertebral ganglia throughout postnatal development (Emanuilov et al, 2008), but they are present in large numbers in the preganglionic neurons of the spinal cord. In the spinal cord, the percentage of nNOS‐IR preganglionic spinal sympathetic neurons is maximal in newborns but decreases significantly during the first month of life (Moiseev et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Postnatal development of the enteric neurons expressing neuronal nitric oxide synthase

Budnik

Maslyukov

2022

The Anatomical Record

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Neurons, expressing neuronal nitric oxide synthase (nNOS) in the enteric ganglia are inhibitory motor neurons or interneurons. The aim of the study was to identify the percentage, cross‐sectional area of nNOS‐immunoreactive (IR) neurons and their colocalization with choline acetyltransferase (ChAT), vasoactive intestinal polypeptide (VIP), and neuropeptide Y in the intramural ganglia of the myenteric (MP) and submucous plexus (SP) of the small intestine (SI) and large intestine (LI) of rats of different age groups using immunohistochemical methods. In the intramural ganglia of the MP, the largest percentage of nNOS‐IR neurons was detected in newborn rats in the LI (81 ± 0.9%) and SI (48 ± 4.1%). Subsequently, it decreased in ontogenesis up to 60 days of life (26 ± 0.9% LI, 29 ± 3.2% SI), and did not change until senescence. In the SP, abundant nNOS‐IR neurons were also detected in newborns (82 ± 7.0% SI, 85 ± 3.2% LI), while their percentage decreased significantly in the next 20 days. Furthermore, a very small number of nNOS‐IR neurons was detected in 30‐day‐ and 2‐month‐old animals, but they again appeared in large numbers in aged rats. In the MP, the highest percentage of nNOS+/ChAT+ neurons was in 1‐day‐old, 10‐day‐old, and 2‐year‐old rats. In the SP, the largest number of nNOS‐IR neurons colocalized ChAT regardless of age. In the MP of all rats, many nNOS‐IR neurons colocalized VIP, and the maximal percentage of nNOS+/VIP+ neurons was found in 2‐year‐old rats, minimal—in newborns. In conclusion, nNOS expression in neurons of the gut is decreased in early postnatal ontogenesis and subsequently increased in aged rats.

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“…Under the guidance of Georg V. Stovichek et al (1974), the myeloarchitectonics of visceral nerves, and the morphogenesis of the nervous connections of internal organs in ontogenesis were studied. Sensitive and sympathetic innervation of internal organs in postnatal development and under experimental influence was investigated in the works of Valentin V. Shilkin , Valentina V. Porseva (Porseva et al, 2017), Andrey Emanuilov et al (2008), Petr M. Masliukov . Petr Masliukov, a former PhD student of Nozdrachev, carried out a comprehensive study of the patterns of age‐related changes in the innervation of internal organs; he described in detail the morphological, neurochemical and functional characteristics of the neurons of the ANS in postnatal ontogenesis (Masliukov, 2001; Masliukov et al, 2000a, 2000b, 2016).…”

Section: Russian Autonomic Research During the Soviet And Post‐soviet...mentioning

confidence: 99%

A brief history of Russian research on the autonomic nervous system

Nozdrachev

2022

The Anatomical Record

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The first information on the structure and function of the autonomic nervous system dates back to the time of Galen (second century), while the beginning of the study of the autonomic nervous system in Russia can be traced back to the mid‐19th century. This review is devoted to the professional achievements of Russian researchers in the 19th and 20th centuries who were active in the field of the autonomic nervous system at different stages of the development of neuromorphology and neurophysiology. In addition, recent achievements of modern Russian researchers active in this domain are also highlighted. This review is mainly devoted to research on the autonomic nervous system in Russia, but it would be unfair not to mention the scientists who made a significant contribution to this field of science and worked in the republics of the former USSR. Russian morphology and physiology developed under the significant influence of well‐known western scientific schools. I sincerely hope that cooperation between Russian and foreign colleagues will continue and will be fruitful for global science.

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Development of the NADPH-diaphorase-positive neurons in the sympathetic ganglia

Cited by 16 publications

References 31 publications

Development of non‐catecholaminergic sympathetic neurons in para‐ and prevertebral ganglia of cats

Development of non‐catecholaminergic sympathetic neurons in para‐ and prevertebral ganglia of cats

Postnatal development of the enteric neurons expressing neuronal nitric oxide synthase

A brief history of Russian research on the autonomic nervous system

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