Development of the Jackson Heart Study Coordinating Center

Campbell-Jenkins, Brenda W.; Addison, Clifton; Young, Lavon; Anugu, Pramod; Wilson, Gregory; Sarpong, Daniel F.

doi:10.3390/ijerph6051597

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…The JHS is a longitudinal study established in 2000 to characterize the determinants of CVD in 5,301 African Americans ascertained in Jackson, Mississippi33. For the purpose of genetic analysis, consenting family members age 21 or older were ascertained32.…”

Section: Methodsmentioning

confidence: 99%

SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Jeff

Brown-Gentry

Buxbaum

et al. 2011

Circ Cardiovasc Genet

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Background-Understanding variation in the normal electric activity of the heart, assessed by the ECG, may provide a starting point for studies of susceptibility to serious arrhythmias such as sudden cardiac death during myocardial infarction or drug therapy. Recent genetic association studies of one ECG trait, the QT interval, have identified common variation in European-descent populations, but little is known about the genetic determinants of ECG traits in populations of African descent. Methods and Results-To identify genetic risk factors, we have undertaken a candidate gene study of ECG traits in collaboration with the Jackson Heart Study, a longitudinal study of 5301 blacks ascertained from the Jackson, Mississippi, area. Nine quantitative ECG traits were evaluated: P, PR, QRS, QT, and QTc durations, heart rate, and P, QRS, and T axes. We genotyped 72 variations in the predominant sodium channel gene expressed in heart, SCN5A, encoding the Na v 1.5 voltage-gated sodium channel in 4558 subjects. Both rare and common variants in this gene have previously been associated with inherited arrhythmia syndromes and variable conduction. Adjusting for age, sex, and European ancestry, we performed tests of association in 3054 unrelated participants and identified 14 significant associations (PϽ1.0ϫ10 Ϫ4 ), of which 13 are independent, based on linkage disequilibrium. These variants explain up to 2% of the variation in ECG traits in the Jackson Heart Study. Conclusions-These results suggest that SCN5A variation contributes to ECG trait distributions in blacks, and these same variations may be risk or protective factors associated with susceptibility to arrhythmias. (Circ Cardiovasc Genet. 2011; 4:139-144.)Key Words: electrocardiography Ⅲ arrhythmia Ⅲ genetics Ⅲ ion channels Ⅲ cardiovascular diseases M any factors are known to influence ECG measurements, including underlying heart disease such as coronary heart disease or hypertension, drug therapy, body mass index, and age. These factors, however, do not explain the majority of the trait variance observed in ECG traits, and a large portion of the variance remains unknown. 1,2 Studies in twins and populations have reported that Ͼ35% of the variance observed for specific ECG traits is heritable. [3][4][5][6][7][8] Given the heritability of ECG traits, it is possible that common genetic variation in genes that modulate the electric activity of the heart can explain a proportion of the unknown trait variance observed in the general population. Insights into such normal variability may in turn provide the starting point for predicting serious cardiovascular events such as druginduced arrhythmias or sudden cardiac death (SCD). 4 -7 SCD accounts for 10% to 20% of all deaths in adults, and risk factors include underlying heart disease and a family history of SCD. [5][6][7] Clinical Perspective on p 144The opening of sodium channels is responsible for initiating and propagating action potentials in cardiac and other excitable cells. 8 -17 Sodium channels are encoded by 9 poref...

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Section: Methodsmentioning

confidence: 99%

SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Jeff

Brown-Gentry

Buxbaum

et al. 2011

Circ Cardiovasc Genet

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“…The AJA model was developed by infusing experiences and ideas generated over a period of 13 years of community mobilizing/partnership-building that was the focus of the functions of the JHS Community Partnership Office (CPO). During the first contract period of the JHS (2000–2013), the CPO was infused into the operations of the JHS Coordinating Center and became recognized as a major force in the JHS cohort recruitment and retention efforts [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Building Collaborative Health Promotion Partnerships: The Jackson Heart Study

Addison

Jenkins

Odom

et al. 2015

IJERPH

Self Cite

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Building Collaborative Health Promotion Partnerships: The Jackson Heart Study. Background: Building a collaborative health promotion partnership that effectively employs principles of community-based participatory research (CBPR) involves many dimensions. To ensure that changes would be long-lasting, it is imperative that partnerships be configured to include groups of diverse community representatives who can develop a vision for long-term change. This project sought to enumerate processes used by the Jackson Heart Study (JHS) Community Outreach Center (CORC) to create strong, viable partnerships that produce lasting change. Methods: JHS CORC joined with community representatives to initiate programs that evolved into comprehensive strategies for addressing health disparities and the high prevalence of cardiovascular disease (CVD). This collaboration was made possible by first promoting an understanding of the need for combined effort, the desire to interact with other community partners, and the vision to establish an effective governance structure. Results: The partnership between JHS CORC and the community has empowered and inspired community members to provide leadership to other health promotion projects. Conclusion: Academic institutions must reach out to local community groups and together address local health issues that affect the community. When a community understands the need for change to respond to negative health conditions, formalizing this type of collaboration is a step in the right direction.

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“…However, very little exists in the literature describing the creation of DCCs or the guiding principles behind their inception. Furthermore, what has been published is either disease-specific or localized to a particular study, and therefore difficult to generalize [[16], [17], [18], [19]].…”

Section: Introductionmentioning

confidence: 99%

Creating an academic research organization to efficiently design, conduct, coordinate, and analyze clinical trials: The Center for Clinical Trials & Data Coordination

Abebe

Althouse

Comer

et al. 2019

Contemporary Clinical Trials Communications

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When properly executed, the randomized controlled trial is one of the best vehicles for assessing the effectiveness of one or more interventions. However, numerous challenges may emerge in the areas of study startup, recruitment, data quality, cost, and reporting of results. The use of well-run coordinating centers could help prevent these issues, but very little exists in the literature describing their creation or the guiding principles behind their inception.The Center for Clinical Trials & Data Coordination (CCDC) was established in 2015 through institutional funds with the intent of 1) providing relevant expertise in clinical trial design, conduct, coordination, and analysis; 2) advancing the careers of clinical investigators and CCDC-affiliated faculty; and 3) obtaining large data coordinating center (DCC) grants. We describe the organizational structure of the CCDC as well as the homegrown clinical trial management system integrating nine crucial elements: electronic data capture, eligibility and randomization, drug and external data tracking, safety reporting, outcome adjudication, data and safety monitoring, statistical analysis and reporting, data sharing, and regulatory compliance.Lastly, we share numerous lessons that can be taken from our experience. Specifically, we focus on 1) funding for DCCs, 2) the importance of DCCs to clinical researchers, 3) the expertise of DCC personnel, and 4) continually striving to improve.In conclusion, the CCDC strives to provide high-quality support for the design, conduct, coordination, and analyses of clinical trials, and we hope this paper will serve as a blueprint for future clinical trialists involved in DCCs.

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Development of the Jackson Heart Study Coordinating Center

Cited by 10 publications

References 11 publications

SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study

Building Collaborative Health Promotion Partnerships: The Jackson Heart Study

Creating an academic research organization to efficiently design, conduct, coordinate, and analyze clinical trials: The Center for Clinical Trials & Data Coordination

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