Development of the Information System for Tick-Hazard on the Basis of the Objective Ontology

Molorodov, Yu.I.; Khodorchenko, D. A.

doi:10.25205/1818-7900-2018-16-4-107-114

Cited by 3 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, there are two types of monitoring platforms related to TBEV. The first type contains platforms for monitoring disease vectors, including those that transmit vector-borne diseases [ 16 ], e.g., the entomological platform specialized on monitoring ticks called VectorMap (vectormap.si.edu) [ 17 ]. The second type of platform is specialized on TBEV genetic/phylogenetic characteristics, such as the Virus Pathogen Database and Analysis Resource (ViPR) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Identifying New Clusterons: Application of TBEV Analyzer 3.0

et al. 2023

View full text Add to dashboard Cite

Early knowledge about novel emerging viruses and rapid determination of their characteristics are crucial for public health. In this context, development of theoretical approaches to model viral evolution are important. The clusteron approach is a recent bioinformatics tool which analyzes genetic patterns of a specific E protein fragment and provides a hierarchical network structure of the viral population at three levels: subtype, lineage, and clusteron. A clusteron is a group of strains with identical amino acid (E protein fragment) signatures; members are phylogenetically closely related and feature a particular territorial distribution. This paper announces TBEV Analyzer 3.0, an analytical platform for rapidly characterizing tick-borne encephalitis virus (TBEV) strains based on the clusteron approach, workflow optimizations, and simplified parameter settings. Compared with earlier versions of TBEV Analyzer, we provide theoretical and practical enhancements to the platform. Regarding the theoretical aspect, the model of the clusteron structure, which is the core of platform analysis, has been updated by analyzing all suitable TBEV strains available in GenBank, while the practical enhancements aim at improving the platform’s functionality. Here, in addition to expanding the strain sets of prior clusterons, we introduce eleven novel clusterons through our experimental results, predominantly of the European subtype. The obtained results suggest effective application of the proposed platform as an analytical and exploratory tool in TBEV surveillance.

show abstract

Section: Introductionmentioning

confidence: 99%