Development of the human pancreas: variations and pathology. A tentative classification

Adda, Guido; Hannoun, L.; Loygue, J

doi:10.1007/bf01798752

Cited by 72 publications

(70 citation statements)

References 44 publications

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“…Dorsal and ventral pancreas budding is first evident at 26-35 dpc (day post coitum), and fusion of the anlagen occurs at 6 weeks of gestation (G6w, gestation 6 weeks). The dorsal bud produces most of the head, body, and tail of the mature pancreas, whereas the ventral bud contributes to the inferior part of the head of the organ (Adda et al, 1984;Slack, 1995;Polak et al, 2000;Piper et al, 2004).…”

Section: Human Pancreas Development: a Comparison To Mousementioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

514

594

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Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature b-cells. Developmental Dynamics 240:530-565,

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Section: Human Pancreas Development: a Comparison To Mousementioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

514

594

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“…While the dorsal and ventral pancreas buds initially extend in opposite directions, the ventral pancreas bud rotates with the duodenum and settles under the dorsal pancreas bud (1-3, 11, 19). Between the postcoital 26 th and 35 th day, ventral and dorsal pancreas buds exist separately in human beings (40). The unification of these buds occurs between the postcoital 37 th and 42 nd day in human beings (41).…”

Section: Pancreas Developmentmentioning

confidence: 99%

Development of Liver and Pancreas

Eşrefoğlu¹,

Taşlıdere²,

Çetin³

2016

Bezmialem Science

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The parenchyma of the liver and pancreas is derived from the endoderm, whereas the stroma is derived from the mesoderm. Both of them are derived from the endoderm of the foregut as the esophagus, stomach, and a part of duodenum. At the 3 rd -4 th of development, the liver, gallbladder and bile ducts become diverticulum hepaticum that is derived from the caudal portion of the foregut. There were inductive effects of septum transversum and cardiac mesoderm for the development of liver diverticulum. The pancreas arise from the endoderm of the foregut. The pancreas is derived from the fusion of the ventral and dorsal pancreas bulbs, which arise from the endoderm of the duodenum. The inductive effects of the notochord and dorsal aorta play a role in the development of the pancreas. In this manuscript, we attempted to review the morphological and functional development of the liver and pancreas with the aid of pictures obtained from various stages of prenatal and postnatal development in the organs of rats.

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“…The APD is formed by the proximal portion of the main duct of the dorsal primordium, and usually undergoes atrophy and becomes the less constant pancreatic duct [1, 2]. Why does the APD become atrophic?…”

Section: Introductionmentioning

confidence: 99%

Embryology of the Pancreatic Duct System

Kamisawa

Koike²,

Okamoto³

1999

Digestion

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Background/Aims: It has been suggested that the distal portion of the dorsal pancreatic duct and the ventral pancreatic duct usually merge into the main pancreatic duct, and the proximal portion of the dorsal pancreatic duct becomes the accessory pancreatic duct. In this study, we investigated the embryology of the accessory pancreatic duct roentgenographically and immunohistochemically. Methods/Results: The accessory pancreatic duct shows two different patterns in pancreatograms: the long and the short type. The accessory pancreatic duct of the long type forms a straight line and joins the main pancreatic duct at the neck portion of the pancreas. The accessory pancreatic duct of the short type joins the main pancreatic duct near its first inferior branch. Long inferior branches from the accessory pancreatic duct were found in 74.6% with the long type, significantly more often than in the short type (29.3%). Patency of the long type was (74.5%) significantly greater than in the short type (36.2%). Immunohistochemically, we found the main pancreatic duct between the junction with the accessory pancreatic duct and the neck portion of the autopsy pancreas in the short type was located within the ventral pancreas, characterized by pancreatic polypeptide-rich islets. Conclusion: The long type represents a continuation of the main duct of the dorsal primordium. The short type is very likely formed by the proximal main duct of the dorsal primordium and its long inferior branch, with the main duct of the dorsal primordium at the point of connection with the main duct of the ventral primordium being obliterated and replaced by this additional communication.

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Development of the human pancreas: variations and pathology. A tentative classification

Cited by 72 publications

References 44 publications

Pancreas organogenesis: From bud to plexus to gland

Pancreas organogenesis: From bud to plexus to gland

Development of Liver and Pancreas

Embryology of the Pancreatic Duct System

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