Development of the Fetal Lung

Liggins, G. C.; Kitterman, Joseph A.

doi:10.1002/9780470720684.ch15

Cited by 27 publications

(7 citation statements)

References 79 publications

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“…Postnatal survival depends on an adequate level of maturation of key systems such as the lung. In sheep, the prenatal rise in fetal cortisol that occurs in the final twenty days of gestation 2 has been shown to be essential for terminal differentiation of the fetal lung 3. Administration of synthetic glucocorticoids (sGC) to pregnant women threatening premature labor has clearly proven to be beneficial in enhancing survival of offspring by accelerating lung maturation and decreasing the incidence of neonatal morbidity and mortality 4;5.…”

Section: Introductionmentioning

confidence: 99%

Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons

Rodriguez¹,

Zürcher²,

Keenan³

et al. 2011

American Journal of Obstetrics and Gynecology

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Objective-We investigated effects of three weekly courses of fetal betamethasone (βM) exposure on motivation and cognition in juvenile baboon offspring utilizing the Cambridge Neuropsychological Test Automated Battery.Study design-Pregnant baboons (Papio sp.) received two injections of saline control (C) or 175 μg/kg βM 24h apart at 0.6, 0.65 and 0.7 gestation. Offspring [Female (FC), n = 7 and Male (MC), n = 6; Female (FβM), n = 7 and Male (MβM), n = 5] were studied at 2.6-3.2 years with a progressive ratio test for motivation, simple discriminations (SD) and reversals (SR) for associative learning and rule change plasticity, and an intra-dimensional/extra-dimensional (IDED) set-shifting test for attention allocation. Conclusion-This central nervous system developmental programming adds growing concerns of long-term effects of repeated fetal synthetic glucocorticoid exposure. In summary, behavioral effects observed show sex specific differences in resilience to multiple fetal βM exposures. Results-βM

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Section: Introductionmentioning

confidence: 99%

Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons

Rodriguez¹,

Zürcher²,

Keenan³

et al. 2011

American Journal of Obstetrics and Gynecology

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“…Increased pulmonary size is a phenomenon that is explained as parenchymal hyperplasia secondary to retained lung fluids in upper airway obstruction, which has been recognized by Dolkart et al, 11 Morrison et al, 16 and Liggins. 23 In a fetus with enlarged hyperechoic lungs, a differential diagnosis of a type 3 bilateral cystic adenoid malformation should be considered. 3 Laryngeal atresia is associated with other structural and genetic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Isolated Laryngeal Atresia

Güven

Akturk

et al. 2007

Journal of Ultrasound in Medicine

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“…These models point at the substantial importance of the space-occupying effect caused by the intrathoracically herniated abdominal content. Consequently, a secondary and important impact on the lung growth and pulmonary function occurs [13] . Histological findings consist of significantly reduced lung weights and air capacities, decreased number of vessels per unit, decreased cross-sectional area of the pulmonary vascular bed or pulmonary hypertension and decreased pulmonary compliance [14] .…”

Section: Discussionmentioning

confidence: 99%

T2 Quantifications of Lungs in the Fetal Lamb with Experimentally-Induced Congenital Diaphragmatic Hernia

Breysem¹,

Bosmans²,

Jani³

et al. 2006

Fetal Diagn Ther

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Objective: As an aid to evaluate lung hypoplasia, we investigated the difference between T2 value in fetal lungs of lambs with surgically-induced left-sided diaphragmatic hernia (DH) and gestational age (GA)-matched control littermates (normal [NL]). Methods: Lungs were divided into two groups: DH (n = 4) and NL (n = 6). DH was induced at 65–75 days GA (term = 145 days). Fetal MRI was performed (mean GA: 120 days) with half-Fourier acquisition single-shot turbo spin-echo (TE: 60 ms) and rapid acquisition with relaxation enhancement (TE: 350 ms) in the same location (1.5-T Philips, Gyroscan, Best, The Netherlands). T2 of each lung was calculated for multiple regions of interest by taking natural logarithm of signal-to-noise ratio. Mean T2 was compared between DH and NL (unpaired analysis for entire group). Paired comparison between left/right lung was made within DH and NL. Results: Unpaired analysis showed significantly lower T2 of left respectively right lungs in DH (p = 0.02 [respectively] 0.05]) compared to NL (n = 6), as well as between the T2 of all DH versus NL (p = 0.001). In DH, calculated T2 appeared to be lower in left than in right lungs (difference ranged from –2 to +49%). In NL, left and right lungs showed comparable T2. Conclusion: Measurement of T2 signal intensity in DH lungs is feasible and show lower T2 in comparison to NL lungs. Left lungs from lambs with DH show lower T2 than right lungs.

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Development of the Fetal Lung

Cited by 27 publications

References 79 publications

Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons

Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons

Prenatal Diagnosis of Isolated Laryngeal Atresia

T2 Quantifications of Lungs in the Fetal Lamb with Experimentally-Induced Congenital Diaphragmatic Hernia

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