Development of the definition of sepsis

Dimić, Nemanja; Đurić, Marko; Nenadić, Irina; Boboš, Marina; Bojić, Suzana; Vukotić, Tatjana; Simeunović-Gojgić, Mirjana; Gojgić, Milan; Stevanović, Predrag; Bojović, Ksenija

doi:10.5937/smclk4-42608

Cited by 3 publications

(1 citation statement)

References 28 publications

(56 reference statements)

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“…In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock defined sepsis-3 as life-threatening organ dysfunction, acknowledging the severe, lethal threat of a pathogen invading the body [ 3 , 4 ]. The diagnosis of organ dysfunction is now based on Sequential Organ Failure Assessment (SOFA) score changes of at least two points as a result of acute infection [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship

Pătrașcu,

Vâță,

Temelie-Olinici

et al. 2024

Diagnostics

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Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020–2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma. Cultured samples revealed S. aureus, P. aeruginosa, and E. coli; and K. pneumoniae and S. β-hemolytic associated with sepsis, even if this was rarer. Clinical manifestations included ulcerations, erosions, fissures, excoriations, bullae, vesicles, pruritus, tumefaction, edema, fever, chills, pain, adenopathy, and mildly altered mental status. Underlying chronic heart failure, atrial fibrillation, anemia, and type-1 diabetes mellitus were comorbidities associated with infection and sepsis. Significant associations and risk factors, including their combined effects, are discussed to draw attention to the need for further research and adequate management to prevent sepsis in adult patients of any age presenting with infected skin lesions (especially cellulitis) and comorbidities (especially type 1 diabetes mellitus and anemia).

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Section: Introductionmentioning

confidence: 99%

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship

Pătrașcu,

Vâță,

Temelie-Olinici

et al. 2024

Diagnostics

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Fever and sepsis - dangerous controversies

Djurica,

Becejac,

Adamovic

et al. 2022

Med pregl

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Introduction. Sepsis is the body?s response to infection, leading to tissue and organ damage. Although fever was considered to be an important sign of sepsis, it has been shown that half of the critically ill patients with sepsis do not have fever at the time of diagnosis. Absence of high body temperature may be a serious disruption of the thermoregulatory response to infection and therefore a reflection of the disease severity. The aim of this study was to determine the percentage of patients with sepsis without fever, and to compare the clinical presentation and outcome of the disease in febrile and afebrile patients. Material and Methods. A retrospective study included 597 patients with sepsis who were divided into two groups: the first included patients with elevated body temperature (? 37.7 ?) and the second included patients who were afebrile (< 37.7 ?). Demographic data, clinical, laboratory and microbiological data, gas analysis parameters, length of hospitalization, and data on the disease outcome were collected and analyzed for all patients. Results. The results show that 41.9% of patients with sepsis did not have fever in the first 24 hours of hospitalization. In the group of afebrile patients, the average age was higher (67.38 ? 14.63 vs. 61.38 ? 18.96 years; p < 0.001) and comorbidities were more common. Patients with elevated body temperature had a significantly lower degree of organ dysfunction measured by the Sequential Organ Failure Assessment score compared to afebrile patients. There were 29.2% of patients with lethal outcome in the group of afebrile patients compared to 18.4% of deceased febrile patients. Conclusion. We conclude that the absence of fever does not rule out the diagnosis of sepsis, but on the contrary, it is associated with greater organ dysfunction and higher mortality, while the elderly are a particularly vulnerable group.

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Trauma-Induced Systemic Inflammatory Response: A Comprehensive Review

Mileković

2023

JSRP

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Trauma is a noteworthy contributor to death and disability in adults. Its impact can extend to multiple organ systems via complex physiological reactions. This article comprehensively examines the physiological responses that transpire following trauma. It begins with the initial immune and inflammatory responses and advances to the possibility of sepsis and multi-organ dysfunction syndrome (MODS). The article delves into the roles of the innate and adaptive immune systems, the Systemic Inflammatory Response Syndrome (SIRS), and the various stages of sepsis. It emphasizes the importance of early detection and treatment, showcasing the benefit of the Injury Severity Score (ISS) to assess trauma severity and the Sequential Organ Failure Assessment (SOFA) scores to estimate sepsis severity. While acknowledging progress in understanding and identifying trauma-related conditions, the article emphasizes the importance of providing timely and accurate treatment to improve patient’s recovery.

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Development of the definition of sepsis

Cited by 3 publications

References 28 publications

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection–Sepsis Relationship

Fever and sepsis - dangerous controversies

Trauma-Induced Systemic Inflammatory Response: A Comprehensive Review

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