Development of the chick wing and leg neuromuscular systems and their plasticity in response to changes in digit numbers

Luxey, Maëva; Berki, Bianka; Heusermann, Wolf; Fischer, Sabrina; Tschopp, Patrick

doi:10.1016/j.ydbio.2019.10.035

Cited by 10 publications

(28 citation statements)

References 55 publications

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“…1A; Tickle et al, 1975;Riddle et al, 1993). Other tissues that are not derived from the lateral plate mesoderm, including the nerves and muscles, are duplicated as a secondary consequence (Luxey et al, 2020), and thus show equivalence (Lewis and Wolpert, 1976; i.e. progenitor cells are not intrinsically different in character and do not carry positional information).…”

Section: Introductionmentioning

confidence: 99%

Sonic hedgehog specifies flight feather positional information in avian wings

et al. 2020

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Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into specific patterns of Sim1 and Zic transcription factor expression, providing evidence of a putative gene regulatory network operating in flight feather patterning. Our data suggest that flight feather specification involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an embryonic process that played a fundamental step in the evolution of avian flight.

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Section: Introductionmentioning

confidence: 99%

Sonic hedgehog specifies flight feather positional information in avian wings

et al. 2020

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“…These short-range interactions within a restricted target region are likely to require a lesser number of guidance molecules. Lastly, the myriad number of nerves and nerve tracts observed in the mammalian PNS and central nervous system (CNS) highlights the importance of selective fasciculation and defasciculation in their complex wiring ( Chédotal and Richards, 2010 ; Luxey et al, 2020 ; Takahashi et al, 2010 ; Thiebaut de Schotten et al, 2015 ), and also suggests that the cellular strategy using selective fasciculation and defasciculation should increase the fidelity of axon pathfinding, even with the relatively small number of guidance molecules in mammals. Given that major classes of axon guidance molecules serve evolutionarily conserved guidance functions across the animal kingdom ( Bashaw and Klein, 2010 ; Dickson, 2002 ; Kolodkin and Tessier-Lavigne, 2011 ), in summary, the molecular and cellular mechanisms underlying selective fasciculation and defasciculation could be highly conserved from flies to mammals.…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanisms Underlying Motor Axon Guidance in Drosophila

Jeong

2021

Molecules and Cells

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Decoding the molecular mechanisms underlying axon guidance is key to precise understanding of how complex neural circuits form during neural development. Although substantial progress has been made over the last three decades in identifying numerous axon guidance molecules and their functional roles, little is known about how these guidance molecules collaborate to steer growth cones to their correct targets. Recent studies in Drosophila point to the importance of the combinatorial action of guidance molecules, and further show that selective fasciculation and defasciculation at specific choice points serve as a fundamental strategy for motor axon guidance. Here, I discuss how attractive and repulsive guidance cues cooperate to ensure the recognition of specific choice points that are inextricably linked to selective fasciculation and defasciculation, and correct pathfinding decision-making.

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“…However, it has been shown that the formation of distinct muscle bellies in the autopod is also a plastic process closely related to the formation of their corresponding skeletal and tendinous elements. 57 Notably, the segmentation of autopodial premuscle masses involves an intense death process. 39 In summary, the embryonic strategy used to build the different structural components of the limb can be divided into two periods: first, the formation of an excess mass of progenitors, which then, based on the differentiation signals, is segregated into a central component destined for to form the adult organ in question, and a peripheral population of progenitors that acts as a scaffold and is eliminated when it is no longer necessary to support the developing organ.…”

Section: Control and Biological Significance Of Cell Deathmentioning

confidence: 99%

“…The differentiation potential and plasticity of prospective dying cells in other areas of cell death of the embryonic limb have received little attention. However, it has been shown that the formation of distinct muscle bellies in the autopod is also a plastic process closely related to the formation of their corresponding skeletal and tendinous elements 57 . Notably, the segmentation of autopodial premuscle masses involves an intense death process 39 …”

Section: Control and Biological Significance Of Cell Deathmentioning

confidence: 99%

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Cell death in the developing vertebrate limb: A locally regulated mechanism contributing to musculoskeletal tissue morphogenesis and differentiation

Montero

Lorda‐Diez

Sánchez-Fernández

et al. 2020

Developmental Dynamics

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Our aim is to critically review current knowledge of the function and regulation of cell death in the developing limb. We provide a detailed, but short, overview of the areas of cell death observed in the developing limb, establishing their function in morphogenesis and structural development of limb tissues. We will examine the functions of this process in the formation and growth of the limb primordia, formation of cartilaginous skeleton, formation of synovial joints, and establishment of muscle bellies, tendons, and entheses. We will analyze the plasticity of the cell death program by focusing on the developmental potential of progenitors prior to death. Considering the prolonged plasticity of progenitors to escape from the death process, we will discuss a new biological perspective that explains cell death: this process, rather than secondary to a specific genetic program, is a consequence of the tissue building strategy employed by the embryo based on the formation of scaffolds that disintegrate once their associated neighboring structures differentiate.

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Development of the chick wing and leg neuromuscular systems and their plasticity in response to changes in digit numbers

Cited by 10 publications

References 55 publications

Sonic hedgehog specifies flight feather positional information in avian wings

Sonic hedgehog specifies flight feather positional information in avian wings

Molecular Mechanisms Underlying Motor Axon Guidance in Drosophila

Cell death in the developing vertebrate limb: A locally regulated mechanism contributing to musculoskeletal tissue morphogenesis and differentiation

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