Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study

Rink, Elke; Wullimann, Mario F.

doi:10.1016/s0165-3806(02)00354-1

Cited by 212 publications

(268 citation statements)

References 23 publications

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“…In zebrafish, the most prominent DA groups develop in a ventral diencephalic region called the posterior tuberculum (PT) (Rink and Wullimann, 2002). Within this domain, distinct DA cell clusters are detected starting at 1-day-old zebrafish embryos (Rink and Wullimann, 2002).…”

Section: Resultsmentioning

confidence: 99%

“…In zebrafish, the major clusters of DA neurons are found in the posterior tuberculum (PT), which is part of the basal diencephalon. Within the PT, there are several DA subgroups that have been categorized by their location, morphology, and neuronal projection (Holzschuh et al, 2001;Rink and Wullimann, 2002). There is a fair degree of conservation in DA circuits across fish, mice, and humans (Wullimann and Mueller, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

Borodovsky

Ponomaryov

Frenkel

et al. 2009

Developmental Dynamics

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

Borodovsky

Ponomaryov

Frenkel

et al. 2009

Developmental Dynamics

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“…The distribution and development of dopaminergic neurons during zebrafish embryogenesis has been studied recently (Guo et al, 1999;Holzschuh et al, 2001;Rink and Wullimann, 2002b). In mammals, dopaminergic neurons develop in the forebrain and midbrain.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have now described the organization and function of the dopamine system in zebrafish. Clusters of dopaminergic neurons have been identified in the developing embryo (Guo et al, 1999;Holzschuh et al, 2001;Rink and Wullimann, 2002b) and adult (Ma, 1994a(Ma, , b, 1997(Ma, , 2003. Immunocytochemical evidence suggests that zebrafish have a conserved dopaminergic projection pathway that is homologous to the human mesostriatal pathway (Rink and Wullimann, 2002a).…”

Section: Introductionmentioning

confidence: 99%

Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish

Boehmler

Obrecht-Pflumio

Canfield

et al. 2004

Developmental Dynamics

146

122

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We mined the zebrafish genomic sequence database and identified contigs containing segments of several dopamine receptor genes. By using a polymerase chain reaction amplification strategy, we generated full-length cDNAs encoding a single dopamine D3 receptor and three distinct D2 receptor subtypes. Zebrafish dopamine receptor genes were mapped by using the T51 radiation hybrid panel. The D3 receptor gene (drd3) mapped to linkage group (LG) 24. The three D2 receptor genes were localized to LG 15 (drd2a), LG 16, (drd2b), and LG 5 (drd2c). With the exception of the drd2b gene, each of these map positions was syntenic with regions of human chromosomes containing orthologs of the zebrafish dopamine receptor genes. Whole-mount in situ hybridization was used to investigate expression of the D2 and D3 receptor genes. Expression of the drd3 gene was first detected at mid-somitogenesis and was particularly prominent in somites. Thereafter, the drd3 gene was expressed diffusely throughout the brain and spinal cord. The three D2 receptor genes were expressed throughout the central nervous system (CNS) in distinct but overlapping patterns. In early embryos, the drd2a gene was expressed exclusively in the epiphysis, whereas the drd2c gene was localized to the notochord. After 24 hpf, the drd2a, drd2b, and drd2c genes were differentially expressed throughout the CNS. The identification of dopamine receptor genes in zebrafish should allow us to use the power of zebrafish genetics to analyze the functional properties of this important class of neurotransmitter receptors.

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“…CA development in zebrafish starts quite early, and most of the CA groups and axon tracts found in the adult brain can already be detected in 3-dpf larvae (29,38,43). The longitudinal axon tracts from dopaminergic neurons extend from the diencephalon toward the spinal cord in the vicinity of the MLF (see above for the role of Amigo1 in MLF formation) and lateral longitudinal fasciculus (LLF), but their formation may not depend on these early axonal scaffolds (38,42).…”

Section: Development Of Aminergic Circuits In Amigo1 Knockdownmentioning

confidence: 99%

Amigo Adhesion Protein Regulates Development of Neural Circuits in Zebrafish Brain

Zhao

Kuja-Panula

Sundvik

et al. 2014

Journal of Biological Chemistry

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Background: Amigos are transmembrane proteins suggested to mediate adhesive interactions of cells. Results: Down-regulation of Amigo protein expression or inhibition of its function results in defects of fiber pathway development and disturbed locomotor functions in zebrafish. Conclusion:The neural form of Amigo is required for construction of functional neural circuitries. Significance: Amigo is identified as a novel factor that regulates formation of neuronal connections.

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Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study

Cited by 212 publications

References 23 publications

Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish

Amigo Adhesion Protein Regulates Development of Neural Circuits in Zebrafish Brain

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