Development of the brain ventricular system from a comparative perspective

Korzh, Vladimir

doi:10.1002/ca.23994

Cited by 5 publications

(5 citation statements)

References 187 publications

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“…In mammals, each ventricle has one choroid plexus, with a total of four. In zebrafish, there has, only been two ChPs described so far based on anatomical and gene expression profiles, which are located in the forebrain and hindbrain (Garcia-Lecea et al ., 2008; Korzh, 2023). Given that the forebrain ChP is located between the pineal gland and the habenula and is nearby the subcommisural organ (Korzh, 2023), it most probably corresponds to the ChP of the 3 rd ventricle in mammals.…”

Section: Discussionmentioning

confidence: 99%

“…In zebrafish, there has, only been two ChPs described so far based on anatomical and gene expression profiles, which are located in the forebrain and hindbrain (Garcia-Lecea et al ., 2008; Korzh, 2023). Given that the forebrain ChP is located between the pineal gland and the habenula and is nearby the subcommisural organ (Korzh, 2023), it most probably corresponds to the ChP of the 3 rd ventricle in mammals. Interestingly, the forebrain ChP, but not the hindbrain ChP, folds into a complex 3D structure between the juvenile and adult stage, when the forebrain ChP expands steadily.…”

Section: Discussionmentioning

confidence: 99%

“…To date, however, studies in zebrafish have mainly focused on the development of the ChP. Prior work has revealed that zebrafish have two ChPs, which are located on the dorsal roof of the forebrain and hindbrain (Garcia-Lecea et al , 2008; Korzh, 2023). The ChPs appear during early embryonic stage (at circa 36 hour-post-fertilization (hpf)) (Garcia-Lecea et al ., 2008) and are composed of motile monociliated epithelial cells before eventually becoming a multiciliated organ at juvenile stage (D’Gama et al , 2021; Olstad et al , 2019).…”

Section: Introductionmentioning

confidence: 99%

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The evolutionary conserved choroid plexus sustains the homeostasis of brain ventricles in zebrafish

Jeong,

Andreassen,

Hoang

et al. 2023

Preprint

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SummaryThe choroid plexus produces cerebrospinal fluid (CSF) by transport of electrolytes and water from the vasculature to the brain ventricles. The choroid plexus plays additional roles in brain development and homeostasis by secreting neurotrophic molecules, and by serving as a CSF-blood barrier and immune interface. Prior studies have identified transporters on the epithelial cells that transport water and ions into the ventricles and tight junctions involved in the CSF-blood barrier. Yet, how the choroid plexus epithelial cells maintain the brain ventricle system and control brain physiology remain unresolved. To provide novel insights into the physiological roles of the choroid plexus, we use juvenile and adult zebrafish as model systems. Upon histological and transcriptomic analyses, we first identified that the zebrafish choroid plexus is highly conserved with the mammalian choroid plexus and that it expresses all transporters necessary for CSF secretion. Using novel genetic lines, we also identified that the choroid plexus secretes proteins into the CSF. Next, we generated a transgenic line allowing us to ablate specifically the epithelial cells in the choroid plexus. Using the ablation system, we identified a reduction of the ventricular sizes, but no alterations of the CSF-blood barrier. Altogether, our findings identified that the zebrafish choroid plexus is evolutionarily conserved and critical for maintaining the size and homeostasis of the brain ventricles.Graphical abstractHighlightsThe zebrafish choroid plexus has similar anatomical features with the mammalian choroid plexus.The expression of choroid plexus transporters involved in CSF secretion is evolutionarily conserved across vertebrates.Generation of a novel choroid plexus specific driver line shows that the choroid plexus epithelial cells secrete proteins into CSF.Ablation of the choroid plexus decreases the size of the brain ventricles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The evolutionary conserved choroid plexus sustains the homeostasis of brain ventricles in zebrafish

Jeong,

Andreassen,

Hoang

et al. 2023

Preprint

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“…Finally, zebrafish have choroid plexuses in charge of producing and modulating the CSF (Van Leeuwen et al, 2018;Korzh, 2023), which itself is in direct contact with the apical side of the RGCs. The specific roles of theses choroid plexuses and the CSF on adult neurogenesis also remain to be uncovered.…”

Section: Neurogenic Niches In the Adult Zebrafishmentioning

confidence: 99%

Homemade: building the structure of the neurogenic niche

Valamparamban,

Spéder

2023

Front. Cell Dev. Biol.

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Neural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their function and enables neurogenesis. The niche is made of a diversity of cell types, including neurons, glia and the vasculature, which are able to signal to and are structurally organised around neural stem/progenitor cells. While the focus has been on how individual cell types signal to and influence the behaviour of neural stem/progenitor cells, very little is actually known on how the niche is assembled during development from multiple cellular origins, and on the role of the resulting topology on these cells. This review proposes to draw a state-of-the art picture of this emerging field of research, with the aim to expose our knowledge on niche architecture and formation from different animal models (mouse, zebrafish and fruit fly). We will span its multiple aspects, from the existence and importance of local, adhesive interactions to the potential emergence of larger-scale topological properties through the careful assembly of diverse cellular and acellular components.

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“…Cilia are slender, membrane-enclosed protrusions of eukaryotic cells. Motile cilia drive essential physiological functions such as the breaking of the left-right symmetry in mammalian embryos 1 , fluid transport in the human respiratory tract, fallopian tubes, and cerebral cavities [2][3][4] as well as the locomotion of single cell micro swimmers like sperm and algae. The internal mechanical core of cilia is evolutionary conserved among eukaryotes and is called the axoneme.…”

Section: Introductionmentioning

confidence: 99%

Twist - torsion coupling in beating axonemes

Striegler,

Friedrich,

Diez

et al. 2024

Preprint

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Motile cilia and flagella are ubiquitous cell appendages whose regular bending waves pump fluids across tissue surfaces and enable single-cell navigation. Key to these functions are their non-planar waveforms with characteristic torsion. It is not known how torsion, a purely geometric property of the shape, is related to mechanical deformations of the axoneme, the conserved cytoskeletal core of cilia and flagella. Here, we assess torsion and twist in reactivated axonemes isolated from the green alga Chlamydomonas reinhardtii. Using defocused darkfield microscopy and beat-cycle averaging, we resolve the 3D shapes of the axonemal waveform with nanometer precision at millisecond timescales. Our measurements reveal regular hetero-chiral torsion waves propagating base to tip with a peak-to-peak amplitude of 22 °/μm. To investigate if the observed torsion results from axonemal twist, we attach gold nanoparticles to axonemes to measure its cross-section rotation during beating. We find that locally, the axonemal cross-section co-rotates with the bending plane. This co-rotation presents the first experimental evidence for twist-torsion coupling and indicates that twist waves propagate along the axoneme during beating. Our work thus links shape to mechanical deformation of beating axonemes, informing models of motor regulation that shape the beat of motile cilia.

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Development of the brain ventricular system from a comparative perspective

Cited by 5 publications

References 187 publications

The evolutionary conserved choroid plexus sustains the homeostasis of brain ventricles in zebrafish

The evolutionary conserved choroid plexus sustains the homeostasis of brain ventricles in zebrafish

Homemade: building the structure of the neurogenic niche

Twist - torsion coupling in beating axonemes

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