Development of the Biomaterials Technology for the Infection Resistance

Xu, Tengzhou; Zhou, C.; Chen, Zhaofeng; Fan, Yuxin; Mao, Haifeng

doi:10.2174/1381612824666180307121716

Cited by 6 publications

(4 citation statements)

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“…Such strategies involve the utilization of bioglassbased or graphene-based antibacterial matrix, nano-coated metallic ions. 118 Peptide-modified PLGA nanoparticles against oral biofilms have also shown success in a murine model of periodontitis. 119 Interestingly, polymer brush coatings have been proposed to link biomaterial surfaces with biological cues in order to modulate the response of adhering cells.…”

Section: Biological Modification Of Biomaterials To Modulate Inflammationmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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Control of inflammation is indispensable for optimal oral wound healing and tissue regeneration. Several biomaterials have been used to enhance the regenerative outcomes; however, the biomaterial implantation can ensure an immune-inflammatory response. The interface between the cells and the biomaterial surface plays a critical role in determining the success of soft and hard tissue regeneration. The initial inflammatory response upon biomaterial implantation helps in tissue repair and regeneration, however, persistant inflammation impairs the wound healing response. The cells interact with the biomaterials through extracellular matrix proteins leading to protein adsorption followed by recruitment, attachment, migration, and proliferation of several immune-inflammatory cells. Physical nanotopography of biomaterials, such as surface proteins, roughness, and porosity, is crucial for driving cellular attachment and migration. Similarly, modification of scaffold surface chemistry by adapting hydrophilicity, surface charge, surface coatings, can down-regulate the initiation of pro-inflammatory cascades. Besides, functionalization of scaffold surfaces with active biological molecules can down-regulate pro-inflammatory and pro-resorptive mediators’ release as well as actively up-regulate anti-inflammatory markers. This review encompasses various strategies for the optimization of physical, chemical, and biological properties of biomaterial and the underlying mechanisms to modulate the immune-inflammatory response, thereby, promoting the tissue integration and subsequent soft and hard tissue regeneration potential of the administered biomaterial.

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Section: Biological Modification Of Biomaterials To Modulate Inflammationmentioning

confidence: 99%

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

et al. 2021

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“…Bacterial adhesion to short-term devices has been successfully prevented. [35][36][37] The results of many studies have shown that common antibiotics usually only have lethal and inhibitory effects on bacteria, whereas AgNP has lethal effects on a variety of fungi, protozoa, and even viruses. Bacteria did not develop resistance to silver ions.…”

Section: Introductionmentioning

confidence: 99%

“…Ureteral scaffolds coated with norfloxacin, ciprofloxacin, and nitrofloxacillin were prepared by dipping them into drug solutions. Bacterial adhesion to short‐term devices has been successfully prevented 35–37 . The results of many studies have shown that common antibiotics usually only have lethal and inhibitory effects on bacteria, whereas AgNP has lethal effects on a variety of fungi, protozoa, and even viruses.…”

Section: Introductionmentioning

confidence: 99%

Degradation behavior of polylactic‐co‐glycolic acid and polycaprolactone with nanosilver scaffolds

Dou,

Zhang,

Zhou

et al. 2023

J of Applied Polymer Sci

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Ureteral stents are commonly used in clinical treatment of ureteral diseases. There were a series of complications, such as biofilms and crusts caused by bacteria after surgery. Therefore, biodegradable with bacteriostatic ureteral scaffolds would be the potential to solve above mentioned problems. In this study, nanosilver (AgNP) was added to the polylactic‐co‐glycolic acid (PLGA) and polycaprolactone (PCL) to prepare biodegradable antibacterial ureteral scaffold samples by 3D printing. The biocompatibility, antibacterial properties, degradability, and mechanical properties of samples were observed. The samples were under a strong inhibitory effect on both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and the higher the concentration of AgNP, the stronger the antibacterial effect. When the concentration of AgNP was 10%, the antibacterial effect was up to 100%. AgNP was released continually with the degradation of samples, which can achieve a continuous antibacterial effect. The breaking strength of the samples without and with AgNP were 6.08 ± 1.16 MPa and 26.02 ± 2.00 MPa. The mechanical properties of samples with AgNP were higher than those without AgNP. It provides a potential way to design ureteral scaffolds based on biodegradable polymers with AgNP in the clinic.

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“…4,5 However, it is very difficult to find novel and effective antibiotics to replace and/or supplement existing antibiotics. 6 In recent years, various materials such as polymers, 7,8 hydrogels, 9,10 antimicrobial peptides (AMPs), 11,12 inorganic nanomaterials 13,14 and other materials have been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

Guo¹,

Cao²,

Wang³

et al. 2021

IJN

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Introduction:With increases in implant infections, the search for antibacterial and biofilm coatings has become a new interest for orthopaedists and dentists. In recent years, graphene oxide (GO) has been extensively studied for its superior antibacterial properties. However, most of these studies have focused on solutions and there are few antibacterial studies on metal surfaces, especially the surfaces of cobalt-chromium-molybdenum (CoCrMo) alloys. ε-Poly -L-lysine (ε-PLL), as a novel food preservative, has a spectrum of antimicrobial activity; however, its antimicrobial activity after coating an implant surface is not clear. Methods: In this study, for the first time, a two-step electrodeposition method was used to coat GO and ε-PLL on the surface of a CoCrMo alloy. Its antibacterial and antibiofilm properties against S. aureus and E. coli were then studied. Results:The results show that the formation of bacteria and biofilms on the coating surface was significantly inhibited, GO and ε-PLL composite coatings had the best antibacterial and antibiofilm effects, followed by ε-PLL and GO coatings. In terms of classification, the coatings are antiadhesive and contact-killing/inhibitory surfaces. In addition to oxidative stress, physical damage to GO and electrostatic osmosis of ε-PLL are the main antibacterial and antibiofilm mechanisms. Discussion: This is the first study that GO and ε-PLL coatings were successfully prepared on the surface of CoCrMo alloy by electrodeposition. It provides a promising new approach to the problem of implant infection in orthopedics and stomatology.

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Development of the Biomaterials Technology for the Infection Resistance

Cited by 6 publications

References 0 publications

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration

Degradation behavior of polylactic‐co‐glycolic acid and polycaprolactone with nanosilver scaffolds

Coating CoCrMo Alloy with Graphene Oxide and ϵ-Poly-L-Lysine Enhances Its Antibacterial and Antibiofilm Properties

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