Development of tailored SPION-PNIPAM nanoparticles by ATRP for dually responsive doxorubicin delivery and MR imaging

Yar, Yasemin; Khodadust, Rouhollah; Akkoç, Yunus; Ütkür, Mustafa; Sarıtaş, Emine Ülkü; Gözüaçık, Devrim; Acar, Havva Yağcı

doi:10.1039/c7tb00646b

Cited by 49 publications

(25 citation statements)

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“…As reported in our previous article, SPION-PNIPAM with a crystal size of 7.2 � 2.7 nm, hydrodynamic size of 57 nm in water and an LCST at 38°C was synthesized. [40] Such small sizes are very critical to provide long-blood circulation time in the in vivo studies to prevent fast clearance of nanoparticles. This nanoparticle has about 84 wt% PNIPAM of a molecular weight (Mn) of 20.4 kDa (1.54 PDI).…”

Section: Etoposide Loaded Spion-pnipammentioning

confidence: 99%

Etoposide Loaded SPION‐PNIPAM Nanoparticles Improve the in vitro Therapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis

Erkısa

Arı

Ulku

et al. 2020

Chemistry & Biodiversity

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Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems to provide diverse options in this regard. Therefore, poly(N-isopropylacrylamide) (PNIPAM) coated superparamagnetic iron oxide nanoparticles (SPION) loaded with Etoposide were prepared in small sizes (57 nm) and with 3.5 % drug content to improve the efficiency of Etoposide in prostate cancer therapy. Sustained release of the drug was achieved, which found to be sensitive to low pH and high temperature. The anti-growth activity of SPION-PNIPAM-Etoposide formulation against metastatic prostate cancer cells (PC-3, LNCaP) were investigated by SRB assay, then, confirmed by ATP assay. Mode of cell death was evaluated by using flow cytometry analyses. A significant improvement of nanoformulated drug was observed at 5-10 μg/ml doses of the drug in both cell lines. More importantly, this formulation enhanced the cytotoxic effect of Etoposide on PC-3 cells, which is considered more resistant to Etoposide than LNCaP and reduced the IC 50 value by 55 % reaching to 4.5 μg drug/ml, which is a very significant improvement in the literature. It was clearly shown that nanoformulated drug provided about 3-fold increases in caspase-dependent early apoptotic cells in PC-3 cells. The novel formulation seems to successfully cause cell death of especially PC-3 metastatic prostate cancer cells. It should therefore be taken into consideration for further animal studies as a novel potent anticancer agent.

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Section: Etoposide Loaded Spion-pnipammentioning

confidence: 99%

Etoposide Loaded SPION‐PNIPAM Nanoparticles Improve the in vitro Therapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis

Erkısa

Arı

Ulku

et al. 2020

Chemistry & Biodiversity

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“…To unravel this difficulty, various strategies have been employed to prepare biodegradable or semi-degradable PNIPAM-based materials (135,160). In addition to polymeric materials, Aluminum oxide, and superparamagnetic Fe 2 O 3 nanoparticles have also been successfully modified with PNIPAM and reported for drug release applications (161,162). Protein release studies via PNIPAM and PEG-functionalized mesoporous silica nanoparticles reported recently (163).…”

Section: Thermo-responsive Polymersmentioning

confidence: 99%

A glimpse of biodegradable polymers and their biomedical applications

Shah

Vasava

2019

E-Polymers

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Over the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

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“…One potentially fruitful organic-inorganic marriage is, for example, the integration of thermo-responsive polymers with paramagnetic/superparamagnetic metal hosting particle architectures. These polymers can mediate a significant change in hydration and solubility with changes in temperature [54][55][56], and have been applied to thermo-responsive drug release [57][58][59][60]. The integration of an associated high resolution imaging mode, such as MR, would also facilitate a direct imaging of treatment efficacy by magnetic hyperthermia.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging

2019

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The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.

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Development of tailored SPION-PNIPAM nanoparticles by ATRP for dually responsive doxorubicin delivery and MR imaging

Abstract: Smart theranostic SPION-NIPAM produced in small sizes show high drug loading capacity and pH/temperature-sensitive release which is also influenced by PNIPAM molecular weight.

Cited by 49 publications

References 50 publications

Etoposide Loaded SPION‐PNIPAM Nanoparticles Improve the in vitro Therapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis

Etoposide Loaded SPION‐PNIPAM Nanoparticles Improve the in vitro Therapeutic Outcome on Metastatic Prostate Cancer Cells via Enhanced Apoptosis

A glimpse of biodegradable polymers and their biomedical applications

Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging

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