Development of T-cell large granular lymphocytic leukemia in the course of B-cell chronic lymphocytic leukemia with a causal relationship inferred from a flow cytometric analysis of the bone marrow aspirate

Plata, Andrew; Frame, James N.; Stuelpnagel, Jeremy; Juranovic, Tajana; Estalilla, Oscar C; Jelić, Tomislav

doi:10.7243/2052-7896-3-4

Cited by 1 publication

(2 citation statements)

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“…The decreased immunosurveillance accompanying CLL/SLL is well documented, and studies of cellular immunity in CLL/SLL patients have found reduced T-cell function with a paradoxical clonal expansion of CD8+ T cells [ 8 ] and increased circulating CD8+ T-cell counts [ 38 ]. Theoretically, this could increase the incidence of T-cell large granular leukemia in CLL/SLL patients, but only 2 cases of such an association are described in the literature [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…In rare cases, T-cell malignancies develop in patients with CLL/SLL. Single cases have been described of the combination of CLL/SLL and anaplastic large-cell lymphoma (ALCL) [ 2 , 3 ], T-cell large granular leukemia [ 4 , 5 ], subcutaneous panniculitis-like T-cell lymphoma [ 6 ], cutaneous gamma-delta T-cell lymphoma [ 7 ], mycosis fungoides [ 8 ], and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) [ 8 – 12 ]. As some of the cases have been reported a while back [ 13 – 17 ], not all the peripheral T-cell lymphomas (PTCLs) have been subclassified as per the most recent World Health Organization Classification [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter’s Syndrome: A Case Report and Literature Review

Gorodetskiy

Пробатова

Kondratieva

2017

Case Reports in Hematology

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Richter's syndrome is the development of high-grade non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In most patients with Richter's syndrome, the high-grade NHL is diffuse large B-cell lymphoma. Only a small minority of CLL/SLL patients develop T-cell malignancies. Herein, we describe a 40-year-old male patient presenting with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) in the submandibular salivary gland, two years after the diagnosis of CLL/SLL. The PTCL-NOS consisted of small lymphocytes, which complicated diagnosis. Immunohistochemical, cytological, and molecular studies allowed the correct diagnosis of composite lymphoma (SLL/PTCL-NOS) of the submandibular salivary gland. The PTCL-NOS had a cytotoxic phenotype and aberrant expression of CD79a. There was no evidence to suggest that the PTCL-NOS of the submandibular salivary gland developed from an intimately associated submandibular lymph node or by PTCL-NOS dissemination. A review of the literature and presented case suppose that the PTCLs developed following CLL/SLL have the cytotoxic phenotype and can clinically mimic typical Richter's syndrome.

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