Development of synthetic thrombus models to simulate stroke treatment in a physical neurointerventional training model

Wortmann, Nadine; Andersek, Thomas; Guerreiro, Helena; Kyselyova, Anna A.; Frölich, Andreas; Fiehler, Jens; Krause, Dieter

doi:10.1080/26895293.2022.2046181

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Accordingly, such vascular stenoses are treated by the catheter-based procedure of percutaneous transluminal angioplasty (PTA). Treatments are performed under a Digital Subtraction Angiography (DSA) to visualize the vessels under X-ray (Wortmann et al, 2022).…”

Section: Additive Manufacturing Of a Stroke Simulation Modelmentioning

confidence: 99%

“…The development and fabrication of the functional models of thrombus and stenosis were described in Wortmann et al, 2022 andWortmann et al, 2021b. For the thrombus models, AM was only considered as a support material for agarose models for replicating calcium-rich thrombi because the material properties of many additively manufactured materials were too solid to replicate the properties of thrombi (Wortmann et al, 2022).…”

Section: Additive Manufacturing Of a Stroke Simulation Modelmentioning

confidence: 99%

“…One of the following presented examples in medical technology is the development of individualized blood vessel models for a modular medical simulator used in medical training of neurovascular interventions. These additive manufactured models are used to replicate individual patient anatomy of intracranial and cervical vascular diseases like aneurysms (Spallek and Krause, 2017), ischemic strokes (Wortmann et al, 2022) or stenosis (vascular constrictions) (Wortmann et al, 2021b), to achieve a realistic training scenario for medical staff. A distinction is made between models that essentially represent the geometric properties, like aneurysm models, aortic model (Wortmann et al, 2021a) and functional models, as represented by the stenoses, which change their state (show an opening behavior) as a result of treatment.…”

Section: Introductionmentioning

confidence: 99%

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New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

Wegner

Hartwich

Heyden

et al. 2022

Front. Manuf. Technol.

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In this publication, the potentials of additive manufacturing in the field of sustainability and individualization for aviation and medical technology are presented. Design approaches for each application field as well as examples in the fields are shown. In the field of aviation, structures can be manufactured so that they are load path optimized. This has a great lightweight potential and results in a low resource consumption. The examples contain the design of an aircraft cabin partition using the Direct Energy Deposition process and the optimization of load introduction points directly integrated into the sandwich core. Furthermore, in medical technology, additive manufacturing can be used to produce patient-specific models based on original medical imaging data, which can be used for training of medical treatments, quality assurance or for the validation of new developed medical devices. As examples a stroke simulation model containing a modular aortic model as well as functional stenose models are shown. Furthermore, the use of AM molds to generate a deformable bladder shell and a prostate phantom are described.

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Section: Additive Manufacturing Of a Stroke Simulation Modelmentioning

confidence: 99%

Section: Additive Manufacturing Of a Stroke Simulation Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

Wegner

Hartwich

Heyden

et al. 2022

Front. Manuf. Technol.

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Fabrication of Shape Memory Polymer Endovascular Thrombectomy Device for Treating Ischemic Stroke

Kuram,

Karadeli

2024

Macromol. Rapid Commun.

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Stroke is the second result for death and ischemic stroke constitutes most of all stroke cases. Ischemic stroke takes place when blood clot or embolus blocks cerebral vessel and interrupts blood flow, which often leads to brain damage, permanent disability, or death. There is a 4.5‐hour (golden hour) treatment window to restore blood flow prior to permanent neurological impairment results. Current treatments of stroke consist mechanical system or thrombolytic drug therapy to disrupt or dissolve thrombus. Thrombolytics given more than 4.5 h after initial onset of symptoms are not effective on all thrombi. Also, the drugs may cause intracranial hemorrhage, which may be severe or fatal. New treatment modality should improve mortality rates and decrease morbidity. An effective treatment method should be easy, fast to deploy and resolve thrombus faster than current therapies. Promising method for treatment of stroke is mechanical retrieving of thrombi employing device deployed endovascularly. Advent of smart materials has led to research fabrication of several minimally invasive endovascular devices that take advantage of new materials capabilities. One of these capabilities is shape memory, is capability of material to store temporary form, then activate to primary shape as subjected to stimuli. Shape memory polymers (SMPs) have been employed as good materials for thrombectomy device fabrication. Therefore, current review presents thrombectomy device development with SMPs and fabrication of SMP‐based devices for improving stroke treatment is also described. Design, performance, limitations, and in vitro or in vivo clinical results of SMP‐based thrombectomy devices are identified. Furthermore, future directions of SMP‐based thrombectomy devices are highlighted. Review also sheds light on SMP's future outlook and recommendations for thrombectomy device application, opening a new era for advanced materials in materials science. This will demonstrate how new approaches can be achieved employing the latest trends in research world in the development of advanced SMP materials.This article is protected by copyright. All rights reserved

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Novel synthetic clot analogs for in-vitro stroke modelling

et al. 2022

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Purpose The increased demand for training of mechanical thrombectomy in ischemic stroke and development of new recanalization devices urges the creation of new simulation models both for training and device assessment. Clots properties have shown to play a role in procedural planning and thrombectomy device effectiveness. In this study, we analyzed the characteristics and applicability of completely synthetic, animal-free clots in the setting of an in-vitro model of mechanical thrombectomy for training and device assessment. Methods Synthetic clots based on agarose (n = 12) and silicone (n = 11) were evaluated in an in-vitro neurointervention simulation of mechanical thrombectomy with clot extraction devices. Calcified clots of mixed nature were simulated with addition of 3D printed structures. 9 clots were excluded due to insufficient vessel occlusion and failure to integrate with clot extraction device. Synthetic thrombi were characterized and compared using a categorical score-system on vessel occlusion, elasticity, fragmentation, adherence and device integration. Results Both agarose-based and silicone-based clots demonstrated relevant flow arrest and a good integration with the clot extraction device. Silicone-based clots scored higher on adherence to the vessel wall and elasticity. Conclusion Selected synthetic clots can successfully be implemented in an in-vitro training environment of mechanical thrombectomy. The clots’ different properties might serve to mimic fibrin-rich and red blood cell-rich human thrombi.

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Development of synthetic thrombus models to simulate stroke treatment in a physical neurointerventional training model

Cited by 3 publications

References 49 publications

New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

New Trends in Aviation and Medical Technology Enabled by Additive Manufacturing

Fabrication of Shape Memory Polymer Endovascular Thrombectomy Device for Treating Ischemic Stroke

Novel synthetic clot analogs for in-vitro stroke modelling

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