Development of Swine Models for Cancer Research:
            <scp>SCID</scp>
            Pigs and Other Emerging Pig Cancer Models

Boettcher, Adeline N.; Tuggle, Christopher K.

doi:10.1002/9781119535331.ch9

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Hematological Malignancies1

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2024

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“…Therefore, the compatibility of CD34 + between humans and pigs offers a potential therapeutic method. In addition, CD45 + cells, which are highly expressed in hematological malignancies [74], as they regulate T cell levels, were found in ART -/-IL-2RG -/Y pig bone marrow, liver, spleen, and thymic tissue [27]. Given immunological similarities between pigs and humans, pigs can serve as a viable and robust model to study human hematological cancer.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

Pigs: Large Animal Preclinical Cancer Models

Joshi,

Katam,

Hegde

et al. 2024

World J Oncol

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Pigs are playing an increasingly vital role as translational biomedical models for studying human pathophysiology. The annotation of the pig genome was a huge step forward in translatability of pigs as a biomedical model for various human diseases. Similarities between humans and pigs in terms of anatomy, physiology, genetics, and immunology have allowed pigs to become a comprehensive preclinical model for human diseases. With a diverse range, from craniofacial and ophthalmology to reproduction, wound healing, musculoskeletal, and cancer, pigs have provided a seminal understanding of human pathophysiology. This review focuses on the current research using pigs as preclinical models for cancer research and highlights the strengths and opportunities for studying various human cancers.

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Section: Hematological Malignanciesmentioning

confidence: 99%