Development of Sustained Release Drug Delivery System: A Review

Mandhar, Piyush; Joshi, G. J.

doi:10.21276/apjhs.2015.2.1.31

Cited by 22 publications

(19 citation statements)

References 8 publications

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“…The marketed topical products containing clindamycin are in solution and gel form, but they are meant to focus more on treating acne than the long-term inflammation associated with HS on the skin of patients. Moreover, there are some limitations observed on the conventional dosage forms, for instance, the necessity of frequent administration, especially for the drug with short half-life, fluctuations of the drug levels [ 23 ], as well as the higher chance of cross-contamination on the applicator. The approach for this study is to consider a formulation that could possess bioadhesion and a sustained-release effect to enhance the residence time for the drug at the site of skin, as the inflammation associated with HS stage I and mild stage II is mainly present at the epidermis and upper dermis layer [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…A combination of both natural and synthetic polymers can be used in the formulation to achieve the ideal condition. Some of the main advantages of in situ gel formulations include a sustained-release drug delivery system, ease of administration, reduction in the frequency of application, improvement in steady levels [ 23 ], and moreover, the prevention in cross-contamination as the formulation would be administered in spray form, meaning no contact was necessary on the applicator.…”

Section: Discussionmentioning

confidence: 99%

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Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

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Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

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“…Polimer alami seperti polisakarida, gum, kitosan, dan alginat dapat membentuk suatu spherical microbeads yang berpotensi sebagai alternatif penghantaran obat menjadi bentuk perilisan terkontrol (83,84) . Tujuan dari pelepasan terkontrol adalah untuk menjaga konsentrasi obat pada level yang tetap dalam periode waktu tertentu, untuk menurunkan frekuensi pemberian dosis, meningkatkan level keamanan dari obat, meningkatkan tingkat kepatuhan pasien, menurunkan fluktuasi, menurunkan efek samping lokal dan sistemik (85) , serta memperlama durasi aksi obat, dan memastikan respon farmakokinetik dan farmakodinamik dapat reprodusibel dan diprediksi. Selain itu, polimer dapat pula dimodifikasi sedemikian rupa untuk menjadi sistem penghantaran obat tertarget pada organ tertentu (83) .…”

Section: Pemanfaatan Kombinasi Polimerunclassified

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

et al. 2021

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Pengetahuan tentang sinergisme bermanfaat untuk menentukan kombinasi polimer alami yang memberikan efek menguntungkan ketika dikombinasikan. Interaksi yang saling menguntungkan antar polimer alami dapat dilihat dari nilai sinergisitas dari data pengujian viskositas. Kombinasi polimer yang memiliki efek sinergi dapat memberikan banyak kegunaan serta manfaat yang besar dalam pengembangan teknologi formulasi obat sehingga dapat mengatasi kekurangan yang dimiliki oleh masing-masing zat aktif obat. Pada studi ini, dilakukan review artikel tentang sinergisme kombinasi polimer, pengaruh kation sebagai cross-linker, serta aplikasi kombinasi alginat dengan polimer alami dalam formulasi sediaan obat dan aspek farmakologinya. Database yang digunakan untuk mengambil referensi, meliputi Scopus, PubMed, dan Google Schoolar. Tipe data dari database meliputi jurnal, artikel review, maupun buku tanpa ada pembatasan tahun. Referensi yang diperoleh dari database lalu diidentifikasi, dianalisis, dan dipilih yang sesuai dengan topik yang akan direview. Formulasi dengan polimer menghasilkan obat dengan pelepasan terkontrol, yang memiliki keuntungan, yakni dapat menurunkan frekuensi pemberian dosis, menurunkan efek samping obat, meningkatkan tingkat kepatuhan pasien, menurunkan fluktuasi, serta memperlama durasi aksi obat, dan memastikan respon farmakokinetik dan farmakodinamik dapat reprodusibel dan diprediksi. Selain itu, polimer dapat pula dimodifikasi sedemikian rupa untuk menjadi sistem penghantaran obat tertarget pada organ tertentu. Polimer alami yang paling banyak digunakan dan dikombinasikan dengan polimer lain adalah alginat karena memiliki struktur dengan banyak gugus negatif berupa karboksil dan hidroksil sehingga memiliki berbagai keuntungan, seperti dapat meningkatkan kelarutan obat, meningkatkan kemampuan mukoadesif, melepaskan obat secara terkontrol, serta menghantarkan obat pada target organ tertentu.

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“…Many oldest dosage forms suspension, emulsion, tablet capsules, suppositories, etc. have a few drawbacks, like drugs having a short half-life need repeated drug administration, which increases the like hood of skipping a dose of a drug resulting in fewer patient compliance [8]. Drug's steady-state level cannot be maintained in the body because of peak-valley due to absorption and elimination of the drug from the body and this would lead to underdose or overdose, as uniform drug amount increases or decrease above the range of therapeutic.…”

Section: Sustained-release Drug Deliverymentioning

confidence: 99%

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

Avhad

Gupta

2021

JPRI

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The sustained-release dosage form is a well-characterized and reproducible dosage form that is designed to control drug release profile at a certain rate to reach desired drug concentration in blood plasma or at the target site. There is immense demand in the market for new sustained-release formulations used for new drug molecules which release the drug at a sustained rate. Doxofylline is one of the widely useful drugs in the market and needs to be given in a single dose for a long duration of time. For the same, we have prepared a sustained released Doxofylline tablet. Aim: This research was done to design, formulate and evaluate Doxofylline sustained-release tablets by using different concentrations of Chitosan and Guar Gum. Methods: The factorial design was used to prepare Doxofylline sustained-release tablet. Doxofylline sustained-release tablets were prepared to employ different concentrations of Chitosan, Guar Gum, Lactose, and Magnesium Stearate in different combinations by wet granulation technique. Total 9 formulations were designed, formulated, and evaluated for the hardness, thickness, friability, % drug content, and in-vitro drug release. Results: A study of the release of drug by in-vitro found that F8 is to be the best efficient formulation which consists of both Chitosan and Guar Gum helped in delayed the release of drug up to 24 hours and performs excellent release of drug in starting hours of drug release in the body. The drug released from the F8 formulation indicates the kinetic model of First Order, by anomalous diffusion. The formulation F8 shows optimum thickness, hardness and at 40ºC±2 99.35% drug release after 24 hours shows optimum formulation. Conclusion: This study concludes that better drug release was observed by using natural polymers. Doxofylline with natural polymer shows good release and better dissolution rate as compared with a single synthetic polymer. Synthetic drug with natural polymer shows more future scope and this work will help the researcher in the future.

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Development of Sustained Release Drug Delivery System: A Review

Cited by 22 publications

References 8 publications

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

Formulation Development and Evaluation of Doxofylline Sustained-Release Tablets by Using Chitosan and Guar Gum

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