Development of sustainable antibacterial coatings based on electrophoretic deposition of multilayers: gentamicin-loaded chitosan/gelatin/bioactive glass deposition on PEEK/bioactive glass layer

Rehman, Muhammad Atiq Ur; Batool, Syeda Ammara

doi:10.1007/s00170-022-09024-3

Cited by 10 publications

(2 citation statements)

References 77 publications

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“…The R a of the composite coating (1.8 µm) was in the range of the reported value (1–2 µm) suitable for osteoblast attachment. The hydrophilic behavior of the coating also facilitated cell adhesion and proliferation [ 73 , 74 ]. Figure 13 B,C show the spreading of the cell on the surface of the composite coating after 2 and 7 days of incubation, respectively.…”

Section: Resultsmentioning

confidence: 99%

Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implants

Batool

Ahmad

Irfan

et al. 2022

JFB

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In recent years, natural polymers have replaced synthetic polymers for antibacterial orthopedic applications owing to their excellent biocompatibility and biodegradability. Zein is a biopolymer found in corn. The lacking mechanical stability of zein is overcome by incorporating bioceramics, e.g., mesoporous bioactive glass nanoparticles (MBGNs). In the present study, pure zein and zein/Zn–Mn MBGN composite coatings were deposited via electrophoretic deposition (EPD) on 316L stainless steel (SS). Zn and Mn were co-doped in MBGNs in order to make use of their antibacterial and osteogenic potential, respectively. A Taguchi design of experiment (DoE) study was established to evaluate the effect of various working parameters on the morphology of the coatings. It was observed that coatings deposited at 20 V for 5 min with 4 g/L concentration (conc.) of Zn–Mn MBGNs showed the highest deposition yield. Uniform coatings with highly dispersed MBGNs were obtained adopting these optimized parameters. Scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) were employed to investigate the morphology and elemental composition of zein/Zn–Mn MBGN composite coatings. Surface properties, i.e., coating roughness and wettability analysis, concluded that composite coatings were appropriate for cell attachment and proliferation. For adhesion strength, various techniques, including a tape test, bend test, pencil hardness test, and tensile test, were performed. Wear and corrosion analysis highlighted the mechanical and chemical stability of the coatings. The colony forming unit (CFU) test showed that the zein/Zn–Mn MBGN composite coating was highly effective against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) due to the presence of Zn. The formation of a hydroxyapatite (HA)-like structure upon immersion in the simulated body fluid (SBF) validated the in vitro bioactivity of the coating. Moreover, a WST-8 assay depicted that the MG-63 cells proliferate on the composite coating. It was concluded that the zein/Zn–Mn MBGN coating synthesized in this work can be used for bioactive and antibacterial orthopedic applications.

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Section: Resultsmentioning

confidence: 99%

Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implants

Batool

Ahmad

Irfan

et al. 2022

JFB

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“…The deposition of a coating represents an effective way to modify the superficial layers of a device without affecting its bulk. Chitosan-based materials, known for their good osteogenic and drug delivery properties, are being thoroughly investigated to improve implant bioactivity, antibacterial activity but also the protection of metallic parts from corrosion phenomena [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ti6Al4V mechanical and thermal surface modification on the adhesion of a chitosan-bioactive glass coating

Sanguedolce

Rotella

Curcio

et al. 2023

Int J Adv Manuf Technol

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Biomedical implants interact with human tissues introducing significant perturbation into the body. Implant surfaces can be then functionalized enabling better biocompatibility. At the same time, the additional use of a coating provides further functions such as corrosion protection, osteointegration, and drug delivery. In this context, a composite made of chitosan and bioactive glass nanoparticles has been used for coating Ti6Al4V alloy samples processed beforehand using different processes, i.e., polishing, milling, grit blasting, and electrical discharge machining. Experiments have been carried out to correlate substrate surface conditions and coating effectiveness in terms of scratch resistance with the final aim to obtain suitable guidelines to improve substrate-coating performances. Graphical Abstract

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Fabrication of surface modified antibacterial Ti6Al4V alloy powder reinforced gelatin/chitosan composite scaffold for tissue engineering applications

Venkatesan

Ganesan

Sreya

et al. 2023

Advanced Powder Technology

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Development of sustainable antibacterial coatings based on electrophoretic deposition of multilayers: gentamicin-loaded chitosan/gelatin/bioactive glass deposition on PEEK/bioactive glass layer

Cited by 10 publications

References 77 publications

Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implants

Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implants

Effects of Ti6Al4V mechanical and thermal surface modification on the adhesion of a chitosan-bioactive glass coating

Fabrication of surface modified antibacterial Ti6Al4V alloy powder reinforced gelatin/chitosan composite scaffold for tissue engineering applications

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