Development of Superparamagnetic Iron Oxide Nanoparticles (SPIOs)-Embedded Chitosan Microspheres for Magnetic Resonance (MR)-Traceable Embolotherapy

Kang, Myung Joo; Oh, Il Young; Choi, Byungchul; Kwak, Byung Kook; Lee, Jaehwi; Choi, Young Wook

doi:10.4062/biomolther.2009.17.1.98

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Since excessive exposure to X-rays is harmful [57], patients would be safer if physicians could observe their changes visually with reduced usage of them. Kang et al [58] used superparamagnetic iron oxide nanoparticles (SPIOs), nanocrystals of iron oxides coated with hydrophilic polymers, to achieve such an objective. SPIOs are originally used as a contrast agent for magnetic resonance imaging (MRI).…”

Section: Diversity Of Chitosan-based Local Drug Deliverymentioning

confidence: 99%

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

et al. 2017

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Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives.

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Section: Diversity Of Chitosan-based Local Drug Deliverymentioning

confidence: 99%

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

et al. 2017

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“…These ones comprise the possibility to incorporate iron oxide. In this context, superparamagnetic iron oxide nanoparticles embedded chitosan microspheres were developed for magnetic resonance (MR)-traceable embolotherapy with high resolution and sensitivity through magnetic resonance imaging (MRI) [ 62 ]. Superparamagnetic iron oxide nanoparticles loaded chitosan microspheres were prepared by emulsion and cross-linking technique and 100–200 μm sized spherical microsparticles were obtained.…”

Section: Biopharmaceutical Applicationsmentioning

confidence: 99%

Trojan Microparticles for Drug Delivery

2012

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During the last decade, the US Food and Drug Administration (FDA) have regulated a wide range of products, (foods, cosmetics, drugs, devices, veterinary, and tobacco) which may utilize micro and nanotechnology or contain nanomaterials. Nanotechnology allows scientists to create, explore, and manipulate materials in nano-regime. Such materials have chemical, physical, and biological properties that are quite different from their bulk counterparts. For pharmaceutical applications and in order to improve their administration (oral, pulmonary and dermal), the nanocarriers can be spread into microparticles. These supramolecular associations can also modulate the kinetic releases of drugs entrapped in the nanoparticles. Different strategies to produce these hybrid particles and to optimize the release kinetics of encapsulated drugs are discussed in this review.

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“…In recent times, several researchers have focused on polymer beads incorporated with iron oxide nanoparticles (SPIONs) of superparamagnetic. The magnetic polymer beads were found to be ideal as embolic agents for cancer embolism [4]. These magnetic beads can be detected and visualized mainly in the affected areas through magnetic resonance imaging (MRI) [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Alginate/Iron (III) Oxide Beads and Biofilm for Biomedical Applications

Zakhi

Idris

2022

KEM

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This research study focused on the fabrication and characterization of sodium alginate incorporated with iron (III) oxide in the form of beads and biofilm for biomedical application. The fabrication of the samples was carried out by using solution casting method and syringe pump extrusion technique. Beads and biofilm of sodium alginate incorporated with iron oxide were characterized by several characterization testing such as XRD, FTIR and contact angle measurement. From the XRD testing shows the diffraction peak that confirmed the cubic structure of Maghemite. Then, FTIR analysis shows the presence of several intermolecular and intramolecular bond stretching of sodium alginate. Lastly, contact angle measurement exhibits that alginate incorporated with iron oxide has hydrophilic behavior due to the contact angle less than 90Also, it was found that as the contact angle reduced as the weight of iron oxide increased.

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Development of Superparamagnetic Iron Oxide Nanoparticles (SPIOs)-Embedded Chitosan Microspheres for Magnetic Resonance (MR)-Traceable Embolotherapy

Cited by 6 publications

References 23 publications

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

Trojan Microparticles for Drug Delivery

Fabrication and Characterization of Alginate/Iron (III) Oxide Beads and Biofilm for Biomedical Applications

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