Development of <sup>177</sup>Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent

Shanehsazzadeh, Saeed; Grüttner, Cordula; Yousefnia, Hassan; Lahooti, Afsaneh; Gholami, Abdollah; Nosrati, Sahar; Zolghadri, Samaneh; Anijdan, Seyyed Hossein Mousavie; Lotfabadi, Alireza; Varnamkhasti, Behrang Shiri; Daha, Fariba Johari; Jalilian, Amir Reza

doi:10.1515/ract-2015-2499

Cited by 13 publications

(15 citation statements)

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“…In comparison with the intrinsic radiolabeling, the extrinsic radiolabeling is preferred for constructing molecular imaging probes bearing versatile biovectors, because it can be carried out under mild conditions. For example, radioisotopes including 64 Cu, [33,34] 111 In, [35] 177 Lu, [36] and 68 Ga, [37,38] 125 I, and 131 I [39][40][41] were attached to the particle surface through the secondary chelating group of the particle ligand or tyrosine moiety specifically for iodine radioisotopes. Despite the obvious advantages of these established methods, the radiolabeling stability still challenges the extrinsic labeling approaches.…”

Section: Introductionmentioning

confidence: 99%

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Chen

Huang

et al. 2021

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Radiolabeling counts for much in the functionalization of inorganic nanoparticles (NPs) because it endows NPs with high‐sensitive imaging capacities apart from providing accurate pharmacokinetic information on the labeled particles, which makes the development of relevant radiolabeling chemistry highly desirable. Herein, a novel Ligand Anchoring Group MEdiated RAdioLabeling (LAGMERAL) method is reported, in which a polyethylene glycol (PEG) ligand with a diphosphonate (DP) terminal group plays a key role. It offers possibilities to radiolabel NPs through the spare coordination sites of the DP anchoring group. Through X‐ray absorption spectroscopy studies, the coordination states of the foreign metal ions on the particle surface are investigated. In addition, radioactive Fe3O4 NPs are prepared by colabeling the particles with 125I at the outskirt of the particles through a phenolic hydroxyl moiety of the PEG ligand, and 99mTc at the root of the ligand, respectively. In this way, the stabilities of these types of radiolabeling are compared both in vitro and in vivo to show the advantages of the LAGMERAL method. The outstanding stability of probe and simplicity of the labeling process make the current approach universal for creating advanced NPs with different combinations of functionalities of the inorganic NPs and radioactive properties of the metal radioisotopes.

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Section: Introductionmentioning

confidence: 99%

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Chen

Huang

et al. 2021

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“…With regard to the excretion route, a minor accumulation in kidneys and a high liver and spleen uptake show that [ 68 Ga]Ga-MIONs are mainly cleared by the hepatobiliary system and not by renal excretion. Overall, the in vivo behavior of [ 68 Ga]Ga-MagP-NODAGA and [ 68 Ga]Ga-MagP MIONs in normal mice is similar to the biodistribution of nanoparticles with comparable physicochemical properties [ 5 , 52 , 54 ]. Despite the high uptake of [ 68 Ga]Ga-MIONs by the MPS organs, blood retention is satisfactory, which is encouraging for the continuation of studies in tumor-bearing mice.…”

Section: Resultsmentioning

confidence: 99%

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

et al. 2021

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The aim of this study was to develop a bioimaging probe based on magnetic iron oxide nanoparticles (MIONs) surface functionalized with the copolymer (p(MAA-g-EGMA)), which were radiolabeled with the positron emitter Gallium-68. The synthesis of the hybrid MIONs was realized by hydrolytic condensation of a single ferrous precursor in the presence of the copolymer. The synthesized MagP MIONs displayed an average Dh of 87 nm, suitable for passive targeting of cancerous tissues through the enhanced permeation and retention (EPR) effect after intravenous administration, while their particularly high magnetic content ascribes strong magnetic properties to the colloids. Two different approaches were explored to develop MIONs radiolabeled with 68Ga: the chelator-mediated approach, where the chelating agent NODAGA-NHS was conjugated onto the MIONs (MagP-NODAGA) to form a chelate complex with 68Ga, and the chelator-free approach, where 68Ga was directly incorporated onto the MIONs (MagP). Both groups of NPs showed highly efficient radiolabeling with 68Ga, forming constructs which were stable with time, and in the presence of PBS and human serum. Ex vivo biodistribution studies of [68Ga]Ga- MIONs showed high accumulation in the mononuclear phagocyte system (MPS) organs and satisfactory blood retention with time. In vivo PET imaging with [68Ga]Ga-MagP MIONs was in accordance with the ex vivo biodistribution results. Finally, the MIONs showed low toxicity against 4T1 breast cancer cells. These detailed studies established that [68Ga]Ga- MIONs exhibit potential for application as tracers for early cancer detection.

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“…121 By the simple addition of IONP@ PAA to an aqueous solution containing different As radioisotopes, the radiolabeling yield reached 92% after 24 h. PET images of mice revealed a strong signal from the liver, as opposed to free radioarsenic, which undergoes fast renal clearance and no liver uptake, confirming the stability of the newly formed SPION@As. Patrick et al further investigated the formation mechanism by using 111 In and 89 Zr and established that mineralization of the radiometal as an insoluble oxide was taking place on the surface of IONPs. 122 In addition to β emitters, IONPs were also recently radiolabeled with the α emitters 225 Ac and 223 Ra.…”

Section: Metal Oxidesmentioning

confidence: 99%

“…Tsotsalas and coauthors first investigated the stability of 111 In-radiolabeled zeolite L through simple K + /[ 111 In]In 3+ ion exchange. 158 A stability study in a physiological saline solution revealed that [ 111 In]In 3+ ions were re-exchanged with Na + cations from the solution, leading to In leaching, mostly due to the size difference between the pores and [ 111 In]In 3+ cations. A specifically designed molecular stopcock was then inserted to block the opening of the pores and prevent leaching.…”

Section: Metal Phosphatesmentioning

confidence: 99%

Inorganic Radiolabeled Nanomaterials in Cancer Therapy: A Review

Lemaître

Burgoyne

Ooms

et al. 2022

ACS Appl. Nano Mater.

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Cancer, one of the leading causes of death worldwide, remains a challenge to treat. Over the last decades, targeted therapies have emerged as a way to selectively target and treat the affected cells, leaving the healthy ones intact. Nanomaterials, with their high surface area, ease of functionalization, and interesting physicochemical properties, are seen as promising carriers for therapeutic radionuclides. Their optical, electronic, and magnetic properties can be supplemented by the emitted ionizing radiation to form theranostic (therapeutic and diagnostic) or combined therapeutic agents. This review describes how different relevant therapeutic radionuclides can be incorporated into inorganic nanoconstructs to be delivered to the cancer cells and their impact on tumors. Different types of nanomaterials as well as multiple ways of incorporating radionuclides and their impact on the stability and both in vitro and in vivo performances are discussed.

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Development of ¹⁷⁷Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent

Abstract: This study describes the preparation, biodistribution of

Cited by 13 publications

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Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

Inorganic Radiolabeled Nanomaterials in Cancer Therapy: A Review

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Development of 177Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent

Abstract: This study describes the preparation, biodistribution of

Cited by 13 publications

References 0 publications

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes

Chelator-Free/Chelator-Mediated Radiolabeling of Colloidally Stabilized Iron Oxide Nanoparticles for Biomedical Imaging

Inorganic Radiolabeled Nanomaterials in Cancer Therapy: A Review

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Development of ¹⁷⁷Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent