Development of strontium and magnesium substituted porous hydroxyapatite/poly(3,4-ethylenedioxythiophene) coating on surgical grade stainless steel and its bioactivity on osteoblast cells

Gopi, D.; Ramya, S.; Rajeswari, D.; Surendiran, M.; Kavitha, L.

doi:10.1016/j.colsurfb.2013.10.011

Cited by 59 publications

(53 citation statements)

References 46 publications

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“…The films restricted the penetration of the solution into the bulk substrate and thereby reduced the corrosive attack of chloride ions. The earlier corrosion study on ionic-doped HAP coatings shows the same kind of result [2]. Anawati et al [35] have suggested that coatings with open flaws, i.e., coatings with uncompressed structures such as HAP on Ti, allow free flow of species in the solution and liable access to O 2 which improves self-regeneration of protective oxide coatings and thereupon better corrosion protection.…”

Section: Corrosion Behaviormentioning

confidence: 77%

“…To further stimulate the bone-bonding ability, metallic implants are generally coated with osteoconductive biomaterials, such as hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) bioceramic [2,3]. Artificial synthetic HAP is extremely similar to the inorganic part of bones and the dentine of teeth, and it is non-toxic within any quantity and osteoconductive [4].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

et al. 2014

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This work elucidated the antibacterial efficacy, corrosion resistance, and cytotoxicity of electroplated copper-substituted hydroxyapatite (CuHAP) coating on titanium (Ti). The fabricated CuHAP coatings were characterized by scanning electron microscopy, energydispersive X-ray analysis spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction studies. The CuHAP coating had needle-like apatite crystals, the doping of Cu 2? into HAP reduced porosity, and the coating became denser. The CuHAP crystals were carbonated with a few of Cu 2? incorporation (about 0.80 wt%). The Cu 2? ions were homogenously deposited into HAP films. Potentiodynamic polarisation test revealed that the CuHAP coating provided good barrier characteristics and achieved superior corrosion protection for Ti substrates. The in vitro antibacterial activity of asprepared CuHAP coating was evaluated against Escherichia coli and was found to be effectively high against bacterial colonization. Bioactivity test conducted by soaking the coatings in simulated body fluid demonstrated that CuHAP coating can quickly induce bone-like apatite nucleation and growth. In vitro biocompatibility tests, MTT, were employed to assess the cytotoxicity of Cu-HAP coating with osteoblast-like MC3T3-E1 cells. The obtained HAP coating doped with a low content of Cu 2? exhibited good cytocompatibility and had no toxicity toward MC3T3-E1.

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Section: Corrosion Behaviormentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

et al. 2014

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“…19 The obtained results are well agreement with the literatures. 18,19 By comparing the spectra of PEDOT deposited on untreated and treated TNZ substrates, it can be clearly revealed that both spectra are very similar, which indicates that the chemical structure of the deposited lms on both substrates is the same.…”

Section: Structural Characterization Of Pedot Lms Synthesized On Trementioning

confidence: 99%

“…Gopi et al have synthesized PEDOT composite coatings on 316L SS implants through electrochemical route and the prepared coatings displayed promising result in in vitro biological studies. 18 Furthermore, the authors have also prepared the copolymer of PEDOT coatings on 316L SS implants using electrochemical approach and copolymer processed with 50 : 50 feed ratio exhibited high corrosion protection behavior with improved cell growth on MG63 osteoblast cell. 19 Recently, K. Catt et al reported the preparation of PEDOT composite coatings on Mg implants using electrochemical deposition and described the effective role of PEDOT coatings as anti-corrosion coatings on Mg implants using multiple mechanisms.…”

Section: -9mentioning

confidence: 99%

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

et al. 2018

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Surface treatment of metallic materials prior to the application of polymer coatings plays an important role in providing improved surface features and enhanced corrosion protection. In the current investigation, we aimed to evaluate the effect of surface treatment of newly developed TiNbZr (TNZ) alloys on the surface characteristics, including the surface topography, morphology, hydrophobicity and adhesion strength of subsequent poly(3,4-ethylenedioxythiophene) (PEDOT) coatings. The surface morphology, chemical composition, and surface roughness of both treated and coated alloys were characterized by scanning electron microscopy, energy dispersive spectroscopy, and optical profilometry, respectively. The adhesion strength of the coating was measured using a micro scratch machine. Furthermore, we also evaluated the performance of electrochemically synthesized PEDOT coatings on surface-treated TNZ alloys in terms of the surface protective performance in simulated body fluid (SBF) and in vitro bioactivity in osteoblast MG63 cells. Surface analysis findings indicated that the nature of the PEDOT coating (surface morphology, topography, wettability and adhesion strength) was intensely altered, while the surface treatment performed before electrodeposition facilitated the overall performance of PEDOT coatings as implant coating materials. The obtained corrosion studies confirmed the enhanced corrosion protection performance of PEDOT coatings on treated TNZ substrates. In vitro cell culture studies validated the improved cell adhesion and proliferation rate, further highlighting the important role of surface treatment before electrodeposition.

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“…Hydroxyapatite (HA; Ca 10 (PO 4 ) 6 (OH) 2 ) coatings are synthesized to enhance the biocompatibility and osteoconductiviy of biomaterials. HA has a structure similar to that of the major mineral constituent of human hard tissue and can form strong bonds with the tissue [8][9][10][11]. The surface of HA coatings with plate-like and porous structures can provide a relatively large surface area for improving chemical interaction with the biological environment.…”

Section: Introductionmentioning

confidence: 98%

Effect of Na+ and NaOH concentrations on the surface morphology and dissolution behavior of hydroxyapatite

Mao

Yang

Zhu

et al. 2015

Ceramics International

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Development of strontium and magnesium substituted porous hydroxyapatite/poly(3,4-ethylenedioxythiophene) coating on surgical grade stainless steel and its bioactivity on osteoblast cells

Cited by 59 publications

References 46 publications

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

Effect of Na+ and NaOH concentrations on the surface morphology and dissolution behavior of hydroxyapatite

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