Development of strain-specific SCAR marker for selection of Pleurotus eryngii strains with higher β-glucan

김수철,; 김혜수,; 조용운,; 류재산,; 조수정,

doi:10.14480/jm.2015.13.1.79

Cited by 2 publications

(1 citation statement)

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“…β-glucan is a group of polysaccharide that exists in the cell walls of yeasts, mushrooms, cereals, yeasts, algae, and bacteria, and has been explored as a bioactive substance [13,14]. Particularly it is present at high levels in medical mushrooms and plays an important role in immune functions of normal cellular tissues by stimulating B and T cells through the production of various cytokines [15]. Although α-glucan is the most widely known among those pullulans that are produced by Aureobasidium pullulans strain [16], this strain also produces β-1,3/1,6 glucan that has an excellent antitumor activity against allogeneic sarcoma-180 [17].…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of ¥ Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms

Kim

Lee

Kwon

et al. 2019

Journal of Microbiology and Biotechnology

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Atopic dermatitis (AD) is a chronic inflammatory skin disease of mainly infants and children. Currently, the development of safe and effective treatments for AD is urgently required. The present study was conducted to investigate the immunomodulatory effects of yeast-extracted β-1,3/1,6-glucan and/or Lactobacillus plantarum (L. plantarum) LM1004 against AD-like symptoms. To purpose, β-1,3/1,6-glucan and/or L. plantarum LM1004 were orally administered to AD-induced animal models of rat (histamine-induced vasodilation) and mouse (pruritus and contact dermatitis) exhibiting different symptoms of AD. We then investigated the treatment effects on AD-like symptoms, gene expression of immune-related factors, and gut microbiomes. Oral administration of β-1,3/1,6-glucan (0.01 g/kg initial body weight) and/or 2 × 10 1 2 cells/g L. plantarum LM1004 (0.01 g/kg initial body weight) to ADinduced animal models showed significantly reduced vasodilation in the rat model, and pruritus, edema, and serum histamine in the mouse models (p < 0.05). Interestingly, β-1,3/1,6glucan and/or L. plantarum LM1004 significantly decreased the mRNA levels of Th2 and Th17 cell transcription factors, while the transcription factors of Th1 and Treg cells, galactin-9, filaggrin increased, which are indicative of enhanced immunomodulation (p < 0.05). Moreover, in rats with no AD induction, the same treatments significantly increased the relative abundance of phylum Bacteroidetes and the genus Bacteroides. Furthermore, bacterial taxa associated with butyrate production such as, Lachnospiraceae and Ruminococcaceae at family, and Roseburia at genus level were increased in the treated groups. These findings suggest that the dietary supplementation of β-1,3/1,6-glucan and/or L. plantarum LM1004 has a great potential for treatment of AD as well as obesity in humans through mechanisms that might involve modulation of host immune systems and gut microbiota.

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