Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture

Câmara, Marcela Candido; Campos, Estefânia Vangelie Ramos; Monteiro, Raimundo Nonato Farias; Pereira, Anderson do Espírito Santo; Proença, Patrícia Luiza de Freitas; Fraceto, Leonardo Fernandes

doi:10.1186/s12951-019-0533-8

Cited by 214 publications

(124 citation statements)

References 98 publications

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“…Thus, the controlled release of active ingredients in agrochemicals aims to address the problems associated with the excessive usage of agrochemicals by reducing the quantiies and frequency application in the field. The agrochemical release from the chitosan matrix can be triggered by two types of stimuli: (1) biotic stress, such as the presence of plant pathogens (fungi and bacteria), nematodes, insects, pest and weeds; and (2) abiotic stress factors, such as pH, temperature, salinity, flooding, drought and other environmental factors [7,24].…”

Section: Controlled Release Formulationsmentioning

confidence: 99%

“…The release mechanism upon stimulus-response is through pore diffusion, surface desorption, capsule swelling and degradation, as illustrated in Figure 1 [7,25]. The diffusion-controlled mechanism relies on a diffusion rate gradient while the surface desorption refers to the active ingredient adsorbed on the surface of the nanoformulation.…”

Section: Controlled Release Formulationsmentioning

confidence: 99%

“…Alongside their benefits, agrochemicals are also known for their toxic properties, hence posing a threat to living organisms in the soil and rivers due to losses during their application via degradation, volatilization, photolysis and leaching. Furthermore, only 0.1% of the applied agrochemicals are 2 of 22 delivered to the particular target site and act effectively against the target organism (i.e., insect, bacteria, fungi, or virus) [7].…”

Section: Introductionmentioning

confidence: 99%

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Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection

Maluin

2020

Molecules

149

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The rise in the World’s food demand in line with the increase of the global population has resulted in calls for more research on the production of sustainable food and sustainable agriculture. A natural biopolymer, chitosan, coupled with nanotechnology could offer a sustainable alternative to the use of conventional agrochemicals towards a safer agriculture industry. Here, we review the potential of chitosan-based agronanochemicals as a sustainable alternative in crop protection against pests, diseases as well as plant growth promoters. Such effort offers better alternatives: (1) the existing agricultural active ingredients can be encapsulated into chitosan nanocarriers for the formation of potent biocides against plant pathogens and pests; (2) the controlled release properties and high bioavailability of the nanoformulations help in minimizing the wastage and leaching of the agrochemicals’ active ingredients; (3) the small size, in the nanometer regime, enhances the penetration on the plant cell wall and cuticle, which in turn increases the argochemical uptake; (4) the encapsulation of agrochemicals in chitosan nanocarriers shields the toxic effect of the free agrochemicals on the plant, cells and DNA, thus, minimizing the negative impacts of agrochemical active ingredients on human health and environmental wellness. In addition, this article also briefly reviews the mechanism of action of chitosan against pathogens and the elicitations of plant immunity and defense response activities of chitosan-treated plants.

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Section: Controlled Release Formulationsmentioning

confidence: 99%

Section: Controlled Release Formulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection

Maluin

2020

Molecules

149

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“…Stimuli-responsive CRFs provide advanced and smart controlled release of pesticides, where the CRFs present responses to small external stimuli, resulting in changes in their chemicalor physical properties favoring the “on-demand” release of loaded pesticides [ 18 ]. Until now, several kinds of stimuli responsive CRFs have been fabricated using abiotic or biotic stimuli, such as enzymes [ 13 ], redox [ 19 ], pH [ 20 ], temperature [ 21 ] and light [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

et al. 2020

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Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.

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“…Recently, in phytonanotechnology, plants have been tuned positively by the intrinsic properties of nanoparticles (NPs), such as electron conductivity (improved the electron transport rate of photosystem 1 by 8.8%) [2], ROS scavenging [3], water/nutrient retention/supply [4], and genetic manipulation [5,6]. Furthermore, NPs loaded with the chemical active ingredients have also extended the scope of microsurgery in plants through triggered release [7][8][9]. To understand the physiological consequences [10][11][12], a comparison of the vascular uptake of NPs was carried out.…”

Section: Introductionmentioning

confidence: 99%

A non-classical route of efficient plant uptake verified with fluorescent nanoparticles and root adhesion forces investigated using AFM

sharma

Muddassir

Muthusamy

et al. 2020

Preprint

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Background : Classical plant uptake is limited to water soluble or dispersible material. Further, the knowledge of adhesion and uptake of hydrophobic particles is limited to mammalian and bacterial cells, but not studied in plants; so here first time, we tested the fate of hydrophobic particles (oleylamine coated Cu 2-x Se NPs) in comparison to hydrophilic particles (chitosan coated Cu 2-x Se NPs) by treatment on the plant roots and studied the mechanism behind the uptake. Further, Cu 2-x Se NPs are one of the most popular nanomaterial which has been used in various fields viz., electrical, semiconductor industries, biomedicine and in sensing. However, the effects of these NPs on plants have been seldom studied. So here, along with polarity-based uptake, the toxicity of these NPs is investigated in a model plant, tomato. Results : Here, hydrophobic NPs have been found to be ~1.3 times more efficient than hydrophilic NPs in tomato plant root penetration. An atomic force microscopy (AFM) adhesion force experiment confirms that hydrophobic NPs experience non-spontaneous yet energetically favourable root trapping and penetration. Further, a relative difference in the hydrophobic vs. hydrophilic NPs movement from the roots to shoots is observed and found related to the change in the protein corona identified by 2D-PAGE analysis. Finally, the toxicity assays showed that Cu 2-x Se NPs lead to non-significant toxicity as compared to control.Conclusions : The enhanced uptake of hydrophobic NPs by the roots proves that non-classical forced penetration is more efficient. Hence, this enhanced uptake and sedentary behaviour of hydrophobic NPs in root can be adopted for eco-friendly leach-proof fertilizer application.

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Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture

Cited by 214 publications

References 98 publications

Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection

Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection

Coumarin-Containing Light-Responsive Carboxymethyl Chitosan Micelles as Nanocarriers for Controlled Release of Pesticide

A non-classical route of efficient plant uptake verified with fluorescent nanoparticles and root adhesion forces investigated using AFM

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