Development of steroidogenesis in the fetal rat adrenal gland: An in vitro study

R, Klepac; Milković, Karmela; Milković, S.

doi:10.1016/0022-4731(77)90092-9

Cited by 17 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the rat, adrenalectomy of the mother leads to an increase of foetal adrenal weight (Ingle and Fisher, 1938 ;Walaas and Walaas, 1944 ;Angervall, 1962 ;Klepac et al, 1977) and to an augmentation in foetal corticosteroid concentrations (Thoman et al, 1970 ;Cohen and Brault, 1974 ;Klepac et al, 1977 ;Arishima et al, 1977). Conversely, the stimulation of maternal corticosteroid secretion reduces the development of foetal adrenal glands (Milkovic and Domac, 1973 ; and decreases their in vitro steroidogenesis (Klepac et al, 1977). The decrease of the duration of pregnancy, observed after adrenalectomy, agrees with this interpretation ; the decrease is more or less pronounced according to the light regime.…”

mentioning

confidence: 99%

Influence of photoperiod on the time of parturition in the rat. I. — Effect of the length of daily illumination on normal or adrenalectomized animals

Bosc¹,

Nicolle²

1980

Reprod. Nutr. Dévelop.

View full text Add to dashboard Cite

Summary. Four groups of normal rats have been studied to elucidate the effect on the time of birth of four different light regimes applied throughout pregnancy (day 1 : beginning of pregnancy). The results showed that the time of parturition (onset of expulsion) depended on the light treatment : the longer the duration of the daily illumination, the longer pregnancy lasted. With a 14 hrs light regime, the births occurred during two main periods : 50 p. 100 before 8 p.m. on (Signoret, 1969) rats (Naaktgeboren and Slijper, 1970) and humans (Kaiser and Halberg,1962). In the rat, a specific effect of light on the time of parturition has been suggested in experiments involving shifts of the light/dark cycle (Lincoln and Porter, 1976) or different lengths of daily illumination (Plaut et al., 1970 ;Mitchell and Yochim, 1970 (Boer et al., 1975 ;Cohen, 1976).Attempts to establish if the pineal gland was involved in this effect of light in the rat have been unsuccessful Lincoln and Doyle, 1978) (Krieger, 1974 ;Ixart et al.,1977). Parturition was found to occur invariably during the period when the corticosterone levels were minimal for two different photoperiodic treatments (Lincoln and Porter, 1979). Some studies have also suggested that these adrenal secretions play a role in the initiation of parturition (Yoshinaga, 1978), even if there are controversial interpretations as to the action of the fetal hypophyseal-adrenal axis on the duration of pregnancy in this species (Swaab et al., 1977). Metopirone which inhibits 11! and 18 steroid hydroxylase activity, passes through the placenta (Dupouy, 1972) and leads to a prolongation of gestation (Parvez et al., 1972 (Fuchs, 1969) since the duration of expulsion varies and seems independent of the day of parturition (Boer et al.,1975 figure 3. Under the control light regime (14L-10D) parturition occurred earlier in the adrenalectomized rats (group CA-) than in the corresponding rats (group C ; P < 0.05). Thus, 17.4 (Plaut et ai., 1970 ;Boer et al., 1975 ;Cohen, 1976 ;Lincoln and Porter, 1976)

show abstract

mentioning

confidence: 99%

Influence of photoperiod on the time of parturition in the rat. I. — Effect of the length of daily illumination on normal or adrenalectomized animals

Bosc¹,

Nicolle²

1980

Reprod. Nutr. Dévelop.

View full text Add to dashboard Cite

show abstract

“…It is known that a high amount of maternal corticosterone (3,4) or progesterone adminis tered to pregnant rats on the last days of pregnancy prolongs pregnancy (6)(7)(8). In this study we injected progesterone to female rats on days 21 and 22 of pregnancy and analyzed in vitro growth and the steroidogenic capacity of fetal adrenal glands in prolonged pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Fetal Rat Adrenal Gland Steroidogenesis in vitro in Prolonged Pregnancy

R¹

1981

Neonatology

Self Cite

View full text Add to dashboard Cite

Progesterone, injected into pregnant rats on the last days of pregnancy, prolonged pregnancy and prevented parturition. The fetuses from mothers whose pregnancies were prolonged have greater body and adrenal weights on days 23 and 24 of gestation as compared with 1- and 2-day-old rats. The adrenal glands of fetuses and neonatal rats converted in vitro 4-¹⁴C-progesterone to 11-deoxycorticosterone (DOC), corticosterone (B), 18-hydroxy-11-deoxycorticosterone (18-OH-DOC), 18-hydroxy-corticosterone (18-OH-B) and aldosterone. The fetal adrenal glands on the 23rd and 24th day of pregnancy synthesized in vitro less DOC, corticosterone and 18-OH-DOC than the adrenal glands of intact neonatal rats. These results demonstrated that progesterone in prolonged pregnancy inhibited enzymes of steroid hydroxylation which converted progesterone to DOC, corticosterone and 18-OH-DOC in fetal rat adrenal glands.

show abstract

“…The conversion of steroids from 4-'4C progesterone in pairs of incubated adrenal glands was studied by the previous described procedure ( Klepac and Milkovic, 1975;Klepac et al, 1977Klepac et al, , 1979. The radioactive steroid hormones were developed after thin-layer chromatography and detected following autoradiog raphy on X-ray films.…”

Section: Methodsmentioning

confidence: 99%

Fetal Rat Adrenal Growth and Steroidogenesis <i>in vitro </i>after Maternal Dexamethasone Treatment

R¹,

Milković²

1979

Neonatology

Self Cite

View full text Add to dashboard Cite

Two groups of female rats were treated with dexamethasone phosphate (DEX) for 24 h. One group received DEX in drinking water (10 μg/ml) on the 15th day of pregnancy (DEX_15–16), and the second group on the 17th day of pregnancy (DEX_17–18). The mothers and fetuses were sacrificed on the 20th and 22nd days of pregnancy. DEX reduced adrenal weights and concentration of corticosterone in plasma of the treated females and their fetuses. Fetal body weight was also reduced. However, the lightest adrenal glands were found in fetuses of the DEX_17–18 mothers. Furthermore, the 19-day-old fetuses belonging to the DEX_17–18 mothers had smallest amounts of corticosterone in plasma, and in plasma, and their adrenal glands produced the lowest amounts of radioactive corticosterone, 11-deoxycorticosterone and 18-hydroxy-ll-deoxycorticosterone from 4-¹⁴C progesterone after 1 h of incubation in vitro. In the 21-day-old fetuses belonging to both the groups of treated mothers, the production of steroids by the adrenal glands was similar and to the same extent reduced in comparison to the control fetuses.

show abstract

Development of steroidogenesis in the fetal rat adrenal gland: An in vitro study

Cited by 17 publications

References 16 publications

Influence of photoperiod on the time of parturition in the rat. I. — Effect of the length of daily illumination on normal or adrenalectomized animals

Influence of photoperiod on the time of parturition in the rat. I. — Effect of the length of daily illumination on normal or adrenalectomized animals

Fetal Rat Adrenal Gland Steroidogenesis in vitro in Prolonged Pregnancy

Fetal Rat Adrenal Growth and Steroidogenesis <i>in vitro </i>after Maternal Dexamethasone Treatment

Contact Info

Product

Resources

About