Development of stereotactically guided laser interstitial thermotherapy of breast cancer: In situ measurement and analysis of the temperature field in ex vivo and in vivo adipose tissue

Perspectives of Breast Cancer Thermotherapies

“…Since thermal ablation alone is usually sufficient to destroy breast tumor tissues, it is often not combined with other types of BC treatments. Thermoablation enables to treat localized breast tumors of small sizes (2 to 6 cm), 35-37, 39-47 and more rarely metastatic liver tumors originating from BC, 38. During the treatment, the tumor temperature is typically raised to 90-95 ºC during 10 to 15 minutes using radiofrequencies, 35,37, or to 46-50 ºduring 60 seconds using microwaves, 38, to 60-90 ºC during one to two hours using high intensity focused ultrasound (HIFU), 44, 45, or to 48 ºC during 30 minutes using interstitial laser thermotherapy (ILT or LITT), 48.…”

Conductive interstitial thermal therapy device for surgical margin ablation:In vivoverification of a theoretical model

“…Thermal ablation of tumours and margins is gaining acceptance as complementary treatment in the management of solid tumours [2,22,23,25,26,[74][75][76][77][78][79]. Herein we present a patented device, conductive interstitial thermal therapy device (CITT), for soft tissue ablation [39,40].…”

“…Thermal ablation techniques, such as radiofrequency ablation [15][16][17][18][19][20][21][22], laser ablation [10][11][12][13][14][23][24][25][26], cryotherapy [27,28], and focused ultrasound with MRI guidance [1,[29][30][31][32][33][34], have shown promising results by destroying cancer cells via thermal energy delivery to target tissue. A common denominator among all these techniques, excluding cryotherapy, is that electromagnetic or acoustic energy is selectively absorbed by various tissue components and is converted to heat.…”

Penetrating effect of high-intensity infrared laser pulses through body tissue

“…37 The same research group adopted the abovementioned correction for temperature monitoring during LLLT treatment for breast cancer. [38][39][40] Recently, van Nimwegen et al performed temperature monitoring with TCs during Nd:YAG laser treatment on a canine prostate. 25 The rapid response of TCs enabled real-time monitoring of local temperatures with a delay of less than 1 ms. 41,42 Among these techniques, non-invasive thermometry commonly has unavoidable measurement errors caused by patient motion during in vivo applications, and its spatial resolution is limited by the size of pixels, the signal-to-noise ratio, as well as the type of tissue under investigation.…”