Development of stem cell therapy for stress urinary incontinence

Autologous muscle‐derived cells for the treatment of female stress urinary incontinence: A 2‐year follow‐up of a polish investigation

“…Tissue‐committed SC have been demonstrated to differentiate into properly functioning smooth and striated muscle tissue . The results of animal studies using SC isolated and expanded from a muscle biopsy and periurethrally injected into animals that had irreversible urethral injury or urethral denervation demonstrated that cells survived, formed new myotubes and restored the function of the urethral sphincter . Repairing lower urinary tract defects with correctly functioning host tissue, without introducing artificial materials or the risk of denervation or revascularization, seems to be the ideal approach .…”

Autologous Adipose Stem Cells in Treatment of Female Stress Urinary Incontinence: Results of a Pilot Study

“…To the best of our knowledge, ASCs have not been previously used clinically for female SUI treatments. However, nowadays stem cell therapies have been under extensive research [15], and prior to this study, some clinical studies on cell‐based injection therapies have been published. Mitterberger et al [16, 17] demonstrated an efficacy of cell‐based injection therapy using myoblasts and fibroblasts mixed with Contigen to treat female SUI.…”

“…However, the primary cells are not the optimal choice because of the difficulties in high‐yield expansion of cells. In addition to primary cells, autologous muscle‐derived stem cells and allogenic umbilical cord blood stems cells (CBSCs) have both been used in a few clinical trials to treat female SUI patients with promising results [8, 15]. Carr et al [18] used autologous MDSCs to treat 8 female SUI patients.…”

“…These treatments were demonstrated to be a safe method, and no severe adverse effects were detected. When compared with the aforementioned cell sources, the main advantage of ASCs is that the yield of stem cells from adipose tissue is much higher, and the isolation and expansion of ASCs is also relatively easy [15, 21]. Furthermore, the injection therapy with ASCs was detected as a potential method to treat male urinary incontinence [22], and therefore we wanted to study the efficacy of ASCs for female urinary incontinence.…”

Recent status of the treatment of stress urinary incontinence

“…The initial results from the investigation into the safety and efficacy of urethral injections of autologous total nucleated cells along with platelets seem to be promising . Although stem cell therapy holds much promise for SUI, the clinical applications in patients have been slow to materialize …”