Development of Standard Reference Samples of Aqueous Fullerene Dispersions

Mikheev, Ivan V.; Kareev, Ivan E.; Бубнов, В. П.; Volkov, Dmitry S.; Korobov, M.V.; Проскурнин, М. А.

doi:10.1134/s106193481809006x

Cited by 4 publications

(4 citation statements)

References 93 publications

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“…The present study was completed on fibrils which were formed from globular amyloid-prone proteins, insulin and lysozyme. The disaggregation ability of C 60 -NMP and C 70 -NMP on amyloid aggregates formed by other proteins, for example natively “unfolded” Aβ peptide, is currently unknown and required further investigations …”

Section: Discussionmentioning

confidence: 99%

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Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial

Šipošová

Петренко

Ivankov

et al. 2020

ACS Appl. Mater. Interfaces

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Nowadays, determining the disassembly mechanism of amyloids under nanomaterials action is a crucial issue for their successful future use in therapy of neurodegenerative and overall amyloid-related diseases. In this study, the antiamyloid disassembly activity of fullerenes C60 and C70 dispersed in 1-methyl-2-pyrrolidinone (NMP) toward amyloid fibrils preformed from lysozyme and insulin was investigated using a combination of different experimental techniques. Thioflavin T fluorescence assay and atomic force microscopy were applied for monitoring of disaggregation activity of fullerenes. It was demonstrated that both types of fullerene-based complexes are very effective in disassembling preformed fibrils, and characterized by the low apparent half-maximal disaggregation concentration (DC50) in the range of ∼22–30 μg mL–1. Small-angle neutron scattering was employed to monitor the different stages of the disassembly process with respect to the size and morphology of the aggregates. Based on the obtained results, a possible disassembly mechanism for amyloid fibrils interacting with fullerene/NMP complexes was proposed. The study is a principal step in understanding of the fullerenes destruction mechanism of the protein amyloids, as well as providing valuable information on how macromolecules can be engineered to disassemble unwanted amyloid aggregates by different mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…The disaggregation ability of C 60 -NMP and C 70 -NMP on amyloid aggregates formed by other proteins, for example natively "unfolded" Aβ peptide, is currently unknown and required further investigations. 31…”

Section: ■ Conclusionmentioning

confidence: 99%

Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial

Šipošová

Петренко

Ivankov

et al. 2020

ACS Appl. Mater. Interfaces

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“…Given the widespread use of this method, it is important to try to standardize the synthetic protocol. Such attempts were made by Mikheev et al, who prepared standard samples of fullerene hydrosols [206,207]. Note that in these works as well in the study by Kyzyma et al [186], sonication was used not only for the toluene-water system, but also during the preparation of the initial toluene solution of fullerenes.…”

Section: Hydrosols Of Fullerenes: Preparationmentioning

confidence: 99%

Colloid Chemistry of Fullerene Solutions: Aggregation and Coagulation

Mchedlov-Petrossyan,

Marfunin,

Kriklya

2023

Liquids

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This review article is devoted to the colloidal properties of fullerene solutions. According to generally accepted understandings, all solvents in relations to fullerenes are divided into “good”, “poor”, and “reactive”. We have consistently considered the state of fullerenes in these systems. In “good”, predominantly non-polar aromatic solvents and CS2, non-equilibrium dissolution methods lead to the formation of colloidal aggregates, whereas the utilization of equilibrium methods results in the formation of molecular solutions. The latter, however, have some unusual properties; new results considered in this review confirm previously expressed ideas about colloidal properties of these solutions. In “poor” (polar) solvents, lyophobic colloidal systems appear. Both “bottom-up” and “top-down” methods of preparation are well documented in the literature. However, N-methylpyrrolidine-2-one, DMSO, and DMF dissolve fullerenes quite easily and with less energy consumption. These solvents can be considered a subset of “poor” solvents that have some features of being “reactive” at the expense of basic properties. New data confirm that hydrosols of fullerenes are typical hydrophobic colloids that obey the Schulze–Hardy rule and other regularities in the presence of electrolytes. Organosols in acetonitrile and methanol are much less stable with respect to the effects of electrolytes. This allows us to assume a non-DLVO stabilizing factor in the hydrosols. Accordingly, a new estimate of the Hamaker constant of fullerene–fullerene interaction is proposed. In DMSO and DMF, the coagulation of fullerene sols is hindered due to strong solvation with these basic solvents.

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“…The aggregation processes and their dependence on the fullerene concentration [25][26][27][28][29] and the polarity of solvent mixtures [30][31][32][33][34][35][36] were intensively studied at that time. In particular, the origins of solvatochromic effects in the mixtures of solvents with fullerenes were determined [37,38], and the method of solvent exchange was invented [17,39]. It allowed aqueous liquid systems with fullerenes, but without a chemical modification of their surface, to be obtained.…”

Section: Properties Of Fullerene Solutions In the Mixtures Of Organicmentioning

confidence: 99%

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

Kyzyma

2020

Ukr. J. Phys.

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The unique properties of nanocarbon materials – in particular, fullerenes – has led in recent years to the expansion of the spectrum of their application in various fields of the industry, including the chemical, energy, and pharmaceutical ones. The use of fullerenes in new industries poses new challenges to the scientific and research community. Thus, new methods of obtaining biocompatible liquid systems with small-sized monodisperse fullerene aggregates are still being sought. The paper focuses on the properties of fullerene solutions in mixtures of organic solvents, which serve as a basis for the development of new methods for synthesizing the aqueous liquid systems with fullerenes.

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Development of Standard Reference Samples of Aqueous Fullerene Dispersions

Cited by 4 publications

References 93 publications

Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial

Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial

Colloid Chemistry of Fullerene Solutions: Aggregation and Coagulation

Liquid Systems with Fullerenes in Organic Solvents and Aqueous Media

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