Development of Spray Deposition/MALDI-TOFMS and Its Application to the Rapid Screening of Hydrolysis Products Derived from Nitrogen Mustards

Lin, Chu Feng; Liu, Ju Tsung; Lin, Cheng Huang

doi:10.2116/analsci.25.845

Cited by 10 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Impervious clothing must be worn and a full‐face particle respirator should ideally be used. The MALDI spots were prepared using the dried‐droplet method (1 μL of 10 μM peptide solution was mixed with 1 μL of the matrix solution and allowed to dry directly on the MALDI plate). Unless mentioned otherwise, the crystallization of each matrix was carried out under ambient conditions (20 °C).…”

Section: Methodsmentioning

confidence: 99%

Use of 1,5‐diaminonaphthalene to combine matrix‐assisted laser desorption/ionization in‐source decay fragmentation with hydrogen/deuterium exchange

Lemaire

Debois

Smargiasso

et al. 2013

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Use of 1,5‐diaminonaphthalene to combine matrix‐assisted laser desorption/ionization in‐source decay fragmentation with hydrogen/deuterium exchange

Lemaire

Debois

Smargiasso

et al. 2013

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…In recent years, matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) mass spectrometry (MS) has become important for military purposes as MALDI‐TOF MS was strongly endorsed and confirmed in the worldwide mass spectrometry community as a powerful and reliable tool for the detection of biological warfare agents and microorganisms with bio‐threat potential . For the detection or screening of chemical warfare nerve agents, gas chromatography and electrospray ionization (ESI)‐based mass spectrometry methods are more widely used than MALDI‐TOF mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

MALDI‐TOF Mass Spectrometric Analysis of Chemical Warfare Nerve Agent Simulants

Kim

Lee

Choi

et al. 2016

Bulletin Korean Chem Soc

View full text Add to dashboard Cite

To avoid possible danger, simulants of chemical warfare nerve gas agents, such as dimethyl methylphosphonate (DMMP), triethyl phosphate (TEP), di(propylene glycol) monomethyl ether (DPGMME), methyl salicylate, and diethyl phthalate (DEP), are often used for the development of a new detection and analysis method. In the present study, several MALDI matrices were evaluated to determine the optimal matrix for the simultaneous Matrix‐Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI‐TOF MS) detection of the above‐mentioned five chemical warfare agent (CWA) simulants, and α‐cyanohydroxycinnamic acid (CHCA) was found to be most effective in detecting all of the simulants without interference from strong background matrix peaks. Furthermore, the limits of detection for the five simulants were roughly estimated with the CHCA matrix. This information is expected to be important for the development of future electrowetting‐on‐dielectrics (EWOD)‐based sample preparation methods that can be subjected to subsequent analysis by MALDI‐TOF MS.

show abstract

“…MDEA, EDEA, and TEA have been determined in water samples . These NM degradation products have also been determined in other types of samples, such as in urine , blood , or soil . Generally, GC and LC have been used for the analysis of these samples.…”

Section: Introductionmentioning

confidence: 99%

Determination of nitrogen mustard degradation products in water samples using a portable capillary electrophoresis instrument

et al. 2013

View full text Add to dashboard Cite

In this work, a new purpose-made portable CE instrument with a contactless conductivity detector was used for the determination of degradation products of nitrogen mustards in different water samples. The capillary was coated with poly(1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate) to avoid analyte-wall interactions. The coating procedure was studied to obtain the best repeatability of the migration time of the analytes. Four different coating procedures were compared; flushing the capillary with the copolymer at 100 psi for 2 min at 60°C provided the best RSD values (<4%). The analytical method was also optimized. The use of 20 mM of MES adjusted to pH 6.0 with His as running buffer allowed a good baseline separation of the three analytes in different water samples without matrix interferences. The method permitted the detection of the three degradation products down to 5 μM.

show abstract

Development of Spray Deposition/MALDI-TOFMS and Its Application to the Rapid Screening of Hydrolysis Products Derived from Nitrogen Mustards

Cited by 10 publications

References 36 publications

Use of 1,5‐diaminonaphthalene to combine matrix‐assisted laser desorption/ionization in‐source decay fragmentation with hydrogen/deuterium exchange

Use of 1,5‐diaminonaphthalene to combine matrix‐assisted laser desorption/ionization in‐source decay fragmentation with hydrogen/deuterium exchange

MALDI‐TOF Mass Spectrometric Analysis of Chemical Warfare Nerve Agent Simulants

Determination of nitrogen mustard degradation products in water samples using a portable capillary electrophoresis instrument

Contact Info

Product

Resources

About