Development of spinal substrate for nociception

Rizvi, T.A.; Wadhwa, Shashi; Bijlani, Veena

doi:10.1016/0304-3959(87)91461-8

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“…Nociceptive signals are conducted via the afferent fibers to the spinal cord, where they are amplified or attenuated. Synapses between sensory fibers in the periphery and interneuron in the spinal cord begin to develop at approximately 13 weeks gestation and are completed by 30 weeks gestation (Rizvi, Wadhwa, & Bijlani, 1987). Noxious stimuli are conveyed via the axons that cross and ascend the spinal cord via the spinothalamic tract to the thalamus, hypothalamus, and cerebral cortex, where information about the impulse is processed (Anand & Hickey, 1987).…”

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confidence: 99%