Development of Solid self-emulsifying Drug Delivery Systems (SEDDS) to Improve the Solubility of Resveratrol

Aloisio, Carolina; Bueno, Maria Soledad; Ponte, Micaela Ponce; Paredes, Alejandro J.; Palma, Santiago Daniel; Longhi, Marcela Raquel

doi:10.4155/tde-2019-0054

Cited by 19 publications

(7 citation statements)

References 46 publications

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“…The release profile of the drug-loaded SEDDS was also successfully tuned and optimized to be released in a period of 1 h. Usually, lipid-based SEDDS have higher bioavailability which allows them to be nontoxic to the body. 93 5.6. Nanostructured Lipid Carriers.…”

Section: Lipid-based Ndds In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

183

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Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

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Section: Lipid-based Ndds In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

183

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“…Furthermore, SEDDs are also existing as liquid (L-SEDDs) and solid (S-SEDDs) formulations. The S-SEDDs are suggested to provide better stability, reproducibility, and patient compliance, in addition to ease of process control [36].…”

Section: Introductionmentioning

confidence: 99%

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

et al. 2020

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Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial infections. The drug is known to have low oral bioavailability (37%) which may be attributed to its relatively high molecular weight, low solubility, dissolution rate, and incomplete intestinal absorption. To overcome these drawbacks, liquid (L) and solid (S) self-emulsifying drug delivery systems (SEDDs) of AZM were developed and optimized. Eight different pseudo-ternary diagrams were constructed based on the drug solubility and the emulsification studies in various SEDDs excipients at different surfactant to co-surfactant (Smix) ratios. Droplet size (DS) < 150 nm, dispersity (Đ) ≤ 0.7, and transmittance (T)% > 85 in three diluents of distilled water (DW), 0.1 mM HCl, and simulated intestinal fluids (SIF) were considered as the selection criteria. The final formulations of L-SEDDs (L-F1(H)), and S-SEDDs (S-F1(H)) were able to meet the selection requirements. Both formulations were proven to be cytocompatible and able to open up the cellular epithelial tight junctions (TJ). The drug dissolution studies showed that after 5 min > 90% and 52.22% of the AZM was released from liquid and solid SEDDs formulations in DW, respectively, compared to 11.27% of the pure AZM, suggesting the developed SEDDs may enhance the oral delivery of the drug. The formulations were stable at refrigerator storage conditions.

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“…This can alter the duration of therapeutic activity and the bioavailability [ 100 ]. Stilbenoids can be delivered by different types of systems [ 101 ], namely, microspheres [ 102 ], microcapsules [ 103 ], self-emulsifying drug delivery system (SEDDS) [ 101 , 104 ], self-microemulsifying drug delivery system (SMEDDS) [ 105 , 106 , 107 ], nanosponges [ 108 ], nanoemulsions [ 109 , 110 ], self-nanoemulsifying drug delivery system (SNEDDS) [ 111 , 112 , 113 , 114 ], self-double-emulsifying drug delivery system (SDEDDS) [ 115 ], liposomes [ 116 , 117 ], nanoparticles [ 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 ], nanostructured lipid carriers [ 127 ], nanosuspensions [ 128 ], chitosan–gellan nanofiber [ 129 ], solidified phospholipid complex [ 130 ], spiral dextrin [ 131 ], and buccal cyclodextrin delivery system [ 132 ]. All delivery systems are extensively studied, but there is little clinical data.…”

Section: Enhancing the Bioavailability Of Stilbenoidsmentioning

confidence: 99%

Enhancing Bioavailability of Nutraceutically Used Resveratrol and Other Stilbenoids

2021

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Stilbenoids are interesting natural compounds with pleiotropic in vitro and in vivo activity. Their well-documented biological properties include anti-inflammatory effects, anticancer effects, effects on longevity, and many others. Therefore, they are nowadays commonly found in foods and dietary supplements, and used as a part of treatment strategy in various types of diseases. Bioactivity of stilbenoids strongly depends on different types of factors such as dosage, food composition, and synergistic effects with other plant secondary metabolites such as polyphenols or vitamins. In this review, we summarize the existing in vitro, in vivo, and clinical data from published studies addressing the optimization of bioavailability of stilbenoids. Stilbenoids face low bioavailability due to their chemical structure. This can be improved by the use of novel drug delivery systems or enhancers, which are discussed in this review. Current in vitro and in vivo evidence suggests that both approaches are very promising and increase the absorption of the original substance by several times. However, data from more clinical trials are required.

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Development of Solid self-emulsifying Drug Delivery Systems (SEDDS) to Improve the Solubility of Resveratrol

Cited by 19 publications

References 46 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

Enhancing Bioavailability of Nutraceutically Used Resveratrol and Other Stilbenoids

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