Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique

Negi, Jeetendra Singh; Chattopadhyay, Pronobesh; Sharma, Ashok; Ram, Veerma

doi:10.1016/j.ejps.2012.10.022

Cited by 89 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 ml nanoparticles dispersion was diluted up to 10 ml with distilled water to reduce opalescence during particle size measurement [27] . Beckman coulter Delsa Nano Common was also used for zeta potential measurement of nanoparticles.…”

Section: Chemical Test Identification For Gcvmentioning

confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

View full text Add to dashboard Cite

Kiroula, et al.: Glutathione-modified Gold Nanoparticles of GanciclovirThis article reports that ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. Citrate-reduced gold nanoparticles were prepared first from chloroauric acid. Further the surface of gold nanoparticles was modified with glutathione. Then ganciclovir was loaded onto the glutathione-modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. Drug loading of 87.27±2.52% was observed for ganciclovir-loaded gold nanoparticles. The particle size distribution of gold nanoparticles ranged from 26.3 to 31 nm. Thus ganciclovir-loaded gold nanoparticles were successfully prepared, which might further improve the oral bioavailability of ganciclovir.

show abstract

Section: Chemical Test Identification For Gcvmentioning

confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

View full text Add to dashboard Cite

show abstract

“…Formulation of poor orally bioavailable drug lopinavir into SLNs were reported using hot self nano-emulsification technique by Negi et al They demonstrated that the oral bioavailability of lopinavir was improved due to higher intestinal lymphatic uptake of lopinavir-loaded SLNs. 45 In another study, Silva et al formulated a risperidone (an atypical antipsychotic drug) into SLNs and investigated its longterm stability, biocompatibility and drug transport. They believed that the prepared drug delivery system has potential for the oral delivery of poorly water-soluble drugs like risperidone.…”

Section: Oral Administration Of Slnsmentioning

confidence: 99%

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Dolatabadi¹,

Valizadeh²,

Hamishehkar³

2015

Adv Pharm Bull

138

View full text Add to dashboard Cite

“…2 Low oral bioavailability of drug may be due to poor aqueous solubility, high first pass metabolism and efflux transport. 3 Lopinavir is a potent protease inhibitor used for the treatment of HIV infections, and it has become a leading component in combined chemotherapy commonly referred as Highly Active Anti-Retroviral Therapy (HAART). Lopinavir shows poor bioavailability when administered orally.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Solid Dispersion of Lopinavir by Using Different Techniques

Pekamwar¹,

Kankudte²,

Kale³

2015

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Poor aqueous solubility is the major drawback for the various types of drugs and many approaches have been introduced for the enhancement of solubility of such drugs. Solid dispersion is one of the technique adopted for the formulation of such drugs. The main objective of the present investigation was to improve the Solubility and dissolution rate of Lopinavir (LVR), a poorly water-soluble drug by solid dispersion technique using a water-soluble carrier, Soluplus. Among the various solid dispersion techniques Solvent Kneading Method used to prepare the solid dispersion in various ratios such as 1:0.5, 1:1 and 1:2. The differential scanning Calorimetry and x-ray diffraction studies demonstrated that enhanced solubility and dissolution rate from solid dispersion due to the decrease in the crystallinity. Solid dispersions were characterized for drug content, solubility study, dissolution behavior, XRD study, DSC study and SEM analysis. Finally Solid dispersion was formulated into conventional dosage form such as Tablet.

show abstract

Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique

Cited by 89 publications

References 28 publications

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Formulation and Evaluation of Solid Dispersion of Lopinavir by Using Different Techniques

Contact Info

Product

Resources

About