Development of smart hydrogels of etherified gum ghatti for sustained oral delivery of ropinirole hydrochloride

Ray, Somasree; Roy, Goutam; Maiti, Sabyasachi; Bhattacharyya, Uttam Kumar; Sil, Ayantika; Mitra, Ritwika

doi:10.1016/j.ijbiomac.2017.04.059

Cited by 18 publications

(4 citation statements)

References 38 publications

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“…This may allow regulation of drug delivery, stimulating fast release of the drug at early stages and decelerated release at later stages. 142 A smart hydrogel of etherified gum ghatti was recently developed by Ray et al 143 and successfully tested for controlled delivery of ropinirole hydrochloride, which is used to treat Parkinson’s disease.…”

Section: Non-food Applicationsmentioning

confidence: 99%

Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications

Singh,

Priya,

Kumar

et al. 2024

ACS Omega

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Gum ghatti, popularly known as Indian gum and obtained from Anogeissus latifolia, is a complex high-molecular-weight, water-soluble, and swellable nonstarch polysaccharide comprised of magnesium and calcium salts of ghattic acids and multiple monosugars. Unlike other nontimber forest produce, gums ghatti is a low-volume but high-value product. It has several applications and is widely used as food, in pharmaceuticals, and for wastewater treatment and hydrogel formation, and it has attracted a great deal of attention in the fields of energy, environmental science, and nanotechnology. Industrial applications of gum ghatti are primarily due to its excellent emulsification, stabilization, thickening, heat tolerance, pH stability, carrier, and biodegradable properties. However, utilization of gum ghatti is poorly explored and implemented due to a lack of knowledge of its production, processing, and properties. Nevertheless, there has been interest among investigators in recent times for exploring its production, processing, molecular skeleton, and functional properties. This present review focuses on production scenarios, processing aspects, structural and functional properties, and potential applications in the food, pharmaceuticals, nonfood, and other indigenous and industrial usages.

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Section: Non-food Applicationsmentioning

confidence: 99%

Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications

Singh,

Priya,

Kumar

et al. 2024

ACS Omega

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“…GG is widely employed in the food and pharmaceutical sectors due to its exceptional emulsifying abilities. It has recently gained popularity as a controlling agent in drug delivery applications [15,16]. In this work, we use a calcium-alginate/gum ghatti matrix and introduce multivalent cations (Mg 2+ , Ba 2+ , and Al 3+ ) to generate hetero-ionic SA-GG/MMT beads for controlled release of doxorubicin.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Ph-Responsive Polymeric Microbeads Intercalated With Montmorillonite for Controlled Release of Doxorubicin

RATHNAM,

REDDY,

PATWARI

2023

Int J App Pharm

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Objective: The aim of the present study is to develop pH-responsive polymeric microbeads for controlled release of doxorubicin. Methods: Doxorubicin-encapsulated polymeric microbeads were developed by a simple ionotropic gelation method using sodium alginate, gum ghatti, and montmorillonite (MMT). In this work, we investigate the positive benefits of MMT mineral as a drug carrier for the controlled release of DOX. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) were used to characterize the generated microbeads. The influence of hetero-ionic concentration on drug encapsulation efficiency and drug release from microbeads was examined. In vitro release and swelling studies were performed at pH 2.0 and 7.4 at 37 °C. The cytotoxicity of the developed microbeads was studied using in vitro cultures of the human breast cancer cell line (MCF-7). Results: FTIR confirms the generation of microbeads and also the interaction between the polymer matrix, DOX and MMT clay. XRD analysis reveals the molecular dispersion of DOX and the presence of MMT in the polymeric matrix. SEM studies reveal the developed microbeads are spherical in shape with rough surfaces. Swelling and in vitro release studies are dependent on the pH of the test medium, which may be favorable for intestinal drug delivery. MTT results reveal that the developed microbeads showed good in vitro toxicity against MCF-7 cells. The drug release kinetics of the generated microbeads are followed by both the higuchi and korsmeyer-peppas models. Conclusion: The findings suggest that the DOX-encapsulated microbeads are promising carriers for drug delivery applications. The fabricated microbeads further needs warrant for drug delivery applications.

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“…Gum Ghatti (GG) is an anionic polysaccharide obtained from the species Anogeissus latifolia, comprising of 1 →6 linked -Dgalactopyranose major units and alternating 4-O-subsituted and 2-O-subsituted-d-mannopyranose units along with a single larabinofuranose unit as side chain [21,22]. GG has widely used in food and pharmaceutical applications, due to its excellent emulsification property, many researchers have shown potential interest in the usage of GG in drug delivery applications as a controlling polymer [23]. Sodium alginate (SA) is a linear anionic polymer consisting of various amounts of 1 →4 linked β -D-guluronic acid and α-L-mannuronic acid residues.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Sodium Alginate/Gum Ghatti Ipn Microbeads Intercalated With Kaolin Nano Clay for Controlled Release of Curcumin

Ganesh

Suresh²,

Rao

2021

Int J App Pharm

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Objective: The objective of this study is to fabricate sodium alginate (SA)/gum ghatti (GG) microbeads intercalated with Kaolin (KA) nano clay for the sustained release of curcumin (CUR). Methods: The microbeads were prepared by a simple ionotropic gelation technique. The developed beads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Swelling studies and in vitro release studies were investigated under both pH 7.4 and pH 1.2 at 37 °C. Results: The developed microbeads were characterized by FTIR, which confirms the interaction between CUR, polymeric matrix and KA. DSC and XRD analysis reveals that the CUR has molecularly dispersed in the polymer matrix. In vitro results illustrated that microbeads were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The drug release mechanism was analyzed by fitting the release data into different kinetic equations and n values are obtained in the range of 0.609-0.640, suggesting that the developed microbeads showed the non-Fickian diffusion type drug release. Conclusion: These results clearly illustrated that the developed KA intercalated polymeric microbeads are potential drug carriers for the controlled release of CUR.

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Development of smart hydrogels of etherified gum ghatti for sustained oral delivery of ropinirole hydrochloride

Cited by 18 publications

References 38 publications

Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications

Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications

Development and Characterization of Ph-Responsive Polymeric Microbeads Intercalated With Montmorillonite for Controlled Release of Doxorubicin

Fabrication of Sodium Alginate/Gum Ghatti Ipn Microbeads Intercalated With Kaolin Nano Clay for Controlled Release of Curcumin

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