Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties

Galata, Evdokia; Georgakopoulou, Eleni A.; Kassalia, Maria-Emmanouela; Papadopoulou-Fermeli, Nefeli; Pavlatou, Evangelia A.

doi:10.3390/ma12162589

Cited by 28 publications

(49 citation statements)

References 84 publications

(137 reference statements)

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“…Moreover, the positive control ZnO NPs (25 µg/mL) also decreased the cell viability time-dependently. A recent study also reported that nitrogen-doped TiO 2 NPs inhibit the proliferation of malignant MDA-MB-231 breast cancer epithelial cells [ 39 ]. Based on cell viability results, we utilized the 25–100 µg/mL concentration range for further apoptosis and oxidative stress studies.…”

Section: Resultsmentioning

confidence: 99%

Barium Titanate (BaTiO3) Nanoparticles Exert Cytotoxicity through Oxidative Stress in Human Lung Carcinoma (A549) Cells

et al. 2020

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Barium titanate (BaTiO3) nanoparticles (BT NPs) have shown exceptional characteristics such as high dielectric constant and suitable ferro-, piezo-, and pyro-electric properties. Thus, BT NPs have shown potential to be applied in various fields including electro-optical devices and biomedicine. However, very limited knowledge is available on the interaction of BT NPs with human cells. This work was planned to study the interaction of BT NPs with human lung carcinoma (A549) cells. Results showed that BT NPs decreased cell viability in a dose- and time-dependent manner. Depletion of mitochondrial membrane potential and induction of caspase-3 and -9 enzyme activity were also observed following BT NP exposure. BT NPs further induced oxidative stress indicated by induction of pro-oxidants (reactive oxygen species and hydrogen peroxide) and reduction of antioxidants (glutathione and several antioxidant enzymes). Moreover, BT NP-induced cytotoxicity and oxidative stress were effectively abrogated by N-acetyl-cysteine (an ROS scavenger), suggesting that BT NP-induced cytotoxicity was mediated through oxidative stress. Intriguingly, the underlying mechanism of cytotoxicity of BT NPs was similar to the mode of action of ZnO NPs. At the end, we found that BT NPs did not affect the non-cancerous human lung fibroblasts (IMR-90). Altogether, BT NPs selectively induced cytotoxicity in A549 cells via oxidative stress. This work warrants further research on selective cytotoxicity mechanisms of BT NPs in different types of cancer cells and their normal counterparts.

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Section: Resultsmentioning

confidence: 99%

Barium Titanate (BaTiO3) Nanoparticles Exert Cytotoxicity through Oxidative Stress in Human Lung Carcinoma (A549) Cells

et al. 2020

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“…The mechanism provoking this selectivity remains an unclarified field for further investigation. The possible mediated mechanism, that leads to the inhibition of cell proliferation is possibly through ROS generation, since previous studies also suggested that TiO 2 NPs create a large amount of reactive oxygen species, that may potentially lead to DNA damage (5,(44)(45)(46). Various studies indicate that TiO 2 NPs might induce apoptotic cell death in human non-small cell lung cancer cells (47), in human colon carcinoma cells (48) and others (32,49,50).…”

Section: Discussionmentioning

confidence: 99%

“…TiO 2 can cause cytotoxicity (5) and induce apoptosis (6,7). Various studies indicate that TiO 2 nanoparticles (NPs) can interfere through EGFR signaling pathways (8), leading to the inhibition of cell proliferation and survival, inducing senescence or apoptosis.…”

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confidence: 99%

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Lаgopati

Kotsinas

Veroutis

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO 2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO 2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO 2 NPs) with anticancer potential. Materials and Methods: Ag/TiO 2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO 2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.Nanomedicine is an emerging inter-disciplinary scientific field that exploits the unique properties of innovative 425 This article is freely accessible online.

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“…where η is the percentage of degradation, A 0 is the chromatographic peak area of the initial memantine concentration before irradiation under UV light and A t is the concentration of memantine expressed as integrated area of chromatographic peak at sampling time t (min). The memantine degradation followed the first-order kinetics (Figure 9c), represented with the following equation [31,43,44]:…”

Section: Photocatalytic Degradation Of Memantine On Tio 2 -Coated Al mentioning

confidence: 99%

Titania-Coated Alumina Foam Photocatalyst for Memantine Degradation Derived by Replica Method and Sol-Gel Reaction

et al. 2020

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In the present work, alumina (Al2O3) foam was prepared by the replica method where a polyurethane (PU) foam (30 pores per inch (ppi)) template was impregnated with a 60 wt.% Al2O3 suspension. Sintered Al2O3 foam was used as substrate for the deposition of sol-gel derived titania (TiO2) film using dip coating. For the preparation of TiO2 sol, titanium(IV) isopropoxide (Ti-iPrOH) was used as the precursor. The common problem of qualification and quantification of a crystalline coating on a highly porous 3D substrate with an uneven surface was addressed using a combination of different structural characterization methods. Using Powder X-ray Diffraction (PXRD) and synchrotron Grazing Incidence X-ray Diffraction (GIXRD) on bulk and powdered Al2O3 foam and TiO2-coated Al2O3 foam samples, it was determined Al2O3 foam crystallizes to corundum and coating to anatase, which was also confirmed by Fourier Transformed Infrared Spectroscopy (FTIR). Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy (SEM/EDS) revealed the structural and microstructural properties of the substrate and coating. Differential Thermal Analysis (DTA) and Thermogravimetric Analysis (TGA) were used to clarify the evolution of the porous microstructure. The Al2O3-TiO2 composite was evaluated as a photocatalyst candidate for the degradation of the micropollutant medication memantine. The degradation rate was monitored using a light-emitting diode (LED) lamp operating at electromagnetic (EM) wavelength of 365 nm. The photocatalytic activity of sol-gel-derived TiO2 film immobilized on the Al2O3 foam was compared with commercially available TiO2 nanoparticles, P25-Degussa, in the form of a suspension. The levels of memantine were monitored by High-Performance Liquid Chromatography–Tandem Mass Spectrometry (HPLC–MS/MS). The efficiency and rate of the memantine photodegradation by suspended TiO2 nanoparticles is higher than the TiO2-coated Al2O3 foam. But, from the practical point of view, TiO2-coated Al2O3 foam is more appropriate as a valuable photocatalytic composite material.

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Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties

Cited by 28 publications

References 84 publications

Barium Titanate (BaTiO3) Nanoparticles Exert Cytotoxicity through Oxidative Stress in Human Lung Carcinoma (A549) Cells

Barium Titanate (BaTiO3) Nanoparticles Exert Cytotoxicity through Oxidative Stress in Human Lung Carcinoma (A549) Cells

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Titania-Coated Alumina Foam Photocatalyst for Memantine Degradation Derived by Replica Method and Sol-Gel Reaction

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