Development of SLN and NLC Enriched Hydrogels for Transdermal Delivery of Nitrendipine: In Vitro and In Vivo Characteristics

Bhaskar, K.; Chinnala, Krishna Mohan; Lingam, Meka; Mohan, Somagoni Jagan; Venkateswarlu, Vobalaboina; Rao, Yi; Anbu, J.; Ravichandran, V.

doi:10.1080/03639040802192822

Cited by 134 publications

(40 citation statements)

References 23 publications

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“…36 Bhaskar et al carried out the same research with Nitrendipene-loaded SLN and NLC dispersion incorporated into hydrogels. 25,37 They reported the same conclusion indicating the stability of nanoparticles in the point of size and PDI after 90 days of storage at room temperature. In the case of gelforming polymers with very polar groups like Chitosan, possible interactions between the negative surface charge of the lipid nanoparticles and the polar groups of this polymer must be considered as well.…”

Section: Introductionsupporting

confidence: 64%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

172

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Section: Introductionsupporting

confidence: 64%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

172

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“…Carbopol, is used due its compatibility with nanoparticulate dispersions, ease of preparation, esthetic appeal, thermal stability and optimum rheological properties while Miglyol 812 (a mixture of triglycerides), is chosen because the lipid composition of the epidermis is mainly based on triglycerides (25%) (47).The freshly prepared gel bases were subjected to determination for their rheological characteristics at 25°±1C. Rheograms are shown in Fig.…”

Section: Rheological Studiesmentioning

confidence: 99%

Formulation of a Novel Oxybenzone-Loaded Nanostructured Lipid Carriers (NLCs)

et al. 2010

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Abstract. The objective of the current study was to formulate oxybenzone into nanostructured lipid carriers (NLCs) to enhance its sunscreening efficacy and safety. NLCs of oxybenzone were prepared by the solvent diffusion method. A complete 2 3 factorial design was used for the evaluation of the prepared oxybenzone NLCs. The study design involves the investigation of the effect of three independent variables namely liquid lipid type (Miglyol 812 and oleic acid), liquid lipid concentration (15% and 30%), and oxybenzone concentration (5% and 10% with respect to total lipids) on the particle size (p.s.) , the entrapment efficiency (EE%) and the in vitro drug release after 8 h. The prepared NLCs were spherical in overall shape and were below 0.8 μm. Miglyol 812 and 30% liquid lipid were found to significantly decrease the p.s. and increase the EE% when compared to oleic acid and 15% liquid lipid. Increasing oxybenzone concentration increased significantly the p.s. but did not affect the EE%. NLCs prepared using Miglyol 812, 15% liquid lipid, and 10% oxybenzone showed slower drug release when compared to those prepared using oleic acid, 30% liquid lipid, and 5% oxybenzone, respectively. The candidate oxybenzone-loaded NLC dispersion was then formulated into gel. The incorporation of oxybenzone into NLCs greatly increased the in vitro sun protection factor and erythemal UVA protection factor of oxybenzone more than six-and eightfold, respectively, while providing the advantage of overcoming side effects of free oxybenzone as evidenced by very low irritation potential.

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“…An ethyl oleate-based microemul- 152 sion of aconitine was more effective in transdermal drug delivery 153 compared to glycerol dibehenate-based SLN which showed an 154 improved skin deposition [49]. However, LN as transdermal drug 155 carrier were described for tretinoin especially with the addition 156 of oleic acid [50], buprenorphine and its esters [51], and nitrendip- 157 ine [52]. The addition of permeation enhancers such as ethanol and 158 limonene to NLC with a low viscosity increased the permeation 159 rate of olanzapine and simvastatin [53].…”

Section: Introductionmentioning

confidence: 92%

“…If solid lipids are utilized the LN are specified as solid 52 lipid nanoparticles (SLN) [1], and if admixed liquid lipids are sup- 53 plemented they are defined as nanolipid carriers (NLC) [2]. Both 54 colloidal systems may increase the solubility and bioavailability 55 of active pharmaceutical ingredients (API), protect these com- 56 pounds from outer influences such as light or oxygen, and facilitate 57 drug targeting [3].…”

Section: Introductionmentioning

confidence: 99%

Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route

Lauterbach

Müller‐Goymann

2015

European Journal of Pharmaceutics and Biopharmaceutics

103

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Development of SLN and NLC Enriched Hydrogels for Transdermal Delivery of Nitrendipine: In Vitro and In Vivo Characteristics

Cited by 134 publications

References 23 publications

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Formulation of a Novel Oxybenzone-Loaded Nanostructured Lipid Carriers (NLCs)

Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route

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