Development of simvastatin electrospun fibers: a novel approach for sustained drug delivery

Betha, Sudheer; Reddy, B. Venkateswara; Varma, M. Mohan; Raju, D. Basava; Kolapalli, Venkata Ramana Murthy

doi:10.1007/s40005-014-0140-5

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…It was found that the drug release rate of NO.1 NFM was 19.80% within 1 h, and its cumulative release rate reached 84.76% at the 24th hour. In contrast, the cumulative drug release rate of SIM/polyethylene oxide NFM reached 98.86% within 12 h [ 30 ], which showed that as the carrier of SIM, the PCL/PEG hybrid phase was conducive to alleviating the phenomenon of initial burst release of drugs and achieving a longer-term sustained drug release. After adding SA/SIM, compared with those of NO.1 NFM, the cumulative drug release rates of NO.2 NFM at 1 and 24 h were reduced to 14.99% and 74.44%, respectively, and the initial burst release of drugs was significantly further alleviated.…”

Section: Resultsmentioning

confidence: 99%

“…Stearic acid (SA) is a kind of fatty acid widely existing in nature, which has good biocompatibility and is often used to prepare liposome biomaterials [ 30 ]. In this study, based on our previous work [ 31 ], SIM was first dissolved in SA solution, and then SA/SIM solution was dropped into the PCL/PEG spinning solution for electrospinning, which could make SIM disperse more evenly in the spinning solution, improve the compatibility between SIM and materials, and enhance the morphology and performance of nanofiber membranes (NFMs).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

Pan

Yang

2022

Molecules

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Simvastatin (SIM) particles are liposoluble drugs with large particle sizes, resulting in poor compatibility with electrospun polycaprolactone (PCL)/polyethylene glycol (PEG) nanofibers, so that part of them will be exposed to the electrospun nanofiber surface, which is easy to cause the burst release of drugs. Therefore, in this paper, stearic acid (SA) with good biocompatibility was innovatively added to increase the dispersion uniformity of SIM in the spinning solution, thus improving the performances of SIM-loaded PCL/PEG nanofiber membranes (NFMs). Accordingly, the effects of SA addition on the morphologies, mechanical properties, wettability, and drug release properties of the SIM-loaded NFMs were studied. The results showed that after SIM was dissolved in SA solution, the particle size of SIM was significantly reduced and could be evenly dispersed in the polymer spinning solution, thus obtaining the SIM-loaded composite NFMs with the best morphology and performance.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

Pan

Yang

2022

Molecules

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“…Reagent-grade acetone was used as an organic solvent. Curcumin-loaded PLGA microspheres were prepared using the electrospraying technique as reported previously, with slight modifications. , Briefly, 7.5 mg of curcumin and 140 mg of PLGA were dissolved in 2 mL of acetone. The solution was then loaded in a high-precision automatic syringe pump purchased from KD Scientific Inc. (Holliston, MA) with an adjustable flow rate and a stainless steel nozzle.…”

Section: Methodsmentioning

confidence: 99%

Hybrid Congregation of Islet Single Cells and Curcumin-Loaded Polymeric Microspheres as an Interventional Strategy to Overcome Apoptosis Associated with Pancreatic Islets Transplantation

Pathak

Regmi

Gupta

et al. 2016

ACS Appl. Mater. Interfaces

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Hypoxic or near-anoxic conditions that occur in the core of transplanted islets induce necrosis and apoptosis during the early stages after transplantation, primarily due to loss of vascularization during the isolation process. Moreover, secretion of various cytokines from pancreatic islets is detrimental to the viability of islet cells in vitro. In this study, we aimed to protect pancreatic islet cells against apoptosis by establishing a method for in situ delivery of curcumin to the pancreatic islets. Self-assembled heterospheroids composed of pancreatic islet cells and curcumin-loaded polymeric microspheres were prepared by the three-dimensional cell culture technique. Release of curcumin in the microenvironment of pancreatic islets promoted survival of the islets. In hypoxic culture conditions, which mimic the in vivo conditions after transplantation, viability of the islets was significantly improved, as indicated by a decreased expression of pro-apoptotic protein and an increased expression of anti-apoptotic protein. Additionally, oxidative stress-induced cell death was suppressed. Thus, unlike co-transplantation of pancreatic islets and free microspheres, which provided a wide distribution of microspheres throughout the transplanted area, the heterospheroid transplantation resulted in colocalization of pancreatic islet cells and microspheres, thereby exerting beneficial effects on the cells.

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Preparation and characterization of electrospun poly(ε‐caprolactone)–pluronic–poly(ε‐caprolactone)‐based polyurethane nanofibers

Xia

et al. 2016

J of Applied Polymer Sci

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In this study, amphiphilic poly(ε‐caprolactone)–pluronic–poly(ε‐caprolactone) (PCL–pluronic–PCL, PCFC) copolymers were synthesized by ring‐opening copolymerization and then reacted with isophorone diisocyanate to form polyurethane (PU) copolymers. The molecular weight of the PU copolymers was measured by gel permeation chromatography, and the chemical structure was analyzed by 1H‐nuclear magnetic resonance and Fourier transform infrared spectra. Then, the PU copolymers were processed into fibrous scaffolds by the electrospinning technology. The morphology, surface wettability, mechanical strength, and cytotoxicity of the obtained PU fibrous mats were investigated by scanning electron microscopy, water contact angle analysis, tensile test, and MTT analysis. The results show that the molecular weights of PCFC and PU copolymers significantly affected the physicochemical properties of electrospun PU nanofibers. Moreover, their good in vitro biocompatibility showed that the as‐prepared PU nanofibers have great potential for applications in tissue engineering. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43643.

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Development of simvastatin electrospun fibers: a novel approach for sustained drug delivery

Cited by 16 publications

References 25 publications

Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

Preparation and Characterization of Simvastatin-Loaded PCL/PEG Nanofiber Membranes for Drug Sustained Release

Hybrid Congregation of Islet Single Cells and Curcumin-Loaded Polymeric Microspheres as an Interventional Strategy to Overcome Apoptosis Associated with Pancreatic Islets Transplantation

Preparation and characterization of electrospun poly(ε‐caprolactone)–pluronic–poly(ε‐caprolactone)‐based polyurethane nanofibers

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