Development of simultaneous PET and Compton imaging using GAGG-SiPM based pixel detectors

Shimazoe, Kenji; Yoshino, Masao; Ohshima, Yusuke; Uenomachi, Mizuki; Oogane, Kenichiro; Orita, Tadashi; Takahashi, Hiroyuki; Kamada, Kei; Yoshikawa, Akira; Takahashi, Miwako

doi:10.1016/j.nima.2018.10.177

Cited by 58 publications

(45 citation statements)

References 10 publications

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“…[3] These performances meet the application requirements of nuclear medical imaging equipment, such as PET and SPECT. [4] The GAGG:Ce crystal belongs to the A 3 B 2 C 3 O 12 garnet structure. It was obtained under the guidance of "bandgap engineering;" Ga partially replaces the Al in the Gd 3 Al 5 O 12 (GAG).…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals

Meng

Chen

et al. 2021

Physica Status Solidi (b)

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Large-sized Gd 3 Al 2.3 Ga 2.7 O 12 :Ce single crystals are grown by the Czochralski method. The distribution of Al and Ga at octahedral (oct-, 6-oxygen-coordinated) and tetrahedral (tet-, 4-oxygen-coordinated) sites in the crystal is studied. Rietveld refinement is used to analyze the site occupation of Al and Ga. The results show that Ga ions with a larger radius than Al ions prefer to occupy the more compact tetrahedral sites. Density functional theory calculations show that the energy for a Ga ion at the tetrahedral site is lower than that at the octahedral site in the Gd 3 Al 5 O 12 crystal, whereas the case for Al occupation in the Gd 3 Ga 5 O 12 crystal is opposite. Slater rules are used to estimate the effective charge number of different ions, and the distribution of coordination ions around the octahedral and tetrahedral sites is analyzed. Then, the interaction between ions is simplified and the repulsive energy between Al/Ga and the coordination ions is calculated, which could provide reasonable understanding on the abnormal occupation. In addition, the occupation of Sc in Gd/Y garnet systems is also discussed using this method.

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Section: Introductionmentioning

confidence: 99%

“…[ 3 ] These performances meet the application requirements of nuclear medical imaging equipment, such as PET and SPECT. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals

Meng

Chen

et al. 2021

Physica Status Solidi (b)

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“…Compton cameras have several advantages in nuclear medicine and are consequently expected to be utilized as a new medical instrument for various tasks. In particular, Compton cameras can simultaneously image multi-tracers, including single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) tracers [5][6][7][8][9][10]. Simultaneous imaging has the potential for clinical and molecular application in many areas [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Sakai

Parajuli

Kubota

et al. 2020

Sensors

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Compton cameras can simultaneously detect multi-isotopes; however, when simultaneous imaging is performed, crosstalk artifacts appear on the images obtained using a low-energy window. In conventional single-photon emission computed tomography, a dual energy window (DEW) subtraction method is used to reduce crosstalk. This study aimed to evaluate the effectiveness of employing the DEW technique to reduce crosstalk artifacts in Compton images obtained using low-energy windows. To this end, in this study, we compared reconstructed images obtained using either a photo-peak window or a scatter window by performing image subtraction based on the differences between the two images. Simulation calculations were performed to obtain the list data for the Compton camera using a 171 and a 511 keV point source. In the images reconstructed using these data, crosstalk artifacts were clearly observed in the images obtained using a 171 keV photo-peak energy window. In the images obtained using a scatter window (176–186 keV), only crosstalk artifacts were visible. The DEW method could eliminate the influence of high-energy sources on the images obtained with a photo-peak window, thereby improving quantitative capability. This was also observed when the DEW method was used on experimentally obtained images.

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“…The properties of GaGG crystals of various form factors and from various producers, coupled to different light collection devices, are being actively investigated, since this scintillator might prove advantageous for imaging devices where a high energy resolution is needed, such as medical imaging devices in PET. GaGG may be especially interesting for improving the detection capabilities of Compton imaging systems, which use Compton scattering kinematics to determine the direction of incoming gamma radiation [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Investigation of GaGG:Ce with TOFPET2 ASIC Readout for Applications in Gamma Imaging Systems

et al. 2020

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We investigated two detector modules, each consisting of a 8 × 8 matrix of GaGG:Ce crystals with a crystal size of 3 × 3 × 20 mm3 and a 3.2 mm pitch. The light is collected by a 8 × 8 silicon photomultiplier array, with one silicon photomultiplier matching one crystal. The signals are read out and processed using the TOFPET2 ASIC. Performed laboratory tests of the detectors were performed using a 22Na source, where energy and coincidence time resolution with different optical coupling were examined between the crystals and silicon photomultipliers, as well as under various operating voltages. The mean energy resolution of 9.8±0.6% at 511 keV was observed and it was shown that the coincidence time resolution of 384±33 ps could be achieved. The results reassure that the GaGG scintillator is a very promising candidate for the development of imaging systems, in particular, ones utilizing Compton scattering where the energy resolution plays a critical role and a moderate timing performance is acceptable.

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Development of simultaneous PET and Compton imaging using GAGG-SiPM based pixel detectors

Cited by 58 publications

References 10 publications

Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals

Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Investigation of GaGG:Ce with TOFPET2 ASIC Readout for Applications in Gamma Imaging Systems

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Development of simultaneous PET and Compton imaging using GAGG-SiPM based pixel detectors

Cited by 58 publications

References 10 publications

Abnormal Site Preference of Al and Ga in Gd3Al2.3Ga2.7O12:Ce Crystals

Abnormal Site Preference of Al and Ga in Gd3Al2.3Ga2.7O12:Ce Crystals

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Investigation of GaGG:Ce with TOFPET2 ASIC Readout for Applications in Gamma Imaging Systems

Contact Info

Product

Resources

About

Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals

Abnormal Site Preference of Al and Ga in Gd₃Al_2.3Ga_2.7O₁₂:Ce Crystals