OPCAB was performed before the advent of heart lung machine. But with the development of stabilizers, coronary artery bypass grafting has been performed over the last two decades successfully in many centres around the world. But still 80% of bypass surgeries are done on the heart lung machine. We were one of the few teams who have been performing this OPCAB for the past 18 years. All along, we have been innovating, fabricating and developing and patenting instruments, techniques and technology to help us perform OPCAB in 100% of all our coronary patients. That too being able to reduce the mortality of bypass surgery to less than 0.5%. In this chapter, we have attempted to write down our strategy, in order to successfully perform OPCAB in all our patients, so that the coming generation can benefit from it.