Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Shao, Wei; Liu, Hui; Liu, Xiufeng; Wang, Shuxia; Wu, Jimin; Zhang, Rui; Min, Huihua; Huang, Min

doi:10.1016/j.carbpol.2015.06.057

Cited by 144 publications

(73 citation statements)

References 41 publications

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“…SAEW and AEW containing ACC and high ORP effectively inactivate food-borne pathogens. However, the underlying mechanisms of inactivation remain unknown [19]. It is still not clear whether the antimicrobial potential is due to ORP, chlorine compounds, pH, or the combination of these factors [30].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, alginate can be used in the manufacture of soft capsules and consumed as a beverage to lower blood sugar levels [18]. The use of sodium alginate or composite matrix with sodium alginate as an antibacterial material has been previously studied [19,20,21]. Because of its low toxicity, as well as its biocompatibility and biodegradability properties, sodium alginate is often applied when preparing biomedical materials, (e.g., wound dressing materials with antibacterial activity) [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…The use of sodium alginate or composite matrix with sodium alginate as an antibacterial material has been previously studied [19,20,21]. Because of its low toxicity, as well as its biocompatibility and biodegradability properties, sodium alginate is often applied when preparing biomedical materials, (e.g., wound dressing materials with antibacterial activity) [18,19]. In our previous paper [15], the presence of ACC in sodium alginate hydrosol treated with DC was observed.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Król

Marycz

Kulig

et al. 2017

IJMS

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The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction potential (ORP), electrical conductivity (EC), and available chlorine concentration (ACC) were measured. The effect of sodium alginate hydrosols treated with DC on Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Micrococcus luteus, Escherichia coli, Salmonella enteritidis, Yersinia enterocolitica, Pseudomonas fluorescence, and RAW 264.7 and L929 cells was investigated. Subsequently, the antioxidant properties of hydrosols were evaluated by determining the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH) and ferric reducing antioxidant power (FRAP). The results have shown that after applying 400 mA in hydrosol samples with 0.1% and 0.2% NaCl all tested bacteria were inactivated. The ACC concentration of C400 samples with NaCl was equal to 13.95 and 19.71 mg/L, respectively. The cytotoxicity analysis revealed that optimized electric field conditions and the addition of sodium chloride allow for the avoidance of toxicity effects on normal cells without disturbing the antibacterial effects. Due to the presence of oxidizing substances, the DPPH of variants treated with DC was lower than the DPPH of control samples.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Król

Marycz

Kulig

et al. 2017

IJMS

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“…Application: wound dressings and skin tissue engineering Alginate/BC/Silver sulfadiazine [96] The composite has an excellent antibacterial activities & good biocompatibility. Application: wound dressings Alginate/CMC/Silver sulfadiazine [97] The film exhibits better swelling time.…”

Section: Preparation Of Seaweed/cellulose Blendsmentioning

confidence: 99%

Biodegradable polymer films from seaweed polysaccharides: A review on cellulose as a reinforcement material

Khalil¹,

Tye²,

Saurabh³

et al. 2017

Express Polym. Lett.

181

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“…Thus, the development of innovative wound and burn dressing advancement is in great demand [12,13] known that the silver and its compounds such as silver sulfadiazine (AgSD) are widely used in most of the skin complications because of their peerless antimicrobial activity [14,15]. But, the AgSD shows cytotoxicity and allergic reactions in clinical studies, which lead to hamper the healing progress of skin [16]. Therefore, a substitute scenario is required to improve drug (AgSD) efficacy.…”

Section: Introductionmentioning

confidence: 99%

Improved antimicrobial property and controlled drug release kinetics of silver sulfadiazine loaded ordered mesoporous silica

Jangra

Devi²,

Tomer

et al. 2016

Journal of Asian Ceramic Societies

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a b s t r a c tThe present study deals with the loading of silver sulfadiazine into ordered mesoporous silica material by post-impregnation method and its effect on the in vitro release kinetics and antimicrobial property of the drug. The formulated SBA-15 silica material with rope-like morphology and SBA-15-silver sulfadiazine (SBA-AgSD) were characterized by UV-visible spectrophotometer, small and wide-angle powder X-ray diffraction (PXRD), field emission scanning electron microscope (FESEM) and high resolution transmission electron microscope (HRTEM). Thermo-gravimetric analysis of SBA-AgSD revealed a high loading amount of 52.87%. Nitrogen adsorption-desorption analysis confirmed the drug entrapment into host material by revealing a reduced surface area (214 m 2 /g) and pore diameter (6.7 nm) of the SBA-AgSD. The controlled release of silver sulfadiazine drug from the mesoporous silica to simulated gastric, intestinal and body fluids was evaluated. The Korsmeyer-Peppas model fits the drug release data with the non-Fickian diffusion model and zero order kinetics of SBA-AgSD. The antibacterial performance of the SBA-AgSD was evaluated with respect to Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa. The controlled drug delivery of the SBA-AgSD revealed improved antibacterial activity, thus endorsing its applicability in effective wound dressing.

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Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property

Cited by 144 publications

References 41 publications

Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Biodegradable polymer films from seaweed polysaccharides: A review on cellulose as a reinforcement material

Improved antimicrobial property and controlled drug release kinetics of silver sulfadiazine loaded ordered mesoporous silica

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