Development of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds for use as wound dressings

Pankongadisak, Porntipa; Ruktanonchai, Uracha; Supaphol, Pitt; Suwantong, Orawan

doi:10.1002/pi.4787

Cited by 36 publications

(23 citation statements)

References 46 publications

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“…From these results, it might be concluded that the size of embedded beads affected the compressive modulus of the scaffold. The smaller sizes of the embedded beads and the higher compressive modulus of the scaffolds were obtained according to the structural reinforcement principle …”

Section: Resultssupporting

confidence: 88%

“…From the previous study, Pankongadisak et al prepared the neat and nAg‐containing CaAlg beads with the diameter range between ~140 and ~149 µm . Thus, the emulsification/external gelation method was employed in this study to prepare smaller diameters of the neat and nAg‐containing CaAlg beads.…”

Section: Resultsmentioning

confidence: 99%

“…Shown in eqn is the calculation of the percent reduction of bacteria ( R , %):

R (() %) = \frac{100 ((), B - A)}{B}

where A is the number of bacteria removed from the nAg‐containing CaAlg beads embedded in gelatin scaffolds and B is the number of bacteria removed from the neat CaAlg beads embedded in gelatin scaffolds after incubation at 37°C for 24 hr.…”

Section: Methodsmentioning

confidence: 99%

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Gelatin scaffolds functionalized by silver nanoparticle-containing calcium alginate beads for wound care applications

Pankongadisak

Ruktanonchai

Supaphol

et al. 2016

Polym. Adv. Technol.

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The embedding of silver nanoparticle (nAg)‐containing calcium alginate (CaAlg) beads in gelatin scaffolds was aimed to reduce the burst release and prolong the release of silver (Ag+) ions for a long period of time. The reduced sizes of the nAg‐containing CaAlg beads were prepared by an emulsification/external gelation method. The diameter of these beads was ~2 µm. The nAg‐containing CaAlg beads were then embedded into gelatin scaffolds by a freeze‐drying method for evaluating the potential of these scaffolds as wound dressings. The compressive modulus of these scaffolds embedded with nAg‐containing CaAlg beads ranged between 7 and 9 kPa. For release study, the cumulative released amounts of Ag+ ions from the nAg‐containing CaAlg beads embedded in gelatin scaffolds were lower than those from the nAg‐containing CaAlg beads. Moreover, the nAg‐containing CaAlg beads embedded in gelatin scaffolds had great antibacterial activity and low cytotoxicity. Thus, these scaffolds had potential for sustaining the release and use in wound care applications, especially chronic wound. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

“…Shown in eqn is the calculation of the percent reduction of bacteria ( R , %):

R (() %) = \frac{100 ((), B - A)}{B}

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Gelatin scaffolds functionalized by silver nanoparticle-containing calcium alginate beads for wound care applications

Pankongadisak

Ruktanonchai

Supaphol

et al. 2016

Polym. Adv. Technol.

Self Cite

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“…We found 11 studies using silver-impregnated dressings that evaluated wound odor, in 10 it was a secondary outcome,1,7,33,51,53–55,57–59,60 and it was the primary outcome in one clinical case series where silver was used along with activated charcoal 126. The authors reported a reduction in wound malodor and an increase of tissue granulation.…”

Section: Efficacy Of Various Treatments On Wound Odormentioning

confidence: 99%

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

Akhmetova

Saliev

Allan

et al. 2016

Journal of Wound, Ostomy &Amp; Continence Nursing

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The process of wound healing is often accompanied by bacterial infection or critical colonization, resulting in protracted inflammation, delayed reepithelization, and production of pungent odors. The malodor produced by these wounds may lower health-related quality of life and produce psychological discomfort and social isolation. Current management focuses on reducing bacterial activity within the wound site and absorbing malodorous gases. For example, charcoal-based materials have been incorporated into dressing for direct adsorption of the responsible gases. In addition, multiple topical agents, including silver, iodine, honey, sugar, and essential oils, have been suggested for incorporation into dressings in an attempt to control the underlying bacterial infection. This review describes options for controlling malodor in chronic wounds, the benefits and drawbacks of each topical agent, and their mode of action. We also discuss the use of subjective odor evaluation techniques to assess the efficacy of odor-controlling therapies. The perspectives of employing novel biomaterials and technologies for wound odor management are also presented.

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“…[49][50][51][52] Silver-based wound care dressings contain nano-sized silver particles that signifi cantly enlarge the surface area of the silver and enhance its antimicrobial actions when compared to bulk silver metal. 57 Charged nanoparticles adhere to the bacterial cell wall impairing function of key proteins and enzymes.…”

Section: Silvermentioning

confidence: 99%

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

2016

Journal of Wound, Ostomy &Amp; Continence Nursing

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Development of silver nanoparticles-loaded calcium alginate beads embedded in gelatin scaffolds for use as wound dressings

Abstract: Silver nanoparticles (AgNPs)‐loaded calcium alginate beads embedded in gelatin scaffolds were developed to sustain and maintain the release of silver (Ag+) ions over an extended time period.

Cited by 36 publications

References 46 publications

Gelatin scaffolds functionalized by silver nanoparticle-containing calcium alginate beads for wound care applications

Gelatin scaffolds functionalized by silver nanoparticle-containing calcium alginate beads for wound care applications

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

A Comprehensive Review of Topical Odor-Controlling Treatment Options for Chronic Wounds

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