Development of Silica-Coated Silver Iodide Nanoparticles and Their Biodistribution

Sakurai, Yasuki; Tada, Hiroshi; Gonda, Kohsuke; Takeda, Motohiro; Cong, Liman; Amari, Masakazu; Kobayashi, Yoshio; Watanabe, Mika; Ishida, Toru; Ohuchi, Noriaki

doi:10.1620/tjem.228.317

Cited by 11 publications

(11 citation statements)

References 20 publications

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“…Imaging experiments can be performed in parallel to analytical experiments, as to add details to the NSC toxicity and pharmacokinetic profile (Huang et al, 2011;Xie et al, 2011). For instance, Sakurai et al (2012) reported the localization of Ag NSCs in hepatocytes, solenocytes and kidney parenchyma by analysis of tissue samples collected concurrently using inductively coupled plasma mass spectrometry and transmission electron microscopy. Meanwhile, conventional histological image analysis carried out in parallel to analytical experiments helped to reveal the pharmacodynamic consequences of NSC treatment, including tissue damage, inflammation, lesions and vacuole formation (Ispas et al, 2009).…”

Section: In Vivo Modelsmentioning

confidence: 99%

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

Cheah

Kiew

Lee

et al. 2017

J of Applied Toxicology

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While nano-sized construct (NSC) use in medicine has grown significantly in recent years, reported unwanted side effects have raised safety concerns. However, the toxicity of NSCs to the cardiovascular system (CVS) and the relative merits of the associated evaluation methods have not been thoroughly studied. This review discusses the toxicological profiles of selected NSCs and provides an overview of the assessment methods, including in silico, in vitro, ex vivo and in vivo models and how they are related to CVS toxicity. We conclude the review by outlining the merits of telemetry coupled with spectral analysis, baroreceptor reflex sensitivity analysis and echocardiography as an appropriate integrated strategy for the assessment of the acute and chronic impact of NSCs on the CVS.

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Section: In Vivo Modelsmentioning

confidence: 99%

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

Cheah

Kiew

Lee

et al. 2017

J of Applied Toxicology

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“…Accordingly, methods with no use of amines are required as methods for producing the silica-coated particles. From this view point, our previous works proposed methods using sodium hydroxide (NaOH) not amine for preparing various silica-coated particles (Ayame et al, 2011;Kobayashi et al, 2010cKobayashi et al, , 2011Kobayashi et al, , 2012aKobayashi et al, , 2012bKobayashi et al, , 2012cKobayashi et al, , 2013aKobayashi et al, , 2013bMorimoto et al, 2011;Sakurai et al, 2012). Our group has targeted AgI nanoparticles for silica-coating, since their colloid solution is easily prepared in aqueous solution.…”

Section: Silica-coated Agi Particlesmentioning

confidence: 99%

“…Our group has targeted AgI nanoparticles for silica-coating, since their colloid solution is easily prepared in aqueous solution. Thus, this section introduces an amine catalyst-free method for silica-coating of AgI nanoparticles (AgI/SiO 2 ) (Ayame et al, 2011;Kobayashi et al, 2012aKobayashi et al, , 2012cSakurai et al, 2012). A study on X-ray imaging properties of the AgI/SiO 2 particles colloid solution is also introduced (Ayame et al, 2011;Kobayashi et al, 2012a).…”

Section: Silica-coated Agi Particlesmentioning

confidence: 99%

Imaging Processes Using Core-Shell Particle Colloid Solutions for Medical Diagnosis

Kobayashi¹,

Gonda²,

Ohuchi³

2014

AJS

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This paper describes our studies on development of methods for preparing colloid solutions of core-shell particles composed of core of materials with imaging ability and shell of silica that is inert to living bodies, and on their imaging properties. The methods for silica-coating are based on hydrolysis and condensation of silicone alkoxide in the presence of particles. AgI nanoparticles fabricated by mixing AgClO 4 aqueous solution with KI aqueous solution were silica-coated with an aid of silane coupling agent. The silica-coated AgI particle colloid solution revealed X-ray imaging ability. Au nanoparticles, which were produced with reduction of HAuCl 4 using citrate as reducing reagent and then surface-modified with silane coupling agent, were coated with silica. Images of the colloid solution were successfully taken through X-ray irradiation. For Gd compound, silica nanoparticles fabricated by a Stöber method were coated with Gd compound shell by a homogeneous precipitation method, and then coated with silica shell. The colloid solution was successfully imaged through magnetic resonance. Commerciallyavailable Cd-related semiconductor nanoparticles were surfacemodified with silane coupling agent, and then coated with silica. Tissues of mouse were imaged by injecting their colloid solution and using an in vivo fluorescence imaging system (IVIS).

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“…[15,16] One of these is polymer-coated bismuth sulfide (Bi 2 S 3 ). Bi 2 S 3 shows higher X-ray absorption than iodine.…”

Section: Introductionmentioning

confidence: 99%

X-ray computed tomography imaging of a tumor with high sensitivity using gold nanoparticles conjugated to a cancer-specific antibody via polyethylene glycol chains on their surface

Nakagawa

Gonda

Kamei

et al. 2016

Science and Technology of Advanced Materials

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Contrast agents are often used to enhance the contrast of X-ray computed tomography (CT) imaging of tumors to improve diagnostic accuracy. However, because the iodine-based contrast agents currently used in hospitals are of low molecular weight, the agent is rapidly excreted from the kidney or moves to extravascular tissues through the capillary vessels, depending on its concentration gradient. This leads to nonspecific enhancement of contrast images for tissues. Here, we created gold (Au) nanoparticles as a new contrast agent to specifically image tumors with CT using an enhanced permeability and retention (EPR) effect. Au has a higher X-ray absorption coefficient than does iodine. Au nanoparticles were supported with polyethylene glycol (PEG) chains on their surface to increase the blood retention and were conjugated with a cancer-specific antibody via terminal PEG chains. The developed Au nanoparticles were injected into tumor-bearing mice, and the distribution of Au was examined with CT imaging, transmission electron microscopy, and elemental analysis using inductively coupled plasma optical emission spectrometry. The results show that specific localization of the developed Au nanoparticles in the tumor is affected by a slight difference in particle size and enhanced by the conjugation of a specific antibody against the tumor.

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Development of Silica-Coated Silver Iodide Nanoparticles and Their Biodistribution

Cited by 11 publications

References 20 publications

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

Imaging Processes Using Core-Shell Particle Colloid Solutions for Medical Diagnosis

X-ray computed tomography imaging of a tumor with high sensitivity using gold nanoparticles conjugated to a cancer-specific antibody via polyethylene glycol chains on their surface

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