Development of self-oscillating polymers and gels with autonomous function

Yoshida, Ryo

doi:10.1038/pj.2010.75

Cited by 25 publications

(14 citation statements)

References 47 publications

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“…Since the first report in 1996, [7] we have been systematically studying polymer and gel systems as novel biomimetic materials. [8][9][10][11][12][13][14][15] The design of polymers for biomedical applications has also been investigated.…”

Section: Introductionmentioning

confidence: 99%

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

Murase¹,

Takeshima²,

Yoshida³

2011

Macromolecular Bioscience

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A "self-oscillating" gel that swells and deswells periodically under constant conditions is developed as a novel biomimetic gel differing from conventional stimuli-responsive polymer gels. By utilizing the peristaltic motion of the self-oscillating gel, autonomous mass-transport systems can be realized. With the propagation of the chemical wave, the loaded gel cargo is autonomously transported by rotating on the surface. To apply the self-driven gel conveyer to a wider range of uses, it is important to investigate the influence of the physical interaction between the self-oscillating gel and the loaded cargo on its transporting ability. Here, the effect of the interaction is evaluated by using several kinds of gel cargo with varying charge states, hydrophilicities, and surface roughnesses.

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Section: Introductionmentioning

confidence: 99%

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

Murase¹,

Takeshima²,

Yoshida³

2011

Macromolecular Bioscience

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“…Example of this is the characterization of the long-term reversibility and hysteresis of externally triggered [61][62] and self-oscillating materials. 63 …”

Section: Discussionmentioning

confidence: 99%

In situ characterization of structural dynamics in swelling hydrogels

et al. 2016

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Characterizing the structural morphology and the local viscoelastic properties of soft complex systems raises significant challenges. Here we introduce a dynamic light scattering method capable of in situ, continuous monitoring of structural changes in evolving systems such as swelling gels. We show that the inherently non-stationary dynamics of embedded probes can be followed using partially coherent radiation, which effectively isolates only single scattering contributions even during the dramatic changes in the scattering regime. Using a simple and robust experimental setup, we demonstrate the ability to continuously monitor the structural dynamics of chitosan hydrogels formed by the Ag(+) ion-triggered gelation during their long-term swelling process. We demonstrate that both the local viscoelastic properties of the suspending medium and an effective cage size experienced by diffusing probe particles loaded into the hydrogel can be recovered and used to describe the structural dynamics of hydrogels with different levels of cross-linking. This characterization capability is critical for defining and controlling the hydrogel performance in different biomedical applications.

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“…For example, the spontaneous changes with temporal periodicity, such as cell cycles, biorhythms, heartbeat, brain waves, and hormones secretion, are described as living system autonomous oscillation. Inspired by this, Belousov-Zhabotinsky (BZ) reaction was applied to prepare a novel biomimetic polymer nanogel that autonomously oscillates without an external control or switch [102]. In another study, following the same BZ reaction, surfactant-free precipitation polymerization method was employed to fabricate submicron-sized self-oscillating microgel beads based on thermosensitive poly-N-isopropylacrylamide (pNIPAm) macromer [103] that could expediently be applied as bioactuators.…”

Section: Biomedical Polymeric Nanogelmentioning

confidence: 99%

Perspectives on the Emerging Applications of Multifaceted Biomedical Polymeric Nanomaterials

Gumel

Annuar

Yusuf

2015

Journal of Nanomaterials

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Biodegradable and biocompatible polymeric nanomaterials, serving as biomedical devices have garnered significant attention as a promising solution to therapeutic management of many chronic diseases. Despite their potentials, majority of the synthetic nanomaterials used in biomedical applications lack crucial properties, for example, ligand binding sites, responsiveness, and switchability to efficiently deliver intended drugs to the target site. Advancements in manipulating nanoscale geometry have incurred the incorporation of triggered release mechanism within the nanomaterials design. This expanded their potential applications beyond nanocarriers to theranostics exhibiting both tandem drug delivery and diagnostic capabilities. Additionally, it highlights possibilities to design nanomaterials that could translate chemical response(s) to photometric display, thus making affordable biosensors and actuators readily available for biomedical exploitation. It is anticipated that, in the near future, these implementations could be made to access some of the most difficult therapy locations, for example, blood brain barrier to provide efficient management of Alzheimer, Huntington, and other neurodegenerative diseases. This review aims to serve as a reference platform by providing the readers with the overview of the recent advancements and cutting-edge techniques employed in the production and instrumentation of such nanomaterials.

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Development of self-oscillating polymers and gels with autonomous function

Cited by 25 publications

References 47 publications

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

In situ characterization of structural dynamics in swelling hydrogels

Perspectives on the Emerging Applications of Multifaceted Biomedical Polymeric Nanomaterials

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