Development of Responsive Lanthanide-Based Magnetic Resonance Imaging and Luminescent Probes for Biological Applications

Hanaoka, Kenjiro

doi:10.1248/cpb.58.1283

Cited by 39 publications

(36 citation statements)

References 94 publications

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“…In addition, given that fluorescence imaging is difficult at more than a few millimetres in depth within a tissue specimen and MRI has low selectivity and sensitivity, dualmodality (combined MRI/fluorescence) imaging can provide more information on targeted molecules than a single imaging modality and is useful for biomedical research and clinical practice. 242 On the basis of the advantages of the fluorometric, MRI, and colorimetric methods and these existing challenges, we hope further investigation and development of sensors for the first-row d-block metal ions will be carried out. …”

Section: Discussionmentioning

confidence: 99%

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

et al. 2015

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Transition metals (d-blocks) are recognized as playing critical roles in biology, and they most often act as cofactors in diverse enzymes; however, improper regulation of transition metal stores is also connected to serious disorders. Therefore, the monitoring and imaging of transition metals are significant for biological research as well as clinical diagnosis. In this article, efforts have been made to review the chemical sensors that have been developed for the detection of the first-row d-block metals (except Cu and Zn): Cr, Mn, Fe, Co, and Ni. We focus on the development of fluorescent sensors (fall into three classes: "turn-off", "turn-on", and ratiometric), colorimetric sensors, and responsive MRI contrast agents for these transition metals (242 references). Future work will be likely to fill in the blanks: (1) sensors for Sc, Ti, and V; (2) MRI sensors for Cr, Mn, Co, Ni; (3) ratiometric fluorescent sensors for Cr(6+), Mn(2+), and Ni(2+), explore new ways of sensing Fe(3+) or Cr(3+) without the proton interference, as well as extend applications of MRI sensors to living systems.

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Section: Discussionmentioning

confidence: 99%

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

et al. 2015

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“…MRI with ECF CAs is typically used for a whole body scan, and is not capable of sensing biochemical activities. During the last decade, new types of CAs have been developed—targeted CAs that accumulate in specific tissues and organs and allow for an improved diagnosis of these body regions,41,42,79,82,83 as well as activatable CAs whose relaxivity reports about a specific parameter of the microenvironment in which they distribute and allow for MRI to indicate biological processes 10,27,35,36,41,49,64,67,68,75. Most, though not all, activatable CAs reported are typically small molecular Gd chelates.…”

Section: Introductionmentioning

confidence: 99%

Activatable T 1 and T 2 Magnetic Resonance Imaging Contrast Agents

Osborne

Louie

2011

Ann Biomed Eng

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Magnetic resonance imaging (MRI) has become one of the most important diagnosis tools available in medicine. Typically MRI is not capable of sensing biochemical activities. However, recently emerged activatable MRI contrast agents (CAs), whose relaxivity is variable in response to a specific parameter change in the surrounding physiological microenvironment, potentially allow for MRI to indicate biological processes. Among the various factors influencing the relaxivity of a CA, the number of inner-sphere water molecules (q) directly coordinated to the metal center, the residence time of the coordinated water molecule (τm), and the rotational correlation time representing the molecular tumbling time of a complex (τR) contribute strongly to the relaxivity of an activatable CA. Tuning the ligand structure and properties has been the subject of intensive research for activatable MR CA designs. This review summarizes a variety of activatable MRI CAs sensitive to common variables in microenvironment in vivo, i.e., pH, luminescence, metal ions, redox, and enzymes, etc., with emphasis on the influence of ligand design on parameters q, τm, and τR.

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“…In addition, Eu(III) has drawn attention for its photostable, narrowband fluorescence lines across in the visible. Coherent manipulation of several spin-selective transitions allows optical detection of the nuclear spin state enabling their implementation as local NMR probes [9][10][11] .…”

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confidence: 99%

Synthesis of luminescent europium defects in diamond

Magyar

Shanley

et al. 2014

Nat Commun

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Lanthanides are vital components in lighting, imaging technologies and future quantum memory applications owing to their narrow optical transitions and long spin coherence times. Recently, diamond has become a pre-eminent platform for the realisation of many experiments in quantum information science. Here we demonstrate a promising approach to incorporate Eu ions into diamond, providing a means to harness the exceptional characteristics of both lanthanides and diamond in a single material. Polyelectrolytes are used to electrostatically assemble Eu(III) chelate molecules on diamond and subsequently chemical vapour deposition is employed for the diamond growth. Fluorescence measurements show that the Eu atoms retain the characteristic optical signature of Eu(III) upon incorporation into the diamond lattice. Computational modelling supports the experimental findings, corroborating that Eu(III) in diamond is a stable configuration. The formed defects demonstrate the outstanding chemical control over the incorporation of impurities into diamond enabled by the electrostatic assembly together with chemical vapour deposition growth.

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Development of Responsive Lanthanide-Based Magnetic Resonance Imaging and Luminescent Probes for Biological Applications

Cited by 39 publications

References 94 publications

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions

Activatable T 1 and T 2 Magnetic Resonance Imaging Contrast Agents

Synthesis of luminescent europium defects in diamond

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