Development of Reichert's membrane in the early mouse embryo

Salamat, Mehrdad; Miosge, Nicolai; Herken, Rainer

doi:10.1007/bf00184752

Cited by 39 publications

(35 citation statements)

References 26 publications

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“…On the other hand, basement membranes are seen at sites in the early embryo at which no mesoderm or mesenchyme is to be found (Salamat et al 1995). Furthermore, nidogen-1 has already been detected in the preimplantation embryo (Wu et al 1988), where there is no mesoderm present at all that could have produced it.…”

Section: Discussionmentioning

confidence: 99%

Nidogen-1: Expression and Ultrastructural Localization During the Onset of Mesoderm Formation in the Early Mouse Embryo

Miosge

Quondamatteo

Klenczar

et al. 2000

J Histochem Cytochem.

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SUMMARY Nidogen-1, a key component of basement membranes, is considered to function as a link between laminin and collagen Type IV networks and is expressed by mesenchymal cells during embryonic and fetal development. It is not clear which cells produce nidogen-1 in early developmental stages when no mesenchyme is present. We therefore localized nidogen-1 and its corresponding mRNA at the light and electron microscopic level in Day 7 mouse embryos during the onset of mesoderm formation by in situ hybridization, light microscopic immunostaining, and immunogold histochemistry. Nidogen-1 mRNA was found not only in the cells of the ectoderm-derived mesoderm but also in the cytoplasm of the endoderm and ectoderm, indicating that all three germ layers express it. Nidogen-1 was localized only in fully developed basement membranes of the ectoderm and was not seen in the developing endodermal basement membrane or in membranes disrupted during mesoderm formation. In contrast, laminin-1 and collagen Type IV were present in all basement membrane types at this developmental stage. The results indicate that, in the early embryo, nidogen-1 may be expressed by epithelial and mesenchymal cells, that both cell types contribute to embryonic basement membrane formation, and that nidogen-1 might serve to stabilize basement membranes in vivo.

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Section: Discussionmentioning

confidence: 99%

Nidogen-1: Expression and Ultrastructural Localization During the Onset of Mesoderm Formation in the Early Mouse Embryo

Miosge

Quondamatteo

Klenczar

et al. 2000

J Histochem Cytochem.

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“…The earlier lineage of extraembryonic tissue, the primitive endoderm, arises in the blastocyst stage and differentiates into two cell types, the visceral endoderm and the parietal endoderm. Parietal endoderm cells migrate along the inner surface of the trophectoderm, where they produce a large amount of extracellular matrix that is deposited to form Reichert's membrane, an extraordinarily thick basement membrane-like structure that separates the yolk cavity from the maternal tissues (43,52).…”

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confidence: 99%

Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression

Futaki

Hayashi

Emoto

et al. 2004

Molecular and Cellular Biology

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During early rodent development, the parietal endoderm appears from an inner cell mass and produces large amounts of basement membrane components, such as laminin-1 and collagen IV. To elucidate the regulatory network for gene expression during these procedures, we constructed a series of short interfering RNA expression vectors targeted to various transcription factors, transfected them into F9 embryonal carcinoma cells, and evaluated the effects of the gene silencing on the induction of parietal endoderm differentiation and basement membrane component production by treating F9 cells with all trans-retinoic acid and dibutyryl cyclic AMP. Among the transcription factors tested, silencing of Sox7 or combined silencing of Gata-4 and Gata-6 resulted in suppression of cell shape changes and laminin-1 production, which are the hallmarks of parietal endoderm differentiation. In cells silenced for Sox7, induction of Gata-4 and Gata-6 by retinoic acid and cyclic AMP treatment was inhibited, while induction of Sox7 was not affected in cells silenced for Gata-4 and Gata-6, indicating that Sox7 is an upstream regulatory factor for these Gata factors. Nevertheless, silencing of Sox7 did not totally cancel the action of retinoic acid, since upregulation of coup-tf2, keratin 19, and retinoic acid receptor ␤2 was not abolished in Sox7-silenced F9 cells. Although overexpression of Sox7 alone was insufficient to induce parietal endoderm differentiation, overexpression of Gata-4 or Gata-6 in Sox7-silenced F9 cells restored the differentiation into parietal endoderm. Sox7 is therefore required for the induction of Gata-4 and Gata-6, and the interplay among these transcription factors plays a crucial role in parietal endoderm differentiation.

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“…In a previous investigation we found developing basement membranes in the blastocyst at the interior side of the mural trophoblast (Salamat et al 1995), an area in which Reichert's membrane later develops. It has been shown that the well-developed, multilayered Reichert's membrane possesses extensive RCA I binding sites (Salamat et al 1993), and that these RCA I binding sites derive from glycoconjucates synthesized by trophoblast cells.…”

Section: Figure 13mentioning

confidence: 74%

Ultrastructural Localization of Binding Sites for the Lectins RCA I, WGA, and LTA in the Preimplantation Mouse Embryo

Miosge

Dresp

Herken

1997

J Histochem Cytochem.

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SUMMARYIn biological tissues, specific carbohydrate moieties of the oligosaccharide chains of glycoproteins can be localized by lectin binding. Such carbohydrate moieties are among the factors that mediate cell-cell or cell-matrix interactions during pre-and postimplantation embryonic development. Binding sites for the lectins RCA I, WGA, and LTA were localized in preimplantation mouse embryos at the ultrastructural level with the help of postembedding lectin gold cytochemistry. WGA and RCA I binding sites, but no LTA binding sites, were present in the zona pellucida. WGA and RCA I binding sites were found at cell surfaces of morulae and in cells of the inner cell mass of blastocysts, suggesting that N -acetylglucosamine-, terminal ␤ -galactosyl-, and N -acetylgalactosamine-rich glycoproteins might be involved in cell-cell and cell-matrix interactions. WGA binding sites were found predominantly in electron lucid vesicles of the blastomeres, whereas RCA I was detected in electron dense vesicles of the compacted morula and later in the polar trophoblast cells. This allows early identification of blastomere cells that later differentiate into the polar trophoblast. (J Histochem Cytochem 45:447-453, 1997)

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Development of Reichert's membrane in the early mouse embryo

Cited by 39 publications

References 26 publications

Nidogen-1: Expression and Ultrastructural Localization During the Onset of Mesoderm Formation in the Early Mouse Embryo

Nidogen-1: Expression and Ultrastructural Localization During the Onset of Mesoderm Formation in the Early Mouse Embryo

Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression

Ultrastructural Localization of Binding Sites for the Lectins RCA I, WGA, and LTA in the Preimplantation Mouse Embryo

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