Development of rear‐impeller axial flow blood pump for realization of axial flow blood pump installed at aortic valve position

Okamoto, Eiji; Yano, Tetsuya; Inoue, Yusuke; Shiraishi, Yasuyuki; Yambe, Tomoyuki; Mitamura, Yoshinori

doi:10.1111/aor.13476

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…In 1989, we propounded a concept of the valvo-pump that was an AFBP implanted at the aortic valve position, 12 and we and other groups have tried to develop AFBPs installed at the aortic valve position. 17,18 However, development of a miniature and high-power motor is a barrier to accomplishing this concept of the valvo-pump. In terms of current motor technology, partial left ventricular support is realistic for the concept of the valvo-pump.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Some research groups have also developed AFBPs implanted at the aortic valve position. [14][15][16] We have developed various AFBPs to accomplish the concept of the valvo-pump, and we are now developing a trans-valve LVAD that unites a rear-impeller AFBP 17 and a polymer membrane valve similar to the jelly-fish valve 18 ( Figure 1). The trans-valve LVAD can be stitched to the base of the aorta like an artificial aortic valve replacement.…”

Section: Introductionmentioning

confidence: 99%

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In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

et al. 2020

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In this study, we developed a trans‐valve left ventricular assist device (LVAD) that unites a rear‐impeller axial‐flow blood pump (AFBP) and a polymer membrane valve placed at the aortic valve position. The diameter and length of the rear impeller AFBP was 12 and 63 mm, respectively. The polymer membrane valve was similar to the jelly‐fish valve consisting of a valve leaflet made of silicone rubber (thickness 0.5 mm), valve ring (diameter: 25 mm), and valve spokes. The trans‐valve LVAD was examined in a mock circulation. An implantable pulsatile flow (PF) VAD was connected to an atrial reservoir to simulate the left ventricle (LV), and the Hall valve was worn in the inflow port, and the trans‐valve LVAD was placed in the outflow port as an outflow valve. When the motor rotational speed increased to 26 400 rpm, the mean aortic flow increased from 4.2 to 5.3 L/min, mean aortic pressure increased from 83.4 to 100 mm Hg, and mean motor current of the implantable PF VAD decreased from 1.18 to 0.94 A (unloading effect on LV −21%). The energy equivalent pressure increased from 85.2 to 102 mm Hg, and surplus hemodynamic energy (SHE) decreased by −15.4% from the baseline. In conclusion, the trans‐valve LVAD has an advantage of preserving pulsatility without any complicated mechanism and is a novel and promising LV support device.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

et al. 2020

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“…Eiji Okamoto et al of Tokai University, Sapporo, Japan investigated rear‐impeller axial flow blood pumps (RIAFBP) to realize a trans‐valve axial VAD which consists of the latter blood pump and a polymer monomembrane aortic valve, such as the jellyfish valve. The motor of the RIAFBP is installed in the left ventricle, and its impeller is placed at the aortic valve position.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2019: A year in review

Malchesky¹

2020

Artificial Organs

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In this Editor’s Review, articles published in 2019 are organized by category and summarized. These provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed Special Issues this year included contributions from the 14th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr Akif Undar, and the 26th Congress of the International Society for Mechanical Circulatory Support edited by Dr Minoru Ono and Dr Francesco Moscato. Additionally, important editorials highlighted the need for sustainability in hemodialysis, challenges and opportunities in mechanical circulatory support, progress in artificial pancreas development, historical perspectives on ventilators and dialysis, tissue engineering for cardiac support, and regional updates from India and China. Our Pioneer Series continues to highlight the many researchers who created this field of study. This year we debuted a new series entitled “Recent Progress in Artificial Organs” prepared by Vakhtang Tchantchaleishvili and Elizabeth Maynes of Thomas Jefferson University, Philadelphia, PA, USA. This series highlights recent advances and new developments in the field. We take this time also to express our gratitude to our authors for contributing their work to this journal. We offer our very special thanks to our reviewers who give so generously of their time and expertise to review, critique, and especially provide meaningful suggestions to the author’s work. Without our dedicated expert reviewers, the quality expected from such a journal would not be possible. We also express our special thanks to our Publisher, John Wiley & Sons, for their expert attention and support in the production Artificial Organs. We look forward to reporting further advances in the coming years.

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“…As a typical pulsating pump, the roller pump offers several significant advantages, including trustworthy flow rates, simple operation, and noncontact pumping, 1 which eliminates blood contamination from mechanical wear. Although the rotary pump (such as the centrifugal pump) obtained more attention from academic circles 8‐12 and it was even believed that the rotary pump would gradually render the roller pump obsolete, increasing studies showed that the centrifugal pump did not have a clear superiority over the roller pump, especially in the short term assist 2‐3,13 . Furthermore, studies have indicated that the pulsatile blood flow can bring about healthier effects such as optimization of microvascular perfusion, 14‐15 higher postperfusion cardiac output, 16 and higher rate of organ recovery 7 .…”

Section: Introductionmentioning

confidence: 99%

Research of flow dynamics and occlusion condition in roller pump systems used for ventricular assist

et al. 2020

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Roller pumps have been widely used in the ventricular assist field for many years, while the significant hemolysis caused by its mechanical stress is still a fundamental problem. Although the usual under‐occlusion setting was considered as an effective method to reduce the hemolysis rate, its nonocclusive condition of the whole process may cause serious backflow results, which exactly places many restrictions on this method. In this study, the simulation experiments based on computational fluid dynamics (CFD) is conducted, and the occlusion angle is proposed and used to explore a more reliable adjustment form of the occlusion condition. The parameterized geometry of a roller pump is established based on the occlusion angle and other parameters. In order to simulate the motion of the roller, the dynamic mesh mode is introduced to the CFD model, and the analytic formulations used to determine the boundary position are derived. In the whole operation process of the roller pump, four feature positions of the rollers were focused and extracted, and the flow characteristics and the shear stress distribution at these positions were demonstrated. It was found that the entry and exit of the rollers could cause clear shear stress peak, especially when one roller entered, the peak got extremely high. Furthermore, the roller pumps with different occlusion angles were compared, and the results showed that decreasing the occlusion angle could lead to a notable decrease in the amplitude and range of high shear stress and the hemolysis index with a small loss of the occlusion duration. It can be concluded that appropriately decreasing the occlusion angle may be an effective method to alleviate the hemolysis which should be given more attention.

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Development of rear‐impeller axial flow blood pump for realization of axial flow blood pump installed at aortic valve position

Cited by 3 publications

References 19 publications

In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

In vitro performance of trans‐valve left ventricular assist device installed at aortic valve position

Artificial Organs 2019: A year in review

Research of flow dynamics and occlusion condition in roller pump systems used for ventricular assist

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